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Home >> Signaling Pathways

Signaling Pathways(信号通路)

  1. Cat.No. 产品名称 Information
  2. GC26035 Verubecestat (MK-8931) Trifluoroacetate

    MK-8931

     Verubecestat (MK-8931) Trifluoroacetate is a potent and selective beta-secretase inhibitor and BACE1 protein inhibitor or Beta-site APP-cleaving enzyme 1 inhibitor.
  3. GC26033 Veratrine

    Cevadine, Cevadin, Cevadene

     Veratridine (Cevadine, Cevadin, Cevadene), a steroidal alkaloid found in plants of the lily family, is a voltage-gated sodium channel activator. Veratridine induces anxiogenic-like behaviors in rats.
  4. GC26032 Varenicline (CP 526555) dihydrochloride

    Chantix, Champix,CP 526555 dihydrochloride

     Varenicline (CP 526555, Chantix, Champix,CP 526555 dihydrochloride) dihydrochloride is a potent, partial agonist of α4β2 nicotinic acetylcholine receptor (nAChR) and α3β4 nAChR with EC50 of 2.3 μM and 55 μM, respectively. Varenicline dihydrochloride is a potent, full agonist of α7 nAChRs with EC50 of 18 μM. Varenicline is a prescription medication used for smoking cessation.
  5. GC26029 Valbenazine tosylate

    NBI-98854

     Valbenazine tosylate (NBI-98854) is the tosylate salt of valbenazine, a vesicular monoamine transporter 2 (VMAT2) inhibitor with a Ki value of 150 nM while displaying no significant binding to VAMT1(Ki<10 μM).
  6. GC26027 V-0219 V-0219 is an orally active, positive allosteric modulator (PAM) of the glucagon-like peptide-1 receptor (GLP-1R), can be used for obesity-associated diabetes research.
  7. GC26017 UK-371804 HCl UK-371804 is a potent and selective urokinase-type plasmogen activator (uPA) inhibitor with excellent enzyme potency (Ki=10 nM) and selectivity profile (4000-fold versus tPA and 2700-fold versus plasmin).
  8. GC26016 TSHR antagonist S37 TSHR antagonist S37 is a selective and competitive antagonist of the thyrotropin receptor (TSHR).
  9. GC26012 Tris(2-ethylhexyl) phosphate Tris (2-ethylhexyl) phosphate, a clear, viscous liquid, is used as a component of vinyl stabilizers, grease additives, and flame-proofing compositions; however, it is used primarily as a plasticizer for vinyl plastic and synthetic rubber compounds.
  10. GC26011 Tris(2-butoxyethyl) phosphate

    TBEP

     Oral exposure to low-dose Tris (2-butoxyethyl) phosphate (TBEP) levels equivalent to tolerable daily intake may exacerbate allergic pulmonary inflammation by promoting a skewed T-helper 2 cell response, upregulation of ERα and dysregulation of both MLN and BM microenvironments.
  11. GC26007 Tridecafluorohexane-1-sulfonic acid potassium salt

    Potassium perfluorohexanesulfonate

     Tridecafluorohexane-1-sulfonic acid potassium salt是一种全氟阴离子表面活性剂，主要用作电镀中的铬雾抑制剂、润湿剂、氟蛋白泡沫灭火剂中的添加剂。
  12. GC26002 Trazodone

    AF-1161

     Trazodone (AF-1161) is a 5-HT 2A/2C receptor antagonist that is used as an antidepressant for treating major depressive disorder and anxiety disorders.
  13. GC26001 TPX-0046 TPX-0046 is a novel RET/SRC inhibitor with a mean IC50 of 17 nM for RETG810R in Ba/F3 cell proliferation assay
  14. GC26000 TP0427736 HCl TP0427736 is a potent inhibitor of ALK5 kinase activity with an IC50 of 2.72 nM and this effect is 300-fold higher than the inhibitory effect on ALK3 (IC50 = 836 nM for ALK3). It also inhibits Smad2/3 phosphorylation in A549 cells induced by TGF-β1 with an IC50 value of 8.68 nM.
  15. GC25996 THZ1 2HCl THZ1 is a covalent CDK7 inhibitor which has the unprecedented ability to target a remote cysteine residue located outside of the canonical kinase domain, providing an unanticipated means of achieving selectivity for CDK7.
  16. GC25994 Thonzylamine

    Neohetramine

     Thonzylamine (Neohetramine) is an antihistamine and anticholinergic drug.
  17. GC25993 TH263 TH-263, a diaryl sulfonamide derivative, is inactive toward both LIMK1 and LIMK2 and thus can be used as negative control for TH-257.
  18. GC25992 TG-89 TG-89 is an inhibitor of JAK2 with IC50 of 11.2 μM.
  19. GC25991 tetrathiomolybdate Tetrathiomolybdate (TM) is used in the clinic for the treatment of Wilson's disease by inducing dimerization of the metal-binding domain of the cellular copper efflux protein ATP7B (WLN4) through a unique sulfur-bridged Mo2S6O2 cluster.
  20. GC25986 TCPP

    Tris (clorisopropyl)phosphate

     TCPP (Tris(2-chloroethyl) phosphate) is a pervasive flame retardant.
  21. GC25985 TC-067533

    2-Methyl-N-(1S-naphthalen-2-yl-ethyl)-benzamide
  22. GC25982 Tanzisertib(CC-930)

    JNK-930, JNKI-1

     Tanzisertib (CC-930, JNK-930, JNKI-1) is kinetically competitive with ATP in the JNK-dependent phosphorylation of the protein substrate c-Jun and potent against all isoforms of JNK (Ki(JNK1) = 44 ± 3 nM, IC50(JNK1) = 61 nM, Ki(JNK2) = 6.2 ± 0.6 nM, IC50(JNK2) = 5 nM, IC50(JNK3) = 5 nM) and selective against MAP kinases ERK1 and p38a with IC50 of 0.48 and 3.4 μM respectively.
  23. GC25973 Sulfamide

    Sulfuric diamide

     Sulfamide (Sulfuric diamide) is used in organic chemistry for synthesis.
  24. GC25972 Sulfamethoxazole sodium Sulfamethoxazole sodium is an antibiotic used for bacterial infections.
  25. GC25969 SU5208

    3-[(Thien-2-yl)methylene]-2-indolinone

     SU5208(3-[(Thien-2-yl)methylene]-2-indolinone) is an inhibitor of vascular endothelial growth factor receptor-2 (VEGFR2).
  26. GC25968 STK414603
  27. GC25963 SR-0813 SR-0813 is a potent and selective ENL/AF9 YEATS domain inhibitor. SR-0813 has IC50 values of 25 and 311 nM for ENL YEATS domain and AF9 YEATS domain, respectively.
  28. GC25942 Sodium Glucoheptonate Dihydrate

    Sodium glucoheptonate

     Sodium glucoheptonate is used for cleaning metal, mercerizing, paint stripping, and aluminum etching.
  29. GC25941 Sodium acrylate Sodium acrylate是一种金属盐，可通过氢氧化钠和丙烯酸的酸碱反应制备。
  30. GC25940 SNS-314 SNS-314 is a potent and selective inhibitor of Aurora A, Aurora B and Aurora C with IC50 of 9 nM, 31 nM, and 3 nM, respectively. It is less potent to Trk A/B, Flt4, Fms, Axl, c-Raf and DDR2. Phase 1.
  31. GC25936 SLC13A5-IN-1 SLC13A5-IN-1 is a selective inhibitor of sodium-citrate co-transporter (SLC13A5/NaCT). It completely blocks the uptake of 14 C-citrate and has the potential for the treatment of metabolic and/or cardiovascular diseases.
  32. GC25935 Simufilam dihydrochloride

    PTI-125 dihydrochloride

     Simufilam (PTI-125) Dihydrochloride is a small molecule modulator that preferentially binds altered FLNA and restores its native conformation, restoring receptor and synaptic activities and reducing its α7nAChR/TLR4 associations and downstream pathologies.
  33. GC25913 Selective PI3Kδ Inhibitor 1 (compound 7n) Selective PI3Kδ Inhibitor 1 (compound 7n) is an inhibitor of PI3Kδ with an IC50 of 0.9 nM and >1000-fold selectivity against other class I PI3K isoforms [PI3K α/γ/β=3670/1460/21300 nM].
  34. GC25900 Scarlet 808 Scarlet 808 is a chemical dye.
  35. GC25899 SC-1

    1-(4-Chloro-3-(trifluoromethyl)phenyl)-3-(4-(4-cyanophenoxy)phenyl)urea, STAT3-IN-7

     SC-1 (1-(4-Chloro-3-(trifluoromethyl)phenyl)-3-(4-(4-cyanophenoxy)phenyl)urea, STAT3-IN-7), a Sorafenib analogue and potently inhibits the phosphorylation of STAT3, induces cell apoptosis through SHP-1 dependent STAT3 inactivation.
  36. GC25898 SB 200646

    SB 200646A

     SB 200646 (SB 200646A) is a potent, selective and oral-active antagonist of 5-HT2B/2C over 5-HT2A receptor with 50 fold selectivity. The pKi for rat 5-HT2C receptor, rat 5-HT2B receptor and rat 5-HT2A receptor are 6.9, 7.5 and 5.2, respectively. SB 200646 has electrophysiological and anxiolytic properties in vivo.
  37. GC25889 Santalol Santalol is a naturally occuring sesquiterpene that has antibacterial, anti-hyperglycaemic, anti inflammatory and antioxidant effects.
  38. GC25881 S961 S961 is a biosynthetic insulin receptor antagonist that inhibits cellular proliferation and colony formation in breast tumour cells.
  39. GC25869 RO495

    CS-2667

     RO495 (CS-2667) is a potent inhibitor of Non-receptor tyrosine-protein kinase 2 (TYK2).
  40. GC25867 Rilpivirine Hydrochloride

    TMC278

     Rilpivirine (TMC278), is a second-generation non-nucleoside reverse transcriptase inhibitor (NNRTI) with higher potency, longer half-life and reduced side-effect profile compared with older NNRTIs, such as efavirenz.
  41. GC25863 Riamilovir

    Triazavirin

     Riamilovir (Triazavirin) is a broad-spectrum antiviral drug candidate, which can be used for potential application against the Coronavirus 2019-nCoV.
  42. GC25848 RH01687 RH01687 is a potent β-cell protector that exhibits β-cell-protective activities against endoplasmic reticulum (ER) stress.
  43. GC25832 Raloxifene

    Keoxifene, Pharoxifene, LY-139481, LY-156758, CCRIS-7129

     Raloxifene (Keoxifene, Pharoxifene, LY-139481, LY-156758, CCRIS-7129) is a second generation selective estrogen receptor modulator (SERM) used to prevent osteoporosis in postmenopausal women.
  44. GC25812 Quinidine sulfate

    Chinidin Sodium, Pitayine Sodium, β-quinine Sodium, (+)-quinidine Sodium

    Quinidine (Chinidin, Pitayine, β-quinine, (+)-quinidine) acts as a blocker of voltage-gated sodium channels, also an antimuscarinic and antimalarial.
  45. GC25787 PRT-060318 2HCl

    PRT318

     PRT-060318 (PRT318) is a novel selective inhibitor of the Syk tyrosine kinase with an IC50 of 4 nM, as an approach to HIT treatment.
  46. GC25786 Propafenone

    SA-79

     Propafenone (SA-79) is an orally active sodium channel blocking agent and a beta-adrenoceptor (β-adrenergic receptor) antagonist. Propafenone offers a broad spectrum of activity in the treatment of cardiac arrhythmias.
  47. GC25785 Promethazine Promethazine is a potent histamine H1 receptor antagonist. Promethazine is a medication used in the management and treatment of allergic conditions, nausea and vomiting, motion sickness, and sedation. Promethazine exhibits antiparasitic properties.
  48. GC25784 Proflavine

    3,6-Diaminoacridine

     Proflavine (3,6-Diaminoacridine) is a disinfectant bacteriostatic against many gram-positive bacteria. It is a topical antiseptic used mainly in wound dressings.
  49. GC25782 Procaine penicillin G

    PGP, Penicillin G Procaine, Bicillin C-R

     Penicillin G Procaine (PGP, Penicillin G Procaine, Bicillin C-R), a crystalline complex combining penicillin G with procaine, is a β-lactam antibiotic.
  50. GC25780 Potassium thioacetate Potassium thioacetate is widely used as a sulfur source in the synthesis of sulfur-containing organic compounds. It has been employed for the synthesis of heterocycles, polymers, transition-metal ligands, nanoparticles, bioactive compounds and macromolecular inclusion complexes.
  51. GC25779 Potassium phosphate dibasic

    Dipotassium phosphate

     Potassium phosphate dibasic (Dipotassium phosphate, K2HPO4) is often used as a fertilizer, food additive, and buffering agent.

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