Prunin

Prunin is a polyketide synthase-derived flavonoid glycoside that has been found in G. glabra and has diverse biological activities.^1,2,3,4,5 It inhibits neuraminidase (NA) activity in oseltamivir-sensitive and -resistant H1N1 influenza strains (IC₅₀s = 3 and 4.53 ?M, respectively).² Prunin (2 ?M) scavenges DPPH radicals in a cell-free assay.³ It inhibits the activity of protein tyrosine phosphatase 1B (PTP1B; IC₅₀ = 5.5 ?M for the human enzyme) and increases insulin-induced glucose uptake in insulin-resistant HepG2 hepatocellular carcinoma cells in a concentration-dependent manner.⁴ Prunin inhibits the proliferation of, and induces apoptosis in, HL-60 leukemia cells.⁵

1.Sharma, P., Kumar, V., and Guleria, P.Naringin: Biosynthesis and pharmaceutical applicationsIndian J. Pharm. Sci.81(6)988-999(2019) 2.Grienke, U., Braun, H., Seidel, N., et al.Computer-guided approach to access the anti-influenza activity of licorice constituentsJ. Nat. Prod.77(3)563-570(2014) 3.Sang, S., Lapsley, K., Jeong, W.-S., et al.Antioxidative phenolic compounds isolated from almond skins (Prunus amygdalus Batsch)J. Agric. Food Chem.50(8)2459-2463(2002) 4.Jung, H.A., Ali, M.Y., Bhakta, K., et al.Prunin is a highly potent flavonoid from Prunus davidiana stems that inhibits protein tyrosine phosphatase 1B and stimulates glucose uptake in insulin-resistant HepG2 cellsArch. Pharm. Res.40(1)37-48(2017) 5.Tung, N.H., Son, J.-H., Cho, K., et al.Phenolic components from the leaves of Panax ginseng and their effects on HL-60 human leukemia cellsFood Sci. Biotechnol.19(1)271-274(2010)