Pseudo-UTP,100mM Tris Solution
(Synonyms: Pseudouridine-5'-Triphosphate, 5-Ribosyl Uracil) 目录号 : GB20003
Pseudo-UTP是一种通过碱基异构化反应衍生而来的修饰UTP,常用于药物合成mRNA。
Sample solution is provided at 25 µL, 10mM.
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Quality Control & SDS
- View current batch:
- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Pseudo-UTP is derived from UTP through base isomerization reaction, which can perform complementary base pairing with adenosine like uridine, and change the structure of RNA by improving base pairing, base stacking and main chain stability [1]. The mRNA in which Pseudo-UTP completely replaces UTP exhibits lower immunogenicity, higher stability and translation ability [2].
References:
[1]. Yi-Tao Yu. RNA-guided isomerization of uridine to pseudouridine-pseudouridylation. Clin Chim Acta. 2014;11(12):1483-94. doi: 10.4161/15476286.2014.972855. PMCID: PMC4615163.
[2]. Muthian Shanmugasundaram, et al. An Efficient Protection-Free One-Pot Chemical Synthesis of Modified Nucleoside-5'-Triphosphates. Nucleosides Nucleotides Nucleic Acids. 2016 Jul 2;35(7):356-62.
Pseudo-UTP是由UTP通过碱基异构化反应衍生而来,可以像UTP一样与腺苷酸进行碱基互补配对,通过改善碱基配对、碱基堆叠和主链稳定性来改变RNA结构[1]。Pseudo-UTP完全替代UTP的mRNA表现出更低的免疫原性,更高的稳定性以及翻译能力[2]。
| Cas No. | SDF | ||
| 别名 | Pseudouridine-5'-Triphosphate, 5-Ribosyl Uracil | ||
| 化学名 | (5-(2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl tetrahydrogen triphosphate | ||
| Canonical SMILES | O=C(NC1=O)NC=C1C2C(C(C(O2)COP(O)(OP(O)(OP(O)(O)=O)=O)=O)O)O | ||
| 分子式 | C9H15N2O15P3 | 分子量 | 484 |
| 溶解度 | A solution of water | 储存条件 | Store at -20°C |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
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| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 2.0661 mL | 10.3306 mL | 20.6612 mL |
| 5 mM | 0.4132 mL | 2.0661 mL | 4.1322 mL |
| 10 mM | 0.2066 mL | 1.0331 mL | 2.0661 mL |