Pyridaben
(Synonyms: 哒螨灵) 目录号 : GC48015
A METI acaricide
Cas No.:96489-71-3
Sample solution is provided at 25 µL, 10mM.
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Quality Control & SDS
- View current batch:
- Purity: >99.50%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Pyridaben is a METI acaricide that inhibits mitochondrial electron transport at complex I (METI; Ki = 0.36 nmol/mg protein in rat brain mitochondria).1 It is active against a variety of mites, inducing 100% mortality of C. malaccensis, D. farina, and T. putrescentia when administered via filter paper contact at doses of 25, 100, and 200 mg/m3, respectively.2 Pyridaben is toxic to rats when administered orally (LD50s = 570 and 1,100 for female and male rats, respectively) and via inhalation (LD50s = 0.62 and 0.66 mg/L for female and male rats, respectively).3 Formulations containing pyridaben have been used in the control of mites in agriculture.
1.Navarro, A., BÁndez, M.J., GÓmez, C., et al.Effects of rotenone and pyridaben on complex I electron transfer and on mitochondrial nitric oxide synthase functional activityJ. Bioenerg. Biomembr.42(5)405-412(2010) 2.Takahashi, M., Shono, T., and Umehara, T.Efficacy of pyridaben against three kinds of mites, Cheyletus malaccensis, Dermatophagoides farinae and Tyrophagus putrescentiaeJpn. J. Sanit. Zool.41(3)257-260(1990) 3.Igarashi, H., and Sakamoto, S.Summary of toxicity studies with pyridabenJ. Pest. Scien.19(4)S243-S251(1994)
| Cas No. | 96489-71-3 | SDF | |
| 别名 | 哒螨灵 | ||
| Canonical SMILES | CC(C)(C)C1=CC=C(CSC2=C(Cl)C(N(C(C)(C)C)N=C2)=O)C=C1 | ||
| 分子式 | C19H25ClN2OS | 分子量 | 364.9 |
| 溶解度 | Chloroform: Slightly Soluble | 储存条件 | 4°C, protect from light |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
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| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 2.7405 mL | 13.7024 mL | 27.4048 mL |
| 5 mM | 0.5481 mL | 2.7405 mL | 5.481 mL |
| 10 mM | 0.274 mL | 1.3702 mL | 2.7405 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。
An overview on the green synthesis and removal methods of Pyridaben
Front Chem 2022 Jul 14;10:975491.PMID:35910743DOI:10.3389/fchem.2022.975491.
Pyridaben is an acaricide widely used around the world to control phytophagous mites, white flies, aphids, and thrips. It is highly toxic to nontarget organisms such as predatory mites, bees, and fishes. Therefore, the occurrence and removal of Pyridaben in food and the environment are worthy of concern. This mini-review focuses on Pyridaben residue levels in crops, aquatic systems, and soils, as well as the green synthesis and removal of Pyridaben. During the period of 2010-2022, Pyridaben was reported in monitoring studies on fruits, vegetables, herbs, bee products, aquatic systems, and soils. Vegetable and agricultural soil samples exhibited the highest detection rates and residue levels. One-pot synthesis offers a green chemistry and sustainable alternative for the synthesis of Pyridaben. Among traditional home treatments, peeling is the most effective way to remove Pyridaben from crops. Magnetic solid-phase extraction technology has emerged as a powerful tool for the adsorption and separation of Pyridaben. Photocatalytic methods using TiO2 as a catalyst were developed as advanced oxidation processes for the degradation of Pyridaben in aqueous solutions. Current gaps in Pyridaben removal were proposed to provide future development directions for minimizing the exposure risk of Pyridaben residues to human and nontarget organisms.
Pyridaben induced cardiotoxicity during the looping stages of zebrafish (Danio rerio) embryos
Aquat Toxicol 2021 Aug;237:105870.PMID:34107429DOI:10.1016/j.aquatox.2021.105870.
Pyridaben is a widely used acaricide in agriculture and reaches a high concentration (97 μg/L) in paddy water for a short time when Pyridaben was applied to rice. However, its toxicity to aquatic organisms is still poorly understood. Therefore, we assessed the Pyridaben cardiotoxicity to aquatic organisms using the zebrafish (Danio rerio) model. We found that Pyridaben is highly toxic to aquatic organisms, and LC50 of Pyridaben for zebrafish at 72 hpf was 100.6 μg/L. Pyridaben caused severe cardiac malformations and functional abnormalities. Morphologic abnormity included severe pericardial edema, cardiomegaly, decreased cardiomyocytes, thinning of the myocardial layer, linear heart, and increased the distance between sinus venous and bulbus arteriosus (SV-BA). Functional failure included arrhythmia, heart failure, and reduced pumping efficiency. The genes involved in heart development, WNT signaling, BMP signaling, ATPase, and cardiac troponin C were abnormally expressed in the Pyridaben treatment group. Exposure to Pyridaben increased oxidative stress and induced cell apoptosis. The above causes may lead to cardiac toxicity. The results suggest that Pyridaben exposure induced elevated oxidative stress through the WNT signaling pathway, which in turn led to apoptosis in the heart and cardiotoxicity. Besides, Pyridaben exposure at the critical stage of cardiac looping (24-36 hpf) resulted in the greatest cardiotoxicity. The chorion reduced the entry of Pyridaben and protected zebrafish embryos, resulting in cardiotoxicity second only to the stage of cardiac looping. The study should provide valuable information that Pyridaben exposure causes cardiotoxicity in zebrafish embryos and have potential health risks for other aquatic organisms and humans.
Setting of an import tolerance for Pyridaben in grapefruits
EFSA J 2022 Sep 26;20(9):e07553.PMID:36188066DOI:10.2903/j.efsa.2022.7553.
In accordance with Article 6 of Regulation (EC) No 396/2005, the applicant Nissan Chemical Europe S.A.S. submitted a request to the competent national authority in the Netherlands to set an import tolerance for the active substance Pyridaben in grapefruits imported from the United States of America. The data submitted in support of the requests were found to be sufficient to derive an MRL proposal of 0.5 mg/kg for grapefruits. Adequate analytical methods for enforcement are available to control the residues of Pyridaben on the commodity under consideration, at or above the validated LOQ of 0.01 mg/kg. Based on the risk assessment results, EFSA concluded that the short-term and long-term intake of residues resulting from the uses of Pyridaben on imported grapefruits from United States according to the reported agricultural practices, is unlikely to present a risk to consumer health.
Pyridaben leads to inhibition of cell growth and induction of cell death through intracellular mechanisms in early pregnancy
Pestic Biochem Physiol 2021 Jan;171:104733.PMID:33357555DOI:10.1016/j.pestbp.2020.104733.
Recently, infertility has become a major global issue. It is crucial to identify environmental factors that lead to infertility. The prevalent use of pesticides in agriculture results in the exposure of livestock and humans to these pesticides. Studies have reported the harmful effects of pesticides on pregnancy. Pyridaben, a pesticide that inhibits mitochondrial complex 1, has been reported to have detrimental effects on neurons, spermatogenesis, hormonal balance, and embryonic development. However, the effect of Pyridaben on the female reproductive system has not yet been studied. Therefore, in this study, we evaluated the effects of Pyridaben on early pregnancy in porcine reproductive cell lines, which are known to mimic the female reproductive system. Results demonstrated that Pyridaben decreased cell growth in porcine endometrial luminal epithelial and porcine trophectoderm cell lines through inhibition of cell signal transduction. Further, Pyridaben increased subG1 phase and late apoptosis through the induction of reactive oxygen species production, mitochondrial dysfunction, calcium unbalances, pro-apoptotic signals, and endoplasmic reticulum (ER) stress. Moreover, we found that Pyridaben induced autophagy and inhibition of placentation through the regulation of ER-mitochondria axis proteins. Overall, Pyridaben was found to be harmful in early pregnancy in pigs and may have similar effects in human pregnancy.
Kinetics of the photolysis of Pyridaben and its main photoproduct in aqueous environments under simulated solar irradiation
RSC Adv 2022 Aug 4;12(33):21647-21654.PMID:35975087DOI:10.1039/d2ra02601e.
The photolytic fate of Pyridaben and its main photolysis product was investigated in different aqueous solutions. Results showed that the photolysis of Pyridaben followed pseudo first-order kinetics or the hockey-stick model. In buffer solutions, the half-life of Pyridaben was the shortest at pH 4, while the degradation rate within 24 h was the highest at pH 9. Humic acids (HA) at concentrations of 1-20 mg L-1 favored the photolysis of Pyridaben while fulvic acids (FA) did not have a significant effect. Nitrate at low concentrations (0.01 mM) accelerated the photolysis and Fe(iii) at high concentrations (0.01 and 0.1 mM) significantly inhibited the photolysis. The photolysis rate of Pyridaben in rainwater, tap water, and river water was significantly higher than that in distilled water. The half-lives in distilled water, rainwater, tap water, river water, and pond water were 2.36, 1.36, 1.61, 1.77, and 2.68 h, respectively. Ultra-high-performance liquid chromatography/high-resolution mass spectrometry identified M328 as a photolysis product. The degradation of M328 followed pseudo first-order kinetics in distilled water, buffer solutions and aqueous solutions fortified with HA. The half-lives of M328 were in the range of 7.07-13.95 h. These results are essential for further environmental risk assessment of Pyridaben.