Ranitidine hydrochloride
(Synonyms: 盐酸雷尼替丁) 目录号 : GC12365
A histamine H2 receptor antagonist
Cas No.:66357-59-3
Sample solution is provided at 25 µL, 10mM.
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Ranitidine hydrochloride is a histamine H2-receptor antagonist that inhibits stomach acid production. Target: Histamine H2-ReceptorRanitidine hydrochloride is a histamine H2-receptor antagonist with IC50 of 3.3 ± 1.4 uM. It inhibits stomach acid production. It is also used alongside fexofenadine and other antihistamines for the treatment of skin conditions such as hives. It has 10% the affinity that cimetidine has to CYP450 so it causes fewer side effects, but other H2 blockers famotidine and nizatidine have no CYP450 significant interactions [1, 2].
References:
[1]. Herling, A.W., et al., Inhibition of 14C-aminopyrine accumulation in isolated rabbit gastric glands by the H2-receptor antagonist HOE 760 (TZU-0460). Agents Actions, 1987. 20(1-2): p. 35-9.
[2]. Leucuta, A., et al., A pharmacokinetic interaction study between omeprazole and the H2-receptor antagonist ranitidine. Drug Metabol Drug Interact, 2004. 20(4): p. 273-81.
| Cell experiment [1]: | |
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Cell lines |
SVN neurons |
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Preparation method |
The solubility of this compound in DMSO is > 10 mM. General tips for obtaining a higher concentration: Please warm the tube at 37 °C for 10 minutes and/or shake it in the ultrasonic bath for a while. Stock solution can be stored below - 20 °C for several months. |
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Reacting condition |
1 μM |
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Applications |
Ranitidine at 1 μM potently blocked the excitatory responses of SVN neurons to histamine (1 ~ 30 μM). Ranitidine significantly reduced the 23.6%, 35.1% and 48.7% increases in the peak firing rate induced by 1, 3 and 10 μM histamine to 7.1%, 13.7% and 18.3%, respectively. In addition, Ranitidine (1 μM) in combination with Mepyramine (1 μM) almost completely blocked the histamine-induced excitation. |
| Animal experiment [2]: | |
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Animal models |
Wistar rats |
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Dosage form |
25 mg/mL, 2 drops |
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Applications |
In Wistar rats, Ranitidine induced progressive vasoconstriction, with a maximum of 27% decrease in the vascular diameter at 300th s. The administration of histamine after Ranitidine increased the vascular diameter which was relative to the value at 300th s. However, at 600th s, the vascular diameter still could not reach the initial value (at 0th s). |
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Other notes |
Please test the solubility of all compounds indoor, and the actual solubility may slightly differ with the theoretical value. This is caused by an experimental system error and it is normal. |
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References: [1]. Zhuang QX, Wu YH, Wu GY, Zhu JN, Wang JJ. Histamine excites rat superior vestibular nuclear neurons via postsynaptic H1 and H2 receptors in vitro. Neurosignals. 2013;21(3-4):174-83. [2]. Coman OA, Rotar C, Stoleru S, Ghi-Cristescu I, Punescu H, Fulga I. Influencing vascular reactivity in vivo by histaminergic agonists and antagonists. Rom J Morphol Embryol. 2007;48(4):403-6. |
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| Cas No. | 66357-59-3 | SDF | |
| 别名 | 盐酸雷尼替丁 | ||
| 化学名 | (E)-1-N'-[2-[[5-[(dimethylamino)methyl]furan-2-yl]methylsulfanyl]ethyl]-1-N-methyl-2-nitroethene-1,1-diamine;hydrochloride | ||
| Canonical SMILES | CNC(=C[N+](=O)[O-])NCCSCC1=CC=C(O1)CN(C)C.Cl | ||
| 分子式 | C13H22N4O3S.HCl | 分子量 | 350.86 |
| 溶解度 | ≥ 17.543mg/mL in DMSO | 储存条件 | Store at -20°C |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
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| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
 |
1 mg | 5 mg | 10 mg |
| 1 mM | 2.8501 mL | 14.2507 mL | 28.5014 mL |
| 5 mM | 0.57 mL | 2.8501 mL | 5.7003 mL |
| 10 mM | 0.285 mL | 1.4251 mL | 2.8501 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。
Quality Control & SDS
- View current batch:
- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet