2-Heptanol
(Synonyms: 2-庚醇) 目录号 : GC61901
2-Heptanol 是姜黄和姜黄根茎精油中鉴定出的化学成分之一。根茎精油具有良好的抗菌和抗氧化活性。
Cas No.:543-49-7
Sample solution is provided at 25 µL, 10mM.
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Quality Control & SDS
- View current batch:
- Purity: >99.50%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
2-Heptanol is one of chemical constituents identified in the essential oil of rhizome of Curcuma angustifolia and Curcuma zedoaria. Rhizome essential oil exhibited good antimicrobial and antioxidant activity[1].
References:
[1]. Sudipta Jena, et al. Deeper insight into the volatile profile of essential oil of two Curcuma species and their antioxidant and antimicrobial activities. Industrial Crops and Products. Volume 155, 1 November 2020, 112830.
| Cas No. | 543-49-7 | SDF | |
| 别名 | 2-庚醇 | ||
| Canonical SMILES | CC(O)CCCCC | ||
| 分子式 | C7H16O | 分子量 | 116.2 |
| 溶解度 | DMSO : 100 mg/mL (860.59 mM; Need ultrasonic) | 储存条件 | Store at -20°C |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
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| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 8.6059 mL | 43.0293 mL | 86.0585 mL |
| 5 mM | 1.7212 mL | 8.6059 mL | 17.2117 mL |
| 10 mM | 0.8606 mL | 4.3029 mL | 8.6059 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。
Microbial volatile organic compounds 2-Heptanol and acetoin control Fusarium crown and root rot of tomato
J Cell Physiol 2022 Oct 2.PMID:36183375DOI:10.1002/jcp.30889.
Some microbial volatile organic compounds (mVOCs) can act as antagonistic weapons against plant pathogens, but little information is available on the contribution of individual mVOC to biocontrol and how they interact with plant pathogens. In this study, the Bacillus subtilis strain N-18 isolated from the rhizosphere of healthy plants grown in areas where Fusarium crown and root rot (FCRR) of tomato occurs could reduce the 30% of the incidence of FCRR. Moreover, the volatile organic compounds (VOCs) produced by N-18 had inhibitory effects on Fusarium oxysporum f. sp. radicis-lycopersici (FORL). The identification of VOCs of N-18 was analyzed by the solid-phase microextraction coupled to gas chromatography-mass spectrometry. Meanwhile, we conducted sensitivity tests with these potential active ingredients and found that the volatile substances acetoin and 2-Heptanol can reduce the 41.33% and 35% of the incidence of FCRR in tomato plants. In addition, the potential target protein of acetoin, found in the cheminformatics and bioinformatics database, was F. oxysporum of hypothetical protein AU210_012600 (FUSOX). Molecular docking results further predicted that acetoin interacts with FUSOX protein. These results reveal the VOCs of N-18 and their active ingredients in response to FORL and provide a basis for further research on regulating and controlling FCRR.
Synthesis of enantiomerically enriched 2-Heptanol and 3-octanol by microbial reductases ofCurvularia falcata andMucor species
J Chem Ecol 1987 Feb;13(2):357-61.PMID:24301814DOI:10.1007/BF01025895.
Certain insects produce 2-Heptanol or 3-octanol in various glandular secretions and recent studies have shown that the 3-octanol of two different genera of ants (Crematogaster andMyrmica) can be either the (S)-(+) or mainly the (R)-(-) enantiomer, respectively. Synthesis of each of these alcohols can be achieved in relatively high enantiomeric purity by certain microbial reductases. The corresponding ketone of each alcohol is reduced byCurvularia falcata, giving an alcohol which is about 90% the (S)-(+) enantiomer, and twoMucor species give as much as 80% the (R)-(-) enantiomer. The synthesis of certain chiral alcohols from their corresponding ketones by microbial reductases can offer a simple procedure for obtaining sufficient amounts of these substances for certain behavioral studies.
Preparation of passion fruit-typical 2-alkyl ester enantiomers via lipase-catalyzed kinetic resolution
J Agric Food Chem 2010 May 26;58(10):6328-33.PMID:20415422DOI:10.1021/jf100432s.
The preparation of ester enantiomers (acetates, butanoates, hexanoates and octanoates) of the secondary alcohols 2-pentanol, 2-Heptanol and 2-nonanol via lipase-catalyzed kinetic resolutions was investigated. Conversion rates and stereochemical courses of esterification and hydrolysis reactions catalyzed by commercially available enzyme preparations were followed for the homologous series of these passion fruit-typical 2-alkyl esters by capillary gas chromatography using heptakis(2,3-di-O-methyl-6-O-tert-butyldimethylsilyl)-beta-cyclodextrin as chiral stationary phase. An efficient method was developed to prepare the ester enantiomers via lipase-catalyzed esterifications: optically pure (R)-2-alkyl esters (ee > 99.9%) were obtained by esterification of the racemic alcohols with enantioselective Candida antarctica lipase B (immobilized) as catalyst. The subsequent esterification of the unreacted alcohols using lipase from Candida cylindracea yielded the optically enriched (S)-esters (ee > 81.4%). The separation of the products via liquid solid chromatography using a mixture of silica gel and aluminum oxide (basic) resulted in high chemical purities and yields (> 40 mol %).
Solvent effect on ion-pair extraction of 2-(2-pyridylazo)-1-naphthol-4-sulfonate anion with solvated hydroxonium ion using alcohols and 1-octanol/octane mixed solvents
Anal Sci 2001 Feb;17(2):291-5.PMID:11990543DOI:10.2116/analsci.17.291.
Extraction of 2-(2-pyridylazo)-1-naphthol-4-sulfonate anion with solvated hydroxonium ion was carried out using 14 kinds of alcohols and 1-octanol/octane mixed solvents as a solvent at 25 degrees C. Alcohols are 1-pentanol, 1-hexanol, 1-heptanol, 2-Heptanol, 3-heptanol, 4-heptanol, 1-octanol, 2-octanol, 3-octanol, 1-nonanol, 2-nonanol, 3-nonanol, 5-nonanol and 1-decanol. Among them, 1-octanol was found to be extremely high in extractability for 2-(2-pyridylazo)-1-naphthol-4-sulfonate anion with hydroxonium cation. The extraction equilibrium for the systems using 1-octanol/octane mixed solvents was analyzed in detail in order to examine the extraction mechanism for these extraction systems. 2-(2-Pyridylazo)-1-naphthol-4-sulfonate anion was found to be extracted with the hydroxonium ion solvated by three 1-octanol molecules as an ion-pair. The extraction and partition constants of the ion-pair of 2-(2-pyridylazo)-1-naphthol-4-sulfonate anion with solvated hydroxonium ion were estimated in the 1-octanol/octane mixed solvent systems.
Identification of the n-heptane metabolites in rat and human urine
Arch Toxicol 1986 Apr;58(4):229-34.PMID:3718225DOI:10.1007/BF00297111.
Numerous n-heptane metabolites have been identified and quantified by gas chromatography and mass spectrometry in some tissues and in the urine of Sprague Dawley rats exposed for 6 h to 1800 ppm n-heptane. 2-Heptanol and 3-heptanol were the main biotransformation products of the solvent. 2-Heptanone, 3-heptanone, 4-heptanol, 2,5-heptanedione, gamma-valerolactone, 2-ethyl-5-methyl-2,3-dihydrofuran and 2,6-dimethyl-2,5-dihydropyran were also found as metabolites of n-heptane. In five shoe factory workers and in three rubber factory workers the mean exposure to technical heptane was measured (n-heptane ranged between 5 and 196 mg/m3). In the urine collected at the end of their work shift some n-heptane biotransformation products were found: 2-Heptanol, 3-heptanol, 2-heptanone, 4-heptanone and 2,5-heptanedione. 2-Heptanol was the main n-heptane metabolite and its urinary concentrations ranged between 0.1 and 1.9 mg/l. Urinary 2,5-heptanedione was detectable only in some samples and at very low concentration (0.1-0.4 mg/l). These data suggest that n-heptane can be considered as a neurotoxic product, since it gives rise to 2,5-heptanedione, but the small amount of the urinary metabolite is very unlikely to cause clinical damage to the peripheral nervous system.