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Scoulerine Sale

(Synonyms: 金黄紫堇碱,(-)-Scoulerine; Discretamine) 目录号 : GC39798

A benzylisoquinoline alkaloid with diverse biological activities

Scoulerine Chemical Structure

Cas No.:6451-73-6

规格 价格 库存 购买数量
1mg
¥495.00
现货
5mg
¥1,800.00
现货
10mg
¥3,150.00
现货

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Sample solution is provided at 25 µL, 10mM.

Description

Scoulerine is a benzylisoquinoline alkaloid that has been found in C. cava and has diverse biological activities.1,2,3 It selectively binds to the dopamine D1 and D2 receptors (Kis = 22 and 214 nM, respectively) over the serotonin (5-HT) receptor subtypes 5-HT1A and 5-HT2A in HEK293 cells when used at a concentration of 10 ?M.1 Scoulerine inhibits proliferation in a panel of leukemia cell lines (IC50s = 2.7-6.5 ?M).2 It inhibits methamphetamine-induced conditioned place preference in mice when administered at a dose of 5 mg/kg.3

1.Sun, H., Zhu, L., Yang, H., et al.Asymmetric total synthesis and identification of tetrahydroprotoberberine derivatives as new antipsychotic agents possessing a dopamine D1, D2 and serotonin 5-HT1A multi-action profileBioorg. Med. Chem.21(4)856-868(2013) 2.Habartova, K., Havelek, R., Seifrtova, M., et al.Scoulerine affects microtubule structure, inhibits proliferation, arrests cell cycle and thus culminates in the apoptotic death of cancer cellsSci. Rep.8(1)4829(2018) 3.Mi, G., Gao, Y., Yan, H., et al.l-Scoulerine attenuates behavioural changes induced by methamphetamine in zebrafish and miceBehav. Brain Res.298(Pt A)97-104(2016)

化学性质

Cas No. 6451-73-6 SDF
别名 金黄紫堇碱,(-)-Scoulerine; Discretamine
Canonical SMILES OC1=C(OC)C=C(CCN2CC3=C(O)C(OC)=CC=C3C[C@]24[H])C4=C1
分子式 C19H21NO4 分子量 327.37
溶解度 Soluble in DMSO 储存条件 Store at -20°C
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储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
为了提高溶解度,请将管子加热至37℃,然后在超声波浴中震荡一段时间。
Shipping Condition 评估样品解决方案:配备蓝冰进行发货。所有其他可用尺寸:配备RT,或根据请求配备蓝冰。

溶解性数据

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1 mg 5 mg 10 mg
1 mM 3.0546 mL 15.2732 mL 30.5465 mL
5 mM 0.6109 mL 3.0546 mL 6.1093 mL
10 mM 0.3055 mL 1.5273 mL 3.0546 mL
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