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Thiocolchicoside Sale

(Synonyms: 硫秋水仙苷) 目录号 : GC39126

A GABAA receptor antagonist

Thiocolchicoside Chemical Structure

Cas No.:602-41-5

规格 价格 库存 购买数量
10mM (in 1mL DMSO)
¥260.00
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1mg
¥98.00
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5mg
¥209.00
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10mg
¥346.00
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25mg
¥567.00
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50mg
¥856.00
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100mg
¥1,269.00
现货

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Sample solution is provided at 25 µL, 10mM.

Description

Thiocolchicoside is a GABAA receptor antagonist.1 It inhibits GABAA receptor-mediated currents in Purkinje cells isolated from rat cerebellum (IC50 = 0.15 ?M). It binds strychnine-sensitive glycine receptors in isolated rat spinal cord (IC50 = 1.58 ?M).2 Thiocolchicoside inhibits cell growth in a panel of cancer cell lines, including KBM5 leukemia and U266 myeloma cells, SCC4 squamous cell carcinoma cells, and HCT116 colon, MCF-7 breast, and A293 kidney cancer cells when used at concentrations ranging from 25 to 100 ?M.3 It inhibits the anti-apoptotic proteins Bcl-2, X-linked inhibitor of apoptosis (XIAP), myeloid cell leukemia-1 (Mcl-1), Bcl-xL, cIAP-1, and cIAP-2 in KBM5 cells in a concentration-dependent manner. It also inhibits TNF-α-induced NF-κB activation and IκBα degradation in KBM5 cells in a concentration-dependent manner. Formulations containing thiocolchicoside have been used as muscle relaxers in the treatment of rheumatoid arthritis, joint stiffness, and muscle stiffness.

1.Carta, M., Murru, L., Botta, P., et al.The muscle relaxant thiocolchicoside is an antagonist of GABAA receptor function in the central nervous systemNeuropharmacology51(4)805-815(2006) 2.Cimino, M., Marini, P., and Cattabeni, F.Interaction of thiocolchicoside with [3H]strychnine binding sites in rat x spinal cord and brainstemEur. J. Pharmacol.318(1)201-204(1996) 3.Reuter, S., Prasad, S., Phromnoi, K., et al.Thiocolchicoside exhibits anticancer effects through downregulation of NF-κB pathway and its regulated gene products linked to inflammation and cancerCancer Prev. Res. (Phila)3(11)1462-1472(2010)

化学性质

Cas No. 602-41-5 SDF
别名 硫秋水仙苷
Canonical SMILES CSC1=CC=C2C3=C(OC)C(OC)=C(O[C@@H]4O[C@H](CO)[C@@H](O)[C@H](O)[C@H]4O)C=C3CC[C@H](NC(C)=O)C2=CC1=O
分子式 C27H33NO10S 分子量 563.62
溶解度 DMSO : 100mg/mL; Water : 100mg/mL 储存条件 Store at -20°C
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储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
为了提高溶解度,请将管子加热至37℃,然后在超声波浴中震荡一段时间。
Shipping Condition 评估样品解决方案:配备蓝冰进行发货。所有其他可用尺寸:配备RT,或根据请求配备蓝冰。

溶解性数据

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1 mg 5 mg 10 mg
1 mM 1.7742 mL 8.8712 mL 17.7425 mL
5 mM 0.3548 mL 1.7742 mL 3.5485 mL
10 mM 0.1774 mL 0.8871 mL 1.7742 mL
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