Pyriproxyfen (S-31183)
(Synonyms: 吡丙醚; S-31183) 目录号 : GC32232
A pyridine insecticide
Cas No.:95737-68-1
Sample solution is provided at 25 µL, 10mM.
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Quality Control & SDS
- View current batch:
- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Pyriproxyfen is a pyridine insecticide that mimics juvenile growth hormone, which prevents larvae from developing into reproduction-capable adults. The LD50 of pyriproxyfen in rats is >5,000 mg/kg, >1,300 mg/cubic meter/4 hours, and >2,000 mg/kg through oral, inhalation, or percutaneous dosing, respectively.1 It is used as a larvicide in the drinking water of 11 municipalities in Brazil and rumors suggested it may be correlated with the increase in cases of microcephaly in Brazil.2 The acceptable daily intake determined by the World Health Organization is 0.3 mg/L.3 The prevalence of microcephaly in Brazil is not higher in municipalities that use pyriproxyfen in the water supply, compared with municipalities that use the larvicide Bti.2 In addition, in zebrafish, even very high doses (0.1 ?g/ml, compared with 0.01 ?g/ml used in practice for pest control) pyriproxyfen does not induce microcephaly or other brain malformations.4 Formulations containing pyriproxyfen are used for flea control in dogs and as an insecticide for ants.5,6
1.Tomlin, C.D.S.The pesticide manual: A world compendium: Incorporating the agrochemicals handbook(1995) 2.de Alburquerque, M.P.M., de Souza, W.V., Mendes, A.d.C.G., et al.Pyriproxyfen and the microcephaly epidemic in Brazil - an ecological approach to explore the hypothesis of their associationMem. Inst. Oswaldo Cruz111(12)774-776(2016) 3.Pyriproxyfen in drinking-water: Background document for development of WHO guidelines for drinking-water qualityWHO/SDE/WSH/07.01/10(2007) 4.Dzieciolowska, S., Larroque, A.-L., Kranjec, E.-A., et al.The larvicide pyriproxyfen blamed during the Zika virus outbreak does not cause microcephaly in zebrafish embryosSci. Rep.740067(2017) 5.Ross, D.H., Arther, R.G., von Simson, C., et al.Evaluation of the efficacy of topically administered imidacloprid?+?pyriproxyfen and orally administered spinosad against cat fleas (Ctenocephalides felis): Impact of treated dogs on flea life stages in a simulated home environmentParasit. Vectors.5192(2012) 6.Vail, K.M., and Williams, D.F.Pharaoh ant (Hymenoptera: Formicidae) colony development after consumption of pyriproxyfen baitsJ. Econ. Entomol.88(6)1695-1702(1995)
| Cas No. | 95737-68-1 | SDF | |
| 别名 | 吡丙醚; S-31183 | ||
| Canonical SMILES | CC(OC1=NC=CC=C1)COC2=CC=C(OC3=CC=CC=C3)C=C2 | ||
| 分子式 | C20H19NO3 | 分子量 | 321.37 |
| 溶解度 | DMSO : ≥ 35 mg/mL (108.91 mM) | 储存条件 | Store at -20°C |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
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| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 3.1117 mL | 15.5584 mL | 31.1168 mL |
| 5 mM | 0.6223 mL | 3.1117 mL | 6.2234 mL |
| 10 mM | 0.3112 mL | 1.5558 mL | 3.1117 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。
Studies on the environmental persistence of S-31183 (Pyriproxyfen): adsorption onto organic matter and potential for leaching through soil
Ecotoxicol Environ Saf 1991 Apr;21(2):207-14.PMID:1676671DOI:10.1016/0147-6513(91)90022-h.
Analytical methods were developed to allow the extraction and analysis of S-31183 (Pyriproxyfen), 2-[1-methyl-2-(4-phenoxyphenoxy)ethoxy]pyridine, in organic matter from animal waste-water lagoons. Analysis of water and organic debris from a treated lagoon showed that the active ingredient readily adsorbed onto organic matter. S-31183 persisted on organic matter for over a 2-month period, during which time the concentration decayed at an exponential rate. In leaching trials with four different soil types, over 50% of the active ingredient applied remained in the upper 6 cm of a 30-cm soil column; there was no indication of a rapid potential for downward migration. The use of S-31183 for treating wastewater lagoons at doses which are effective for mosquito control did not result in any apparent problems of environmental incompatibility.
Efficacy of a juvenile hormone mimic, Pyriproxyfen (S-31183), for mosquito control in dairy wastewater lagoons
J Am Mosq Control Assoc 1990 Mar;6(1):89-92.PMID:2324729doi
Pyriproxyfen (S-31183) was applied to dairy wastewater lagoons, during 1988, at 0.1 kg (AI)/ha in single and multiple applications which resulted in control of Culex spp. larvae for periods of 7 to 68 days. Length of the control period appeared to be related to water quality, with greater residual efficacy in more polluted sources. The AI apparently adsorbed onto organic debris where efficacy remained high in the lagoon even after water was pumped from the lagoon and replenished with untreated wastewater. Alternating treatments with control agents having a different mode of action is suggested to avoid selection of insecticide resistance.
Fate of Pyriproxyfen in Soils and Plants
Toxics 2020 Mar 13;8(1):20.PMID:32183189DOI:10.3390/toxics8010020.
Since the 1990s, the insect growth regulator Pyriproxyfen has been widely used worldwide as a larvicide in vector control and in agriculture to fight a very large number of pests. Due to its widespread use it is of first importance to know how Pyriproxyfen behaves in the terrestrial ecosystems. This was the goal of this work to establish the fate profile of Pyriproxyfen in soils and plants. Thus, in soil, Pyriproxyfen photodegrades slowly but its aerobic degradation is fast. The insecticide presents a high tendency to adsorb onto soils and it is not subject to leaching into groundwater. On the contrary its two main metabolites (4'-OH-Pyr and PYPAC) show a different fate in soil. When sprayed to plants, Pyriproxyfen behaves as a translaminar insecticide. Its half-life in plants ranges from less than one week to about three weeks. The review ends by showing how the fate profile of Pyriproxyfen in soils and plants influences the adverse effects of the molecule on non-target organisms.
Fate and ecotoxicological effects of Pyriproxyfen in aquatic ecosystems
Environ Sci Pollut Res Int 2020 May;27(14):16052-16068.PMID:32180143DOI:10.1007/s11356-020-08345-8.
Pyriproxyfen is an insect growth regulator acting as larvicide against a large spectrum of public health insect pests, especially dipterans. It is also widely used in agriculture and horticulture for the control of many insect species. Disrupting the endocrine system by mimicking the activity of the juvenile hormone, Pyriproxyfen interferes with metamorphosis in insects and prevents them from reaching maturity and reproducing. Because the aquatic ecosystems can be directly or indirectly contaminated by Pyriproxyfen, the goal of this study was to establish the aquatic ecotoxicological profile of Pyriproxyfen and to identify the gaps that need to be filled. Pyriproxyfen is photodegraded quickly in water. In the absence of organic matter, its persistence in aerobic water media is also limited especially with high temperature and sunlight. Analysis of the laboratory and in situ results for more than 60 aquatic algae, plants, invertebrates, and vertebrates shows that the toxicity of Pyriproxyfen is highly variable including within a same taxonomical group. Abiotic and biotic factors can highly influence the toxicity of the molecule. Pyriproxyfen disrupts the development of numerous species and adversely impacts various physiological events. It can also disturb the behavior of the organisms such as their predatory and swimming performances. Although some experimental studies focus on the environmental fate of Pyriproxyfen metabolites, those dealing with their aquatic ecotoxicity assessment are scarce. In the same way, the limited number of studies dealing with the search of Pyriproxyfen residues in lake, river, and other natural aquatic media does not include the identification of the metabolites.
Evaluation of juvenile hormone analogue JHM/S-31183 against immature stages of mosquitoes in natural habitats
Indian J Malariol 1991 Mar;28(1):39-43.PMID:1915983doi
A study was carried out to evaluate the potentiality of Juvenile hormone compound JHM/S-31183 against immatures of mosquitoes in natural habitats. Of two formulations tested 1% emulsifiable formulation was marginally superior than the granule formulation. Adult emergence of An. stephensi was completely inhibited upto 12 weeks when 0.5% granule formulation was applied at 0.04 ppm in wells as against 50% inhibition upto 8 weeks in pools. However, in Culex quinquefasciatus the per cent inhibition of adult emergence varied from 52 to 90 per cent. 100% inhibition in pools upto one week at 0.04 ppm in An. stephensi was also obtained with 1% emulsifiable formulation but the effect was diluted in successive weeks. The impact of this formulation was not much pronounced against Culex quinquefasciatus.