Pyrazine-2-amidoxime
(Synonyms: 吡嗪-2-甲胺肟) 目录号 : GC44783
A synthetic intermediate useful for pharmaceutical synthesis
Cas No.:51285-05-3
Sample solution is provided at 25 µL, 10mM.
;)
,-1-7$$$37316672.jpg');)
;)
;)
$$$36806353.jpg');)
;33(7)%EF%BC%9A546-561$$$37156877.jpg');)
;)
;)
;)
%201124-1138.$$$35908550.jpg');)
%20766-780.$$$37100057.jpg');)
%20418-432.$$$36893736.jpg');)
%EF%BC%9A-240-255.$$$35108512.jpg');)
533-545$$$36543525.jpg');)
%201-13.$$$36600053.jpg');)
;)
Quality Control & SDS
- View current batch:
- Purity: >97.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Pyrazine-2-amidoxime is a synthetic intermediate useful for pharmaceutical synthesis.
| Cas No. | 51285-05-3 | SDF | |
| 别名 | 吡嗪-2-甲胺肟 | ||
| Canonical SMILES | N/C(C1=NC=CN=C1)=N\O | ||
| 分子式 | C5H6N4O | 分子量 | 138.1 |
| 溶解度 | DMF: 30 mg/ml,DMSO: 30 mg/ml,Ethanol: 0.2 mg/ml,PBS (pH 7.2): 0.1 mg/ml | 储存条件 | Store at -20°C |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
||
| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
 |
1 mg | 5 mg | 10 mg |
| 1 mM | 7.2411 mL | 36.2056 mL | 72.4113 mL |
| 5 mM | 1.4482 mL | 7.2411 mL | 14.4823 mL |
| 10 mM | 0.7241 mL | 3.6206 mL | 7.2411 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。
Pyrazine-2-amidoxime Ni(II) complexes: from ferromagnetic cluster to antiferromagnetic layer
Inorg Chem 2011 Feb 7;50(3):1079-83.PMID:21175167DOI:10.1021/ic1022714.
Tetranuclear [Ni(4)(Hpzaox)(2)(pzaox)(2)(py)(4)](ClO(4))(2)·2py (1), [Ni(4)(Hpzaox)(2)(pzaox)(2)(py)(4)](NO(3))(2)·4py (2), and two-dimensional (2D) [Ni(4)(Hpzaox)(2)(pzaox)(2)(H(2)O)(2)](NO(3))(2)·2H(2)O (3) are prepared via the reaction of NiX(2)·6H(2)O and Pyrazine-2-amidoxime (H(2)pzaox). All compounds contain [Ni(4)(Hpzaox)(2)(pzaox)(2)](2+) fragments, which assemble to form a tetranuclear or polymeric network. Magnetic studies show that the tetranuclear compounds display usual ferromagnetic coupling via the oxime N-O bridges, and the 2D compound displays unusual antiferromagnetic behavior.
High-nuclear heterometallic oxime clusters assembled from triangular subunits: solvothermal syntheses, crystal structures and magnetic properties
Dalton Trans 2017 Dec 19;47(1):169-179.PMID:29192927DOI:10.1039/c7dt03692b.
Three series of six Pyrazine-2-amidoxime (H2pzaox)-based 3d-4f clusters, {Ln8Ni6}, {Ln5Ni10} and {Ln5Ni8} (Ln = Dy and Gd), were solvothermally synthesized in the absence or presence of different coligands, and were structurally and magnetically characterized. The unusual ring-shaped {Ln8(μ3-OH)4} core in the two {Ln8Ni6} complexes is generated by four corner-sharing triangle {Ln3(μ3-OH)} units, which are further connected to six outer NiII ions by twelve deprotonated H2pzaox ligands in three common binding modes. By contrast, the remaining four clusters contain only two corner-sharing {Ln3(μ3-OH)} triangles, which interact with peripheral NiII ions through fourteen H2pzaox ligands in five (for {Ln5Ni10}) and four (for {Ln5Ni8}) different bridging ways. Thus, the interesting core motifs observed in these clusters depend significantly on the number of the triangular {Ln3(μ3-OH)} subunits and their connectivity manner with the singly and doubly deprotonated Pyrazine-2-amidoxime ligand. Additionally, weak ferromagnetic superexchange in the {Dy5Ni10} and {Ln5Ni8} clusters and antiferromagnetic coupling in {Ln8Ni6} and {Gd5Ni10} clusters was respectively mediated by versatile oximate bridges between the intramolecular LnIII and NiII ions. Furthermore, the three DyIII-derived aggregates exhibit slightly temperature-dependent magnetic relaxations under a zero dc field, and the three GdIII-based clusters display large magnetic entropy changes of 23.5 J kg-1 K-1 for {Gd8Ni6}, 19.4 J kg-1 K-1 for {Gd5Ni10}, and 22.4 J kg-1 K-1 for {Ln5Ni8} at 4.0 K and 70 kOe. These interesting results are helpful for the understanding of oximate-based 3d-4f coordination chemistry and their structure-function relationships.