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RELM b Mouse

目录号 : GP20901

RELM-Beta Mouse Recombinant

RELM b Mouse Chemical Structure

规格 价格 库存 购买数量
5μg
¥840.00
5-10工作日
25μg
¥2,030.00
5-10工作日
1mg
¥37,800.00
5-10工作日

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Sample solution is provided at 25 µL, 10mM.

产品文档

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产品描述

Mouse RELM-b Recombinant produced in E.Coli is a monomeric, non-glycosylated, polypeptide chain containing 83 amino acids and having a molecular mass of 8.9kDa. The Mouse RETNLB is purified by proprietary chromatographic techniques.

Product Data

Purity Greater than 97% as determined by SDS-PAGE. Source Escherichia Coli.
Phycical Appearance Brownish lyophilized powder. Shipping Condition Shipped at Room temp.
Synonyms Resistin-like beta; RELM beta; Cysteine-rich secreted protein FIZZ2; Colon and small intestine-specific cysteine-rich protein; Cysteine-rich secreted protein A12-alpha-like 1; Colon carcinoma-related gene protein; RELM-b; XCP2; HXCP2.
Amino Acid Sequence MQCSFESLVD QRIKEALSRQ EPKTISCTSV TSSGRLASCP AGMVVTGCAC GYGCGSWDIR NGNTCHCQCS VMDWASARCC RMA.
Solubility Reconstitute at 0.1 mg/ml with sterile pyrogen free water.
Stability Lyophilized RETNLB is stable at -20°C . After reconstitution the protein should be kept at all times at -20°C . It is recommended to add a carrier protein (0.1% HSA or BSA) for long term storage.
Formulation The protein was lyophilized from a concentrated (1mg/ml) protein solution containing 10mM Acetic Acid with 2:1 mannitol to protein.

Introduction

RELM-beta (Resistin-Like Molecule-beta) is a member of a recently identified family of secreted proteins containing a conserved cystein-rich C-terminus. The RELM family consists of resistin (also called FIZZ3), RELM-alfa (FIZZ1), RELM-beta (FIZZ2) and RELM-gamma. Only resisistin and RELM-beta were found in humans whereas all four RELM family members were identified in rodents.RELM-beta appears to be produced as a homodimer exclusively by intestinal goblet cells and can be found in high quantities in stool. Remarkably, stool of germ-free mice displaying sterile intestinal tract does not contain RELM-beta until bacterial colonization takes place after pathogen-free mice entered natural environment. Some, but not all, colon carcinoma cell lines secrete RELM-beta into the cell culture supernatant.The physiological function of RELM-beta is not known. High doses of recombinant RELM-beta showed hyperglycemic effects including lowered glucose disposal and increased hepatic glucose production in mice.

Stability

Lyophilized RETNLB is stable at -20°C . After reconstitution the protein should be kept at all times at -20°C . It is recommended to add a carrier protein (0.1% HSA or BSA) for long term storage.