Quercetagetin
(Synonyms: 六羟黄酮/栎草亭,6-Hydroxyquercetin) 目录号 : GC65201
A selective Pim-1 inhibitor
Cas No.:90-18-6
Sample solution is provided at 25 µL, 10mM.
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The proto-oncogene serine/threonine-protein kinases, Pim-1 and Pim-2, are enzymes involved in cytokine signaling and participate in various signal transduction pathways, including cell growth, differentiation, and apoptosis. Their overexpression has been implicated in prostate cancer, some forms of leukemia, and lymphoma. Quercetagetin is a flavonol that inhibits Pim-1 with an IC50 value of 0.34 ?M.1 It is selective for Pim-1, inhibiting Pim-2, PKA, RSK2, and JNK with IC50 values of 3.45, 21.2, 2.82, and 4.6 ?M, respectively.1,2 Quercetagetin has been shown to inhibit Pim-1 activity in intact RWPE2 prostate cancer cells with an ED50 value of 5.5 ?M, which led to significant growth inhibition.1 It can also inhibit the growth of additional prostate epithelial cell lines at a potency proportionate to their respective level of Pim-1 protein.1
1.Holder, S., Zemskova, M., Zhang, C., et al.Characterization of a potent and selective small-molecule inhibitor of the PIM1 kinaseMol. Cancer Ther.6(1)163-172(2007) 2.Baek, S., Kang, N.J., Popowicz, G.M., et al.Structural and functional analysis of the natural JNK1 inhibitor quercetagetinJ. Mol. Biol.425(2)411-423(2013)
PIM1 0.34μM(IC50) | PIM2 3.45μM(IC50) | RSK2 2.82μM(IC50) | PKA 21.2μM(IC50) |
| Cas No. | 90-18-6 | SDF | Download SDF |
| 别名 | 六羟黄酮/栎草亭,6-Hydroxyquercetin | ||
| 分子式 | C15H10O8 | 分子量 | 318.24 |
| 溶解度 | DMSO : 125 mg/mL (392.79 mM; Need ultrasonic) | 储存条件 | Store at -20°C |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
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| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 3.1423 mL | 15.7114 mL | 31.4228 mL |
| 5 mM | 0.6285 mL | 3.1423 mL | 6.2846 mL |
| 10 mM | 0.3142 mL | 1.5711 mL | 3.1423 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。
Quality Control & SDS
- View current batch:
- Purity: >99.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet