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SRS16-86

目录号 : GC44947

A ferroptosis inhibitor

SRS16-86 Chemical Structure

Cas No.:1793052-96-6

规格 价格 库存 购买数量
1mg
¥302.00
现货
5mg
¥720.00
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10mg
¥1,170.00
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25mg
¥2,025.00
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50mg
¥3,150.00
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100mg
¥4,725.00
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Sample solution is provided at 25 µL, 10mM.

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客户使用产品发表文献 1

Description

SRS16-86 is an inhibitor of ferroptosis.[1] It inhibits ferroptosis induced by erastin in HT-1080 and NIH3T3 cells when used at a concentration of 1 μM. SRS16-86 (2 mg/kg) prevents renal tubular damage and increases in serum levels of urea and creatine in a mouse model of renal ischemia-reperfusion injury (IRI). In a rat model of spinal cord injury, SRS16-86 (15 mg/kg) increases the levels of glutathione peroxidase 4 (GPX4), system xc-cystine-glutamate transporter (xCT), and glutathione (GSH) and decreases levels of IL-1β, TNF-α, ICAM-1, and the lipid peroxidation marker 4-hydroxy nonenal (4HNE) in injured spinal cord epicenters.[2] It also increases tissue sparing and improves locomotor recovery in the same model.

Reference:
1. Linkermann, A., Skouta, R., Himmerkus, N., et al. Synchronized renal tubular cell death involves ferroptosis. Proc. Natl. Acad. Sci. U.S.A. 111(47), 16836-16841 (2014).
2. Zhang, Y., Sun, C., Zhao, C., et al. Ferroptosis inhibitor SRS 16-86 attenuates ferroptosis and promotes functional recovery in contusion spinal cord injury. Brain Res. 1706, 48-57 (2019).

化学性质

Cas No. 1793052-96-6 SDF
化学名 3-[(Z)-(5-pyrimidinylmethylene)amino]-4-(tricyclo[3.3.1.13,7]dec-1-ylamino)-benzoic acid, 1,1-dimethylethyl ester
Canonical SMILES O=C(OC(C)(C)C)C1=CC=C(NC23C[C@H]4C[C@H](C[C@H](C4)C3)C2)C(/N=C\C5=CN=CN=C5)=C1
分子式 C26H32N4O2 分子量 432.6
溶解度 25mg/ml soluble in organic solvent chloroform, slight in ethanol & DMSO 储存条件 4°C, protect from light
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储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
为了提高溶解度,请将管子加热至37℃,然后在超声波浴中震荡一段时间。
Shipping Condition 评估样品解决方案:配备蓝冰进行发货。所有其他可用尺寸:配备RT,或根据请求配备蓝冰。

溶解性数据

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1 mg 5 mg 10 mg
1 mM 2.3116 mL 11.558 mL 23.116 mL
5 mM 0.4623 mL 2.3116 mL 4.6232 mL
10 mM 0.2312 mL 1.1558 mL 2.3116 mL
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