Decursinol

Decursinol is a coumarin that has been found in Angelica gigas and has diverse biological activities.^1,2,3,4 It inhibits glutamate-induced neuronal cell death in primary rat mixed cortical cells when used at concentrations of 0.1, 1, and 10 ?M. Dietary administration of decursinol (0.004%) reduces decreases in spontaneous alternation induced by amyloid-β (1-42) in the Y-maze, indicating prevention of memory deficits, in mice.² Decursinol (10 mg/kg) reduces tumor metastasis in a CT26 colorectal cancer mouse xenograft model.³ It inhibits acetic acid-induced writhing in mice when administered at a dose of 50 mg/kg.⁴

1.Kang, S.Y., and Kim, Y.C.Decursinol and decursin protect primary cultured rat cortical cells from glutamate-induced neurotoxicityJ. Pharm. Pharmacol.59(6)863-870(2007) 2.Yan, J.-J., Kim, D.-H., Moon, Y.-S., et al.Protection against β-amyloid peptide-induced memory impairment with long-term administration of extract of Angelica gigas or decursinol in miceProg. Neuropsychopharmacol. Biol. Psychiatry28(1)25-30(2004) 3.Son, S.H., Park, K.-K., Park, S.K., et al.Decursin and decursinol from Angelica gigas inhibit the lung metastasis of murine colon carcinomaPhytother. Res.25(7)959-964(2011) 4.Seo, Y.-J., Kwon, M.-S., Park, S.-H., et al.The analgesic effect of decursinolArch. Pharm. Res.32(6)937-943(2009)