Fenitrothion
(Synonyms: 杀螟松) 目录号 : GC60164
Fenitrothion 是应用最广泛的有机磷农药之一，是一种抑制胆碱酯酶的杀虫剂/杀螨剂。Fenitrothion 作为一种广谱杀虫剂，广泛应用于棉田作物、蔬菜作物、水果作物和大田作物，尤其是水稻。Fenitrothion 导致硝基酚的积累。
Cas No.:122-14-5
Sample solution is provided at 25 µL, 10mM.
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Quality Control & SDS
- View current batch:
- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Fenitrothion, one of the most widely used organophosphorus pesticides, is a cholinesterase inhibiting insecticide/acaricid. Fenitrothion is widely used, as a broad-spectrum insecticide, on cotton crops, vegetables crops, fruit crops, and field crops especially paddy. Fenitrothion leads to accumulation of nitrophenols[1][2].
[1]. Abdel-Ghany R, et al. Impact of Exposure to Fenitrothion on Vital Organs in Rats. J Toxicol. 2016;2016:5609734. [2]. Qing Hong, et al. A microcosm study on bioremediation of fenitrothion-contaminated soil using Burkholderia sp. FDS-1. International Biodeterioration & Biodegradation
| Cas No. | 122-14-5 | SDF | |
| 别名 | 杀螟松 | ||
| Canonical SMILES | S=P(OC)(OC)OC1=CC=C([N+]([O-])=O)C(C)=C1 | ||
| 分子式 | C9H12NO5PS | 分子量 | 277.23 |
| 溶解度 | Ethanol : 100 mg/mL (360.71 mM; Need ultrasonic) | 储存条件 | |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
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| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 3.6071 mL | 18.0356 mL | 36.0711 mL |
| 5 mM | 0.7214 mL | 3.6071 mL | 7.2142 mL |
| 10 mM | 0.3607 mL | 1.8036 mL | 3.6071 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。
Acute Fenitrothion poisoning
Can Med Assoc J 1977 Feb 19;116(4):377-9.PMID:844021doi
A technician was accidentally exposed to the organophosphorus insecticide Fenitrothion and subsequently treated with pralidoxime for the autonomic, somatic and psychiatric manifestations of intoxication. Although long-term therapy with pralidoxime is not recommended, this patient required and obtained symptomatic benefit from its prolonged use. Erythrocytic and plasma cholinesterase activities had been monitored prior to exposure and were monitored throughout treatment and following recovery. Continual monitoring of cholinesterase activities of individuals occupationally exposed to organophosphorus ester insecticides and early diagnosis are essential.
Novel DNA Aptameric Sensors to Detect the Toxic Insecticide Fenitrothion
Int J Mol Sci 2021 Oct 7;22(19):10846.PMID:34639187DOI:10.3390/ijms221910846.
Fenitrothion is an insecticide belonging to the organophosphate family of pesticides that is widely used around the world in agriculture and living environments. Today, it is one of the most hazardous chemicals that causes severe environmental pollution. However, detection of Fenitrothion residues in the environment is considered a significant challenge due to the small molecule nature of the insecticide and lack of molecular recognition elements that can detect it with high specificity. We performed in vitro selection experiments using the SELEX process to isolate the DNA aptamers that can bind to Fenitrothion. We found that newly discovered DNA aptamers have a strong ability to distinguish Fenitrothion from other organophosphate insecticides (non-specific targets). Furthermore, we identified a fenitrothion-specific aptamer; FenA2, that can interact with Thioflavin T (ThT) to produce a label-free detection mode with a Kd of 33.57 nM (9.30 ppb) and LOD of 14 nM (3.88 ppb). Additionally, the FenA2 aptamer exhibited very low cross-reactivity with non-specific targets. This is the first report showing an aptamer sensor with a G4-quadruplex-like structure to detect Fenitrothion. Moreover, these aptamers have the potential to be further developed into analytical tools for real-time detection of Fenitrothion from a wide range of samples.
Development of Fenitrothion adsorbing recombinant Escherichia coli by cell surface display of pesticide-binding peptide
J Biotechnol 2020 Oct 10;322:90-95.PMID:32707208DOI:10.1016/j.jbiotec.2020.07.014.
In this study, constructed Escherichia coli could efficiently adsorb Fenitrothion by displaying a pesticide-binding peptide on it using the anchoring motif OmpC. A codon-optimized, pesticide-binding peptide was attached to the C-terminus of OmpC at loop 7 (993 bp). The efficiency of Fenitrothion binding by the monomer peptide was evaluated under different temperatures, pH levels, and Fenitrothion concentrations. To enhance Fenitrothion adsorption, a dimer of pesticide-binding peptide was also constructed and displayed. Compared with the peptide monomer, the dimer-displaying strain showed superior fenitrothion-binding ability. The performance of the strains was evaluated in artificial polluted soil, and their morphology was analyzed by FE-SEM. The results showed that these two kinds of constructed strains can adsorb Fenitrothion in contaminated environments with no cellular activity reduction. ARTICLE INFO.
Real-time monitoring of Fenitrothion in water samples using a silicon nanophotonic biosensor
Anal Chim Acta 2021 Apr 1;1152:338276.PMID:33648644DOI:10.1016/j.aca.2021.338276.
Due to the large quantities of pesticides extensively used and their impact on the environment and human health, a prompt and reliable sensing technique could constitute an excellent tool for in-situ monitoring. With this aim, we have applied a highly sensitive photonic biosensor based on a bimodal waveguide interferometer (BiMW) for the rapid, label-free, and specific quantification of Fenitrothion (FN) directly in tap water samples. After an optimization protocol, the biosensor achieved a limit of detection (LOD) of 0.29 ng mL-1 (1.05 nM) and a half-maximal inhibitory concentration (IC50) of 1.71 ng mL-1 (6.09 nM) using a competitive immunoassay and employing diluted tap water. Moreover, the biosensor was successfully employed to determine FN concentration in blind tap water samples obtaining excellent recovery percentages with a time-to-result of only 20 min without any sample pre-treatment. The features of the biosensor suggest its potential application for real time, fast and sensitive screening of FN in water samples as an analytical tool for the monitoring of the water quality.
[A case of death caused by Fenitrothion poisoning]
Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi 2021 Feb 20;39(2):147-149.PMID:33691373DOI:10.3760/cma.j.issn.120194-20191108-00515.
目的： 探讨急性甲维虫螨腈中毒的毒理学机制和影像学改变，为临床治疗提供依据。 方法： 对我院收治的1例急性甲维虫螨腈中毒患者的临床资料进行回顾性分析。 结果： 我院收治的1例甲维虫螨腈中毒患者因就诊不及时，经抢救无效死亡。 结论： 甲维虫螨腈中毒可导致严重神经系统损伤，临床上应高度重视并积极治疗。.