PtdIns-(3,4,5)-P3 (1,2-dipalmitoyl)-d62 (sodium salt)

PtdIns-(3,4,5)-P₃ (1,2-dipalmitoyl)-d₆₂ (sodium salt) contains 62 deuterium atoms at the 2, 2', 3, 3', 4, 4', 5, 5', 6, 6', 7, 7', 8, 8', 9, 9', 10, 10', 11, 11', 12, 12', 13, 13', 14, 14', 15, 15', 16, 16, and 16 positions of each fatty acyl chain. It is intended for use as an internal standard for the quantification of PtdIns-(3,4,5)-P₃ (1,2-dipalmitoyl) (sodium salt) by GC- or LC-mass spectrometry (MS). The phosphatidylinositol phosphates represent a small percentage of total membrane phospholipids. However, they play a critical role in the generation and transmission of cellular signals.^1,2 PtdIns-(3,4,5)-P₃ can serve as an anchor for the binding of signal transduction proteins bearing pleckstrin homology (PH) domains. Centuarin α and the Akt-family of GTPase activating proteins are examples of PtdIns-(3,4,5)-P₃-binding proteins.^3,4 Protein-binding to PtdIns-(3,4,5)-P₃ is important for cytoskeletal rearrangements and membrane trafficking. PtdIns-(3,4,5)-P₃ is resistant to cleavage by PI-specific phospholipase C (PLC). Thus, it is likely to function in signal transduction as a modulator in its own right, rather than as a source of inositol tetraphosphates. For further reading on inositol phospholipids, see references ⁵ and ⁶.

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