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Maslinic Acid Sale

(Synonyms: 山楂酸; Crategolic acid; 2α-Hydroxyoleanolic acid) 目录号 : GC17632

Maslinic Acid是一种五环三萜酸,广泛存在于橄榄和其他植物中。Maslinic Acid具有抗炎、抗氧化、抗肿瘤、降血糖和神经保护等多种生物活性。

Maslinic Acid Chemical Structure

Cas No.:4373-41-5

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5mg
¥449.00
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10mg
¥720.00
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25mg
¥1,628.00
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Sample solution is provided at 25 µL, 10mM.

Description

Maslinic acid is a pentacyclic triterpene acid widely found in olives and other plants. Maslinic acid has multiple biological activities such as anti-inflammatory, antioxidant, anti-tumor, hypoglycemic, and neuroprotective[1].

Maslinic Acid (1-10μM; 24h) was proved to induce cell autophagy by disrupting the combination of Bcl2 and Beclin1 in rat PC12 cells[2]. Maslinic acid (6.25, 12.5, 25, 50mM; 48h) significantly decreased lipid accumulation in oleic acid-incubated HepG2 cells[3]. Maslinic acid (0, 25, 30, 35, 40, 45μM; 48h) decreased total cell viability and induced DNA condensation, damage, and fragmentation in HeLa cells[4].

Maslinic Acid (5, 10, 20mg/kg; ip; 8 weeks) treatment for 8 weeks repressed the oxidative stress and inflammation in the kidney of diabetic mice[5]. Maslinic acid (0.3, 1, 3mg/kg; po; administered 3, 6, 9, 12h before kill) enhanced the ERK–CREB and PI3K–Akt signalling pathways in the hippocampus[6].

References:
[1]He Y, Wang Y, Yang K, et al. Maslinic acid: a new compound for the treatment of multiple organ diseases[J]. Molecules, 2022, 27(24): 8732.
[2]Germano A, Saba L, De Francia S, et al. CYP11B1 has no role in mitotane action and metabolism in adrenocortical carcinoma cells[J]. PloS one, 2018, 13(5): e0196931.
[3]Liou C J, Dai Y W, Wang C L, et al. Maslinic acid protects against obesity-induced nonalcoholic fatty liver disease in mice through regulation of the Sirt1/AMPK signaling pathway[J]. The FASEB Journal, 2019, 33(11): 11791.
[4]Lu K W, Yang M D, Peng S F, et al. Maslinic acid induces DNA damage and impairs DNA repair in human cervical cancer HeLa cells[J]. Anticancer Research, 2020, 40(12): 6869-6877.
[5]Gao H, Wu H. Maslinic acid activates renal AMPK/SIRT1 signaling pathway and protects against diabetic nephropathy in mice[J]. BMC Endocrine Disorders, 2022, 22(1): 25.
[6]Bae H J, Kim J, Kim J, et al. The effect of maslinic acid on cognitive dysfunction induced by cholinergic blockade in mice[J]. British Journal of Pharmacology, 2020, 177(14): 3197-3209.

Maslinic Acid是一种五环三萜酸,广泛存在于橄榄和其他植物中。Maslinic Acid具有抗炎、抗氧化、抗肿瘤、降血糖和神经保护等多种生物活性[1]

Maslinic Acid(1-10μM;24h)可通过破坏大鼠PC12细胞中Bcl2和Beclin1的结合诱导细胞自噬[2]。Maslinic Acid(6.25、12.5、25、50mM;48h)可显著减少油酸诱导的HepG2细胞的脂质积累[3]。Maslinic Acid(0、25、30、35、40、45μM;48h)会降低HeLa细胞的总存活率,并诱导DNA凝聚、损伤和破碎[4]

Maslinic Acid(5、10、20mg/kg;ip;8weeks)治疗 8 周可抑制糖尿病小鼠肾脏的氧化应激和炎症[5]。Maslinic Acid(0.3、1、3mg/kg;po;在处死前3、6、9和12h给药)增强了海马中 ERK-CREB 和 PI3K-Akt 信号通路[6]

实验参考方法

Cell experiment [1]:

Cell lines

PC12 cells

Preparation Method

Before drug treatment, cells were subcultured in 6-well plates and the medium was changed to DMEM containing 2% FBS. The day after cell adhesion, different concentrations of Maslinic Acid and positive control rapamycin (Rap) (10μM) were added to different wells and incubated for 24 hours.

Reaction Conditions

1-10μM; 24h

Applications

Maslinic Acid was proved to induce cell autophagy by disrupting the combination of Bcl2 and Beclin1 in rat PC12 cells.
Animal experiment [2]:

Animal models

Diabetic mouse model

Preparation Method

Streptozocin was used to induce diabetic mouse model. Fasting blood glucose levels > 300mg/dL was regarded as the incidence of diabetes. Diabetic mice of similar body weight were randomly divided into four groups: STZ (diabetic control group), MA5 (diabetic mice treated with 5mg/kg Maslinic Acid), MA10 (diabetic mice treated with 10mg/kg Maslinic Acid), and MA20 (diabetic mice treated with 20mg/kg Maslinic Acid). Normal mice were in the normal control group (NC). Maslinic acid was injected intraperitoneally every 3 days after diabetes induction for 8 weeks. The changes in body weight and fasting glucose levels of mice were evaluated, respectively.

Dosage form

5, 10, 20mg/kg; q3d; ip; 8 weeks

Applications

Maslinic Acid treatment for 8 weeks repressed the oxidative stress and inflammation in the kidney of diabetic mice.

References:
[1]. Germano A, Saba L, De Francia S, et al. CYP11B1 has no role in mitotane action and metabolism in adrenocortical carcinoma cells[J]. PloS one, 2018, 13(5): e0196931.
[2]. Gao H, Wu H. Maslinic acid activates renal AMPK/SIRT1 signaling pathway and protects against diabetic nephropathy in mice[J]. BMC Endocrine Disorders, 2022, 22(1): 25.

化学性质

Cas No. 4373-41-5 SDF
别名 山楂酸; Crategolic acid; 2α-Hydroxyoleanolic acid
化学名 2α,3β-dihydroxy-olean-12-en-28-oic acid
Canonical SMILES CC1(C)CC[C@]2(C(O)=O)CC[C@@]3(C)[C@]4(C)CCC5C(C)(C)[C@@H](O)[C@H](O)C[C@]5(C)[C@@]4([H])CC=C3[C@@]2([H])C1
分子式 C30H48O4 分子量 472.7
溶解度 ≤0.5mg/ml in ethanol;20mg/ml in DMSO;15mg/ml in dimethyl formamide 储存条件 Store at -20°C
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1 mM 2.1155 mL 10.5775 mL 21.1551 mL
5 mM 0.4231 mL 2.1155 mL 4.231 mL
10 mM 0.2116 mL 1.0578 mL 2.1155 mL
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