Proxymetacaine (hydrochloride)
(Synonyms: Proparacaine) 目录号 : GC91488Proxymetacaine is an anesthetic.
Cas No.: 5875-06-9
Sample solution is provided at 25 µL, 10mM.
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Quality Control & SDS
- View current batch:
- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Proxymetacaine is an anesthetic.[1] Intrathecal administration of proxymetacaine reduces motor function, decreases righting behaviors in the placement test, and increases latency to paw withdrawal in the hot plate test in rats (ED50s = 0.24, 0.3, and 0.16 µM/kg, respectively). Topical application of proxymetacaine (0.5% w/v) reduces corneal sensitivity in the corneal touch test in dogs.[2] Formulations containing proxymetacaine have been used to induce anesthesia prior to ocular surgery.
References:
[1].Hung, C.-H., Wang, J.-J., Chen, Y.-C., et al.Intrathecal oxybuprocaine and proxymetacaine produced potent and long-lasting spinal anesthesia in ratsNeurosci. Lett.454(3)(2009).
[2].Herring, I.P., Bobofchak, M.A., Landry, M.P., et al.Duration of effect and effect of multiple doses of topical ophthalmic 0.5% proparacaine hydrochloride in clinically normal dogsAm. J. Vet. Res.66(1)77-80(2005).
| 制备储备液 | |||
 |
1 mg | 5 mg | 10 mg |
| 1 mM | 3.0221 mL | 15.1103 mL | 30.2206 mL |
| 5 mM | 0.6044 mL | 3.0221 mL | 6.0441 mL |
| 10 mM | 0.3022 mL | 1.511 mL | 3.0221 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。