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Ipramidil (C80-1324) Sale

(Synonyms: 异丙地尔; C80-1324) 目录号 : GC32496

Ipramidil (C80-1324) (C80-1324) 是一种呋喃化合物。

Ipramidil (C80-1324) Chemical Structure

Cas No.:83656-38-6

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1mg
¥3,570.00
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5mg
¥7,140.00
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10mg
¥12,138.00
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20mg
¥21,420.00
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Sample solution is provided at 25 µL, 10mM.

Description

Ipramidil (C80-1324) is a furoxan compound. Ipramidil (C80-1324) reveals marked dilator activity in the coronary circulation of isolated working hearts.

The vasodilator action of Ipramidil (C80-1324) on coronary vessels is more potent than that of GTN and appears to be biphasic. The increase in coronary flow caused by furoxans as well as by glyceryl trinitrate (GTN) is blunted upon coinfusion of the guanylate cyclase inhibitor methylene blue. NO sign of tachyphylaxis of the vasodilator response is seen upon the repeated or continuous (60 min) application of Ipramidil at a concentration of 1 μg/mL,which induces an increase in coronary flow of 67±9% (N=5). Moreover, the vasodilatoreffect of Ipramidil is not different from control when Ipramidil is given after a 60 min preinfusion of 10 μg/mL GTN, i.e. under conditions of nitrate tolerance (P=0.493, N=3). However,when GTN is applied after a 30 min infusion of Ipramidil, its dilator response is significantly diminished (P=0.006, N=3). Unlike GTN, Ipramidil concentration independently increases the spontaneous beating rate of the hearts by 10-30 beats per minute and appeared to have a weak positive inotropic effect[1].

[1]. Feelisch M, et al. Thiol-mediated generation of nitric oxide accounts for the vasodilator action of furoxans. Biochem Pharmacol. 1992 Sep 25;44(6):1149-57.

化学性质

Cas No. 83656-38-6 SDF
别名 异丙地尔; C80-1324
Canonical SMILES O=C(C1=[N+]([O-])ON=C1C(NC(C)C)=O)NC(C)C
分子式 C10H16N4O4 分子量 256.26
溶解度 Soluble in DMSO 储存条件 Store at -20°C
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储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
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溶解性数据

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1 mg 5 mg 10 mg
1 mM 3.9023 mL 19.5114 mL 39.0229 mL
5 mM 0.7805 mL 3.9023 mL 7.8046 mL
10 mM 0.3902 mL 1.9511 mL 3.9023 mL
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