(R)-3-Hydroxybutanoic acid
(Synonyms: (R)-3-羟基丁酸,(R)-(-)-3-Hydroxybutanoic acid; (R)-3-Hydroxybutyric acid) 目录号 : GC30210
(R)-3-Hydroxybutanoic acid是一种聚羟基丁酸酯（PHB）单体，能够通过与各种羟基脂肪酸反应制备共聚物，具有工业和医药用途。
Cas No.:625-72-9
Sample solution is provided at 25 µL, 10mM.
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(R)-3-Hydroxybutanoic acid is a polyhydroxybutyrate (PHB) monomer that can be reacted with various hydroxy fatty acids to prepare copolymers with industrial and pharmaceutical uses[1, 2, 3]. (R)-3-Hydroxybutanoic acid is a metabolite obtained from ethyl acetate catalyzed by 3-hydroxybutyrate dehydrogenase[4]. (R)-3-Hydroxybutanoic acid can be used as a nutritional source and a precursor of vitamins, antibiotics and pheromones[5].
References:
[1] Kok F, Hasirci V. Polyhydroxybutyrate and its copolymers: Applications in the medical field[J]. Tissue Engineering and Novel Delivery Systems. 1th ed. Arcel Dekker: New York, NY, USA, 2004: 543-562.
[2] Md. Iqbal N, Amirul A A. Synthesis of P (3HB‐co‐4HB) copolymer with target‐specific 4HB molar fractions using combinations of carbon substrates[J]. Journal of Chemical Technology & Biotechnology, 2014, 89(3): 407-418.
[3] Kundu P P, Nandy A, Mukherjee A, et al. Polyhydroxyalkanoates: Microbial synthesis and applications[J]. Encyclopedia of Biomedical Polymers and Polymeric Biomaterials; CRC Press: Boca Raton, FL, USA, 2015, 11: 10444.
[4] Yañez L, Conejeros R, Vergara-Fernández A, et al. Beyond intracellular accumulation of polyhydroxyalkanoates: chiral hydroxyalkanoic acids and polymer secretion[J]. Frontiers in Bioengineering and Biotechnology, 2020, 8: 248.
[5] Ren Q, Grubelnik A, Hoerler M, et al. Bacterial poly (hydroxyalkanoates) as a source of chiral hydroxyalkanoic acids[J]. Biomacromolecules, 2005, 6(4): 2290-2298.
(R)-3-Hydroxybutanoic acid是一种聚羟基丁酸酯（PHB）单体，能够通过与各种羟基脂肪酸反应制备共聚物，具有工业和医药用途[1, 2, 3]。(R)-3-Hydroxybutanoic acid是一种代谢物，由 3-羟基丁酸脱氢酶催化乙酸乙酯获得[4]。(R)-3-Hydroxybutanoic acid能够可作为营养来源和维生素、抗生素和信息素的前体[5]。
| Cas No. | 625-72-9 | SDF | |
| 别名 | (R)-3-羟基丁酸,(R)-(-)-3-Hydroxybutanoic acid; (R)-3-Hydroxybutyric acid | ||
| Canonical SMILES | C[C@@H](O)CC(O)=O | ||
| 分子式 | C4H8O3 | 分子量 | 104.1 |
| 溶解度 | Water : ≥ 25 mg/mL (240.15 mM) | 储存条件 | Store at -20°C |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
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| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 9.6061 mL | 48.0307 mL | 96.0615 mL |
| 5 mM | 1.9212 mL | 9.6061 mL | 19.2123 mL |
| 10 mM | 0.9606 mL | 4.8031 mL | 9.6061 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。
Quality Control & SDS
- View current batch:
- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet