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Protectin D1-d5 Sale

(Synonyms: Neuroprotectin D1-d5, NPD1-d5, PD1-d5) 目录号 : GC48993

An internal standard for the quantification of protectin D1

Protectin D1-d5 Chemical Structure

规格 价格 库存
10 µg
¥2,381.00
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25 µg
¥5,362.00
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Sample solution is provided at 25 µL, 10mM.

产品文档

Quality Control & SDS

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产品描述

Protectin D1-d5 is intended for use as an internal standard for the quantification of protectin D1 by GC- or LC-MS. Protectin D1 is a specialized pro-resolving mediator (SPM) synthesized from docosahexaenoic acid .1 DHA is oxidized to 16S,17S-epoxy protectin, which is converted to protectin D1 enzymatically. Protectin D1 increases phagocytosis of apoptotic polymorphonuclear leukocytes (PMNs) by macrophages in a non-phlogistic manner and is generated in vitro during macrophage-apoptotic interactions.2 It enhances phagocytosis in mice after 24 hours, but not at the initiation or peak of inflammation. It also decreases PMN infiltration in a zymosan-induced mouse model of inflammation when administered at a dose of 300 ng per animal. Protectin D1 (200 µg, i.v.) inhibits increases in neutrophil counts in bronchoalveolar fluid (BALF) and lung myeloperoxidase activity in a mouse model of pulmonary injury and inflammation induced by intratracheal LPS instillation.3 It also decreases pulmonary edema and promotes neutrophil apoptosis in BALF.

1.Rodriguez, A.R., and Spur, B.W.Total synthesis of pro-resolving and tissue-regenerative protectin sulfido-conjugatesTetrahedron Lett.56(42)5811-5815(2015) 2.Schwab, J.M., Chiang, N., Arita, M., et al.Resolvin E1 and protectin D1 activate inflammation-resolution programmesNature447(7146)869-874(2007) 3.Li, X., Li, C., Liang, W., et al.Protectin D1 promotes resolution of inflammation in a murine model of lipopolysaccharide-induced acute lung injury via enhancing neutrophil apoptosisChin. Med. J. (Engl.)127(5)810-814(2014)

Chemical Properties

Cas No. N/A SDF
别名 Neuroprotectin D1-d5, NPD1-d5, PD1-d5
Canonical SMILES O[C@@H](C/C=C\C([2H])([2H])C([2H])([2H])[2H])/C=C\C=C\C=C\[C@H](O)C/C=C\C/C=C\CCC(O)=O
分子式 C22H27D5O4 分子量 365.5
溶解度 Ethanol: 1 mg/ml 储存条件 -80°C
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储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
为了提高溶解度,请将管子加热至37℃,然后在超声波浴中震荡一段时间。
Shipping Condition 评估样品解决方案:配备蓝冰进行发货。所有其他可用尺寸:配备RT,或根据请求配备蓝冰。

溶解性数据

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1 mg 5 mg 10 mg
1 mM 2.736 mL 13.6799 mL 27.3598 mL
5 mM 0.5472 mL 2.736 mL 5.472 mL
10 mM 0.2736 mL 1.368 mL 2.736 mL
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