Signaling Pathways(信号通路)

Cat.No. 产品名称 Information

GC25778 Potassium 1-Naphthaleneacetate

KANU, Potassium alpha-naphthylacetate, α-Naphthaleneacetic Acid Potassium Salt, 1-NAA Potassium Salt

Potassium 1-Naphthaleneacetate (KANU, α-Naphthaleneacetic Acid Potassium Salt) is being studied as a synthetic growth factor that affects conidial germination, sporulation, mycelial growth, cell surface morphology, and the viability of certain fungal plant pathogens.

GC25774 Polytetrafluoroethylene

PTFE

Polytetrafluoroethylene (PTFE) is a biomedical material and has excellent non-stick properties with an exceptionally low coefficient of friction

GC25765 PMPA tetrasodium salt

PMPA sodium

PMPA tetrasodium salt (PMPA sodium) is a potent and selective inhibitor of glutamate carboxypeptidase 2 (GCP II/NAALADase).

GC25756 Pirenperone

R-47456, R-50656

Pirenperone (R-47456, R-50656), a quinazoline derivative, is a selective antagonist of SR-2A (5-HT2 serotonin receptor) when employed in low doses. Pirenperone behaves like a typical neuroleptic when used in higher doses (greater than 0.1 mg/kg).

GC25754 Piperaquine phosphate Piperaquine phosphate is an orally active bisquinolone antimalarial drug.

GC25743 PIM447 (LGH447) PIM447 (LGH447) is a novel pan-PIM kinase inhibitor with Ki values of 6 pM, 18 pM, 9 pM for PIM1, PIM2, PIM3 respectively. It also inhibits GSK3β, PKN1, and PKCτ, but at a significantly lower potency with IC50 between 1 and 5 μM (>105-fold differential relative to the Ki on PIMs). PIM447 induces apoptosis.

GC25728 PF-4136309

INCB8761, PF-04136309

PF-4136309 (INCB8761, PF-04136309) is a potent, selective, and orally bioavailable CCR2 antagonist with an IC50 of 5.2 nM for human CCR2.

GC25727 PF-06446846 PF-06446846 is an orally active proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitor. PF-06446846 selectively inhibits translation of PCSK9 by stalling the 80S ribosome in the proximity of codon region.

GC25726 PF-05221304

NSC 170984, R 6238, STAT5 Inhibitor III

PF-05221304 is an orally bioavailable, liver-targeted inhibitor of acetyl-CoA carboxylase (ACC), an enzyme that catalyzes the first committed step in de novo lipogenesis (DNL).

GC25723 Perindopril L-Arginine Perindopril L-Argininel is a prodrug that is metabolized in the liver to its active diacid metabolite perindoprilat, which is rapidly and extensively absorbed, and become one of the highest tissue angiotensin-converting enzyme (ACE) affinities among the ACE inhibitors.

GC25717 pentetate calcium trisodium hydrate

Ca-DTPA

pentetate calcium trisodium hydrate (Ca-DTPA) is an iron chelating agent.

GC25708 Paroxetine mesylate

BRL-29060A mesylate,FG-7051 mesylate

Paroxetine Mesylate(BRL-29060A mesylate,FG-7051 mesylate) is the mesylate salt form of paroxetine, a phenylpiperidine derivative and a selective serotonin reuptake inhibitor (SSRI) with antidepressant and anxiolytic properties.

GC25693 OX02983 OX02983 is a novel anthelmintic agent, actives against both egg and adult stages of Trichuris parasites, immobilising whipworm and reducing the ability of embryonated Trichuris muris eggs to establish infection in the mouse host.

GC25691 OTS514 hydrochloride OTS514 is a highly potent TOPK(T-LAK cell-originated protein kinase) inhibitor with an IC50 value of 2.6 nM. OTS514 induces cell cycle arrest and apoptosis.

GC25688 Ormetoprim Ormetoprim (OMP) is an antibiotic to prevent the spread of disease in freshwater aquaculture.

GC25679 Olanexidine Hydrochloride semihydrate

OPB-2045, OPB-2045G

Olanexidine (OPB-2045, OPB-2045G) is a monobiguanide compound with bactericidal activity.

GC25673 Obatoclax (GX15-070)

Obatoclax (GX15-070) is an antagonist of Bcl-2 with an Ki of 0

GC25672 Nortropine Hydrochloride

Nortropeno Hydrochloride

Nortropine Hydrochloride (Nortropeno) is a secondary metabolite of tropine derivative drugs, such as atropine and benztropine.

GC25671 NK01-63

Coronastat

NK01-63 (Coronastat) is a potent inhibitor of the SARS-CoV-2 3CL protease, which is a critical drug target for small molecule COVID-19, given its likely druggability and essentiality in the viral maturation and replication cycle.

GC25669 Nilotinib hydrochloride

AMN-107 HCl

Nilotinib hydrochloride (AMN-107) is the hydrochloride salt form of nilotinib, an orally bioavailable Bcr-Abl tyrosine kinase inhibitor with antineoplastic activity.

GC25663 Nebivolol

Bystolic,R 065824

Nebivolol (Bystolic,R 065824) is a β1 receptor blocker with nitric oxide-potentiating vasodilatory effect used in treatment of hypertension and also for left ventricular failure.

GC25662 N-Desmethyltamoxifen N-Desmethyltamoxifen, the major metabolite of Tamoxifen in humans and a ten-fold more potent protein kinase C (PKC) inhibitor than Tamoxifen, also is a potent regulator of ceramide metabolism in human AML cells, limiting ceramide glycosylation, hydrolysis, and sphingosine phosphorylation.

GC25661 N-butyl-N-(4-hydroxybutyl) nitrosamine

BBN, OH-BBN

N-butyl-N-(4-hydroxybutyl) nitrosamine (BBN, OH-BBN) is a model compound that induces high-grade, invasive tumors in the urinary bladder

GC25655 Mupirocin calcium

Pseudomonic acid A

Mupirocin Calcium (Pseudomonic acid A) is the calcium salt form of mupirocin, a natural crotonic acid derivative extracted from Pseudomonas fluorescens,which inhibits bacterial protein synthesis and is used as an antibiotic.

GC25651 MRT68921 HCl MRT68921 is a potent and dual autophagy kinase ULK1/2 inhibitor with IC50 of 2.9 nM and 1.1 nM, respectively.

GC25650 MRT67307 HCl MRT67307 is a potent and dual IKKε and TBK1 inhibitor with IC50 of 160 and 19 nM, respectively. MRT67307 potently inhibits ULK1 and ULK2 and blocks autophagy.

GC25648 MOTS-c MOTS-c, a mitochondria-derived peptide (MDP), exerts antinociceptive and anti-inflammatory effects through activating AMPK pathway and inhibiting MAP kinases-c-fos signaling pathway.

GC25640 Mometasone Furoate Hydrate

SCH 32088 hydrate

Mometasone Furoate (SCH 32088) Hydrate is a synthetic glucocorticoid with anti-inflammatory activity

GC25639 MM3122 MM3122 is a selective inhibitor of host cell serine protease TMPRSS2 (transmembrane protease serine 2) with IC50 of 0.34 nM against recombinant full-length TMPRSS2 protein.

GC25638 Miransertib (ARQ 092) HCl

Miransertib

Miransertib (ARQ 092) HCl is a novel, orally bioavailable and selective AKT pathway inhibitor exhibiting a manageable safety profile among patients with advanced solid tumors.

GC25636 MINA53 inhibitor (Compound 10) MINA53 inhibitor (Compound 10, 2-((3-Phenylpropyl)thio)-3,4-dihydro-4-oxopyrimidine-5-carboxylic Acid) is a first-in-class inhibitor of the ribosomal oxygenase MINA53 with an IC50 of 1

GC25631 Methyl 4-aminobutyrate HCl

GABA methyl ester

Methyl 4-aminobutanoate (GABA methyl ester) is a methyl ester resulting from the formal condensation of gamma-aminobutyric acid with methanol.

GC25630 Methyl 3-aminopyrazine-2-carboxylate Methyl 3-aminopyrazine-2-carboxylate is used in chemical synthesis.

GC25627 Menotropin

Human Menopausal Gonadotrophin

Menotropin (Human Menopausal Gonadotrophin) is a hormonally active medication for the treatment of fertility disturbances, which are extracted from the urine of postmenopausal women.

GC25626 MELK-8a Dihydrochloride MELK-8a Dihydrochloride is a novel inhibitor of maternal embryonic leucine zipper kinase (MELK) with an IC50 of 2 nM.

GC25624 MEISi-2 Dihydrochloride MEISi-2 Dihydrochloride is a potent MEIS inhibitor (MEISi) that significantly inhibits MEIS-luciferase reporters in vitro.The solubility of this product is not good, please choose carefully for cell experiments!

GC25622 MCC-7840

Emlenoflast

MCC7840 (Emlenoflast), a sulfonylurea, is a potent and selective inhibitor of NLRP3 inflammasome, with an IC50 of <100 nM.

GC25618 Maropitant citrate Maropitant citrate is a novel neurokinin type-1 (NK1) receptor antagonist with anti-inflammatory and analgesic properties

GC25605 Magnesium lactate trihydrate Magnesium lactate, the magnesium salt of lactic acid, is a mineral supplement that is added to some food and beverages as an acidity regulator.

GC25603 M2912

MSC2504877

M2912 (MSC2504877) is a very potent TNKS1/TNKS2 inhibitor (IC50=0.6 nM for TNKS1) with exquisite selectivity over other PARP family enzymes and favorable compound properties. This inhibitor potently modulates the Wnt/β-catenin pathway by elevating the levels of axin2 (EC50=17 nM) and tankyrase in DLD1 cells in a dose-dependent manner resulting in reduced cellular Wnt reporter activity.

GC25594 LY3405105 LY3405105 is an orally active CDK7 inhibitor with an IC50 of 92.8 nM. LY3405105 shows potential antineoplastic activity.

GC25593 LY3143921 hydrate LY3143921 hydrate is an orally administered ATP-competitive CDC7 inhibitor.

GC25583 Lobelin sulphate

Lobeline sulfate, Bantron

Lobelin sulphate (Lobeline sulfate, Bantron) is an alkaloid that has actions similar to nicotine on nicotinic cholinergic receptors but is less potent. It has a variety of therapeutic uses including in respiratory disorders, peripheral vascular disorders, insomnia, and smoking cessation.

GC25581 LM11A-31 LM11A-31 is a small molecule p75NTR Ligand that reverses cholinergic neurite dystrophy in alzheimer's diseasemousemodels with mid- to late-stage disease progression

GC25580 LLY-284 LLY-284 is the diastereomer of LLY-283, which is a potent and selective SAM-competitive chemical probe for PRMT5. LLY-284 is much less active than LLY-283 and can be used as a negative control for LLY-283.

GC25579 LL-37(human) LL-37, human is a 37-residue, amphipathic, cathelicidin-derived peptide, which exhibits a broad spectrum of antimicrobial activity.

GC25571 Levocetirizine

LCZ, (R)-Cetirizine

Levocetirizine (LCZ, (R)-Cetirizine), the R-enantiomer of cetirizine, is an antagonist of histamine H(1) receptor.

GC25569 Lerisetron

F 0930, F 0930RS

Lerisetron (F 0930, F 0930RS) is a 5-HT3 receptor antagonist with IC50 of 0.81μM.

GC25566 L-DAB HBR

L-Dab Hydrobromide, L-2,4-Diaminobutyric acid hydrobromide

L-DAB HBR (L-Dab Hydrobromide, L-2,4-Diaminobutyric acid hydrobromide) is an inhibitor of GABA (Gamma-aminobutyric acid) transaminase with IC50 of >500 μM

GC25563 Lasmiditan succinate

COL-144, LY573144

Lasmiditan succinate (COL-144, LY573144) is a novel, centrally acting, highly selective 5-HT(1F) receptor agonist (Ki=2.21 nM) without vasoconstrictor activity.