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Pseudomonic Acid (lithium salt) Sale

(Synonyms: 假单胞菌酸锂) 目录号 : GC49053

An antibiotic

Pseudomonic Acid (lithium salt) Chemical Structure

Cas No.:73346-79-9

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50mg
¥220.00
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100mg
¥380.00
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Sample solution is provided at 25 µL, 10mM.

Description

Pseudomonic acid is an antibiotic and bacterial metabolite that has been found in P. fluorescens.1 It is bacteriostatic against S. aureus (MIC = 0.05 µg/ml) and active against skin wound clinical isolates of methicillin-resistant S. aureus (MRSA; MICs = 1-4 µg/ml).2,3 Pseudomonic acid inhibits MRSA and P. aeruginosa biofilm formation in vitro.4 It inhibits bacterial cell wall isoleucyl-tRNA synthetase, slowing bacterial growth.2,4 Topical administration of pseudomonic acid (2% v/v) reduces the number of wound colony forming units (CFUs) in a mouse model of MRSA skin infection.3

1.Fuller, A.T., Mellows, G., Woolford, M., et al.Psuedomonic acid: An antibiotic produced by Pseudomonas fluorescensNature234(5329)416-417(1971) 2.Hughes, J., and Mellows, G.On the mode of action of pseudomonic acid: Inhibition of protein synthesis in Staphylococcus aureusJ. Antibiot. (Tokyo)31(4)330-335(1978) 3.Mohammad, H., Cushman, M., and Seleem, M.N.Antibacterial evaluation of synthetic thiazole compounds in vitro and in vivo in a methicillin-resistant Staphylococcus aureus (MRSA) skin infection mouse modelPLoS One10(11)e0142321(2015) 4.Khoshnood, S., Heidary, M., Asadi, A., et al.A review on mechanism of action, resistance, synergism, and clinical implications of mupirocin against Staphylococcus aureusBiomed. Pharmacother.1091809-1818(2019)

化学性质

Cas No. 73346-79-9 SDF
别名 假单胞菌酸锂
Canonical SMILES C[C@H](O)[C@H](C)[C@@](O1)([H])[C@@H]1C[C@@H]2[C@H]([C@H]([C@@H](OC2)C/C(C)=C/C(OCCCCCCCCC([O-])=O)=O)O)O.[Li+]
分子式 C26H43O9·Li 分子量 506.6
溶解度 Ethanol: 30 mg/ml,PBS (pH 7.2): 1 mg/ml 储存条件 -20°C
General tips 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。
储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
为了提高溶解度,请将管子加热至37℃,然后在超声波浴中震荡一段时间。
Shipping Condition 评估样品解决方案:配备蓝冰进行发货。所有其他可用尺寸:配备RT,或根据请求配备蓝冰。

溶解性数据

制备储备液
1 mg 5 mg 10 mg
1 mM 1.9739 mL 9.8697 mL 19.7394 mL
5 mM 0.3948 mL 1.9739 mL 3.9479 mL
10 mM 0.1974 mL 0.987 mL 1.9739 mL
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