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Home >> Signaling Pathways

Signaling Pathways(信号通路)

  1. Cat.No. 产品名称 Information
  2. GC26063 WAY-340935

    VEGFR2-IN-2

     WAY-340935 (VEGFR2-IN-2) can inhibit the function of VEGFR2 and the anti-proliferative activity against the H460 cell line is produced partly by interaction of VEGFR protein.
  3. GC26062 WAY-328178 WAY-328178 is a bioactive compound.
  4. GC26061 WAY-328168 WAY-328168 is a bioactive compound.
  5. GC26060 WAY-328133 WAY-328133 is a bioactive compound.
  6. GC26059 WAY-323096
  7. GC26057 WAY-309236-A
  8. GC26056 WAY-303290

    GluR6 antagonist-1

     WAY-303290 (GluR6 antagonist-1) is a benzothiophene derivative acting as an ionotropic glutamate receptor 6 (GluR6) antagonist, which can be used for researching acute and chronic neurological disorders.
  9. GC26055 WAY-301398

    6-methoxynaphthalene

     WAY-301398 (6-methoxynaphthalene) can bind to protein kinase C (PKC).
  10. GC26054 WAY-299775 WAY- 299775 is a bioactive compound.
  11. GC26053 WAY-297848 WAY-297848 is a novel glucokinase activator with potential use as a drug for the prevention or treatment of hyperglycemia, diabetes, obesity, dyslipidemia, metabolic syndrome, etc.
  12. GC26052 WAY-297407 WAY-297407 is a bioactive compound.
  13. GC26051 WAY-296817
  14. GC26050 WAY-272077
  15. GC26049 WAY-119064 WAY-119064 is a potent glycogen synthase kinase-3β (GSK-3β) inhibitor with an IC50 value of 80.5 nM.
  16. GC26046 Waltonitone Waltonitone, an ursane-type pentacyclic triterpene extracted from Gentiana waltonii Burkill, exerts anti-tumor effect.
  17. GC26044 VPS34 inhibitor 1 (Compound 19)

    PIK-III analogue

     VPS34 inhibitor 1 (Compound 19, PIK-III analogue) is a potent and selective inhibitor of VPS34 with an IC50 of 15 nM.
  18. GC26035 Verubecestat (MK-8931) Trifluoroacetate

    MK-8931

     Verubecestat (MK-8931) Trifluoroacetate is a potent and selective beta-secretase inhibitor and BACE1 protein inhibitor or Beta-site APP-cleaving enzyme 1 inhibitor.
  19. GC26033 Veratrine

    Cevadine, Cevadin, Cevadene

     Veratridine (Cevadine, Cevadin, Cevadene), a steroidal alkaloid found in plants of the lily family, is a voltage-gated sodium channel activator. Veratridine induces anxiogenic-like behaviors in rats.
  20. GC26032 Varenicline (CP 526555) dihydrochloride

    Chantix, Champix,CP 526555 dihydrochloride

     Varenicline (CP 526555, Chantix, Champix,CP 526555 dihydrochloride) dihydrochloride is a potent, partial agonist of α4β2 nicotinic acetylcholine receptor (nAChR) and α3β4 nAChR with EC50 of 2.3 μM and 55 μM, respectively. Varenicline dihydrochloride is a potent, full agonist of α7 nAChRs with EC50 of 18 μM. Varenicline is a prescription medication used for smoking cessation.
  21. GC26029 Valbenazine tosylate

    NBI-98854

     Valbenazine tosylate (NBI-98854) is the tosylate salt of valbenazine, a vesicular monoamine transporter 2 (VMAT2) inhibitor with a Ki value of 150 nM while displaying no significant binding to VAMT1(Ki<10 μM).
  22. GC26027 V-0219 V-0219 is an orally active, positive allosteric modulator (PAM) of the glucagon-like peptide-1 receptor (GLP-1R), can be used for obesity-associated diabetes research.
  23. GC26017 UK-371804 HCl UK-371804 is a potent and selective urokinase-type plasmogen activator (uPA) inhibitor with excellent enzyme potency (Ki=10 nM) and selectivity profile (4000-fold versus tPA and 2700-fold versus plasmin).
  24. GC26016 TSHR antagonist S37 TSHR antagonist S37 is a selective and competitive antagonist of the thyrotropin receptor (TSHR).
  25. GC26012 Tris(2-ethylhexyl) phosphate Tris (2-ethylhexyl) phosphate, a clear, viscous liquid, is used as a component of vinyl stabilizers, grease additives, and flame-proofing compositions; however, it is used primarily as a plasticizer for vinyl plastic and synthetic rubber compounds.
  26. GC26011 Tris(2-butoxyethyl) phosphate

    TBEP

     Oral exposure to low-dose Tris (2-butoxyethyl) phosphate (TBEP) levels equivalent to tolerable daily intake may exacerbate allergic pulmonary inflammation by promoting a skewed T-helper 2 cell response, upregulation of ERα and dysregulation of both MLN and BM microenvironments.
  27. GC26007 Tridecafluorohexane-1-sulfonic acid potassium salt Tridecafluorohexane-1-sulfonic acid potassium salt is a perfluoroanionic surfactant, which is mainly used as a chromium mist inhibitor in electroplating, a wetting agent, and an additive in fluoroprotein foam fire extinguishing agents.DMSO is not recommended to dissolve platinum-based drugs, which can easily lead to drug inactivation.
  28. GC26002 Trazodone

    AF-1161

     Trazodone (AF-1161) is a 5-HT 2A/2C receptor antagonist that is used as an antidepressant for treating major depressive disorder and anxiety disorders.
  29. GC26001 TPX-0046 TPX-0046 is a novel RET/SRC inhibitor with a mean IC50 of 17 nM for RETG810R in Ba/F3 cell proliferation assay
  30. GC26000 TP0427736 HCl TP0427736 is a potent inhibitor of ALK5 kinase activity with an IC50 of 2.72 nM and this effect is 300-fold higher than the inhibitory effect on ALK3 (IC50 = 836 nM for ALK3). It also inhibits Smad2/3 phosphorylation in A549 cells induced by TGF-β1 with an IC50 value of 8.68 nM.
  31. GC25996 THZ1 2HCl THZ1 is a covalent CDK7 inhibitor which has the unprecedented ability to target a remote cysteine residue located outside of the canonical kinase domain, providing an unanticipated means of achieving selectivity for CDK7.
  32. GC25994 Thonzylamine

    Neohetramine

     Thonzylamine (Neohetramine) is an antihistamine and anticholinergic drug.
  33. GC25993 TH263 TH-263, a diaryl sulfonamide derivative, is inactive toward both LIMK1 and LIMK2 and thus can be used as negative control for TH-257.
  34. GC25992 TG-89 TG-89 is an inhibitor of JAK2 with IC50 of 11.2 μM.
  35. GC25991 tetrathiomolybdate Tetrathiomolybdate (TM) is used in the clinic for the treatment of Wilson's disease by inducing dimerization of the metal-binding domain of the cellular copper efflux protein ATP7B (WLN4) through a unique sulfur-bridged Mo2S6O2 cluster.
  36. GC25986 TCPP

    Tris (clorisopropyl)phosphate

     TCPP (Tris(2-chloroethyl) phosphate) is a pervasive flame retardant.
  37. GC25985 TC-067533

    2-Methyl-N-(1S-naphthalen-2-yl-ethyl)-benzamide
  38. GC25982 Tanzisertib(CC-930)

    JNK-930, JNKI-1

     Tanzisertib (CC-930, JNK-930, JNKI-1) is kinetically competitive with ATP in the JNK-dependent phosphorylation of the protein substrate c-Jun and potent against all isoforms of JNK (Ki(JNK1) = 44 ± 3 nM, IC50(JNK1) = 61 nM, Ki(JNK2) = 6.2 ± 0.6 nM, IC50(JNK2) = 5 nM, IC50(JNK3) = 5 nM) and selective against MAP kinases ERK1 and p38a with IC50 of 0.48 and 3.4 μM respectively.
  39. GC25973 Sulfamide

    Sulfuric diamide

     Sulfamide (Sulfuric diamide) is used in organic chemistry for synthesis.
  40. GC25972 Sulfamethoxazole sodium Sulfamethoxazole sodium is an antibiotic used for bacterial infections.
  41. GC25969 SU5208

    3-[(Thien-2-yl)methylene]-2-indolinone

     SU5208(3-[(Thien-2-yl)methylene]-2-indolinone) is an inhibitor of vascular endothelial growth factor receptor-2 (VEGFR2).
  42. GC25968 STK414603
  43. GC25963 SR-0813 SR-0813 is a potent and selective ENL/AF9 YEATS domain inhibitor. SR-0813 has IC50 values of 25 and 311 nM for ENL YEATS domain and AF9 YEATS domain, respectively.
  44. GC25942 Sodium Glucoheptonate Dihydrate

    Sodium glucoheptonate

     Sodium glucoheptonate is used for cleaning metal, mercerizing, paint stripping, and aluminum etching.
  45. GC25941 Sodium acrylate Sodium acrylate is a metal salt that can be prepared by an acid-base reaction between sodium hydroxide and acrylic acid.
  46. GC25940 SNS-314 SNS-314 is a potent and selective inhibitor of Aurora A, Aurora B and Aurora C with IC50 of 9 nM, 31 nM, and 3 nM, respectively. It is less potent to Trk A/B, Flt4, Fms, Axl, c-Raf and DDR2. Phase 1.
  47. GC25936 SLC13A5-IN-1 SLC13A5-IN-1 is a selective inhibitor of sodium-citrate co-transporter (SLC13A5/NaCT). It completely blocks the uptake of 14 C-citrate and has the potential for the treatment of metabolic and/or cardiovascular diseases.
  48. GC25935 Simufilam dihydrochloride

    PTI-125 dihydrochloride

     Simufilam (PTI-125) Dihydrochloride is a small molecule modulator that preferentially binds altered FLNA and restores its native conformation, restoring receptor and synaptic activities and reducing its α7nAChR/TLR4 associations and downstream pathologies.
  49. GC25913 Selective PI3Kδ Inhibitor 1 (compound 7n) Selective PI3Kδ Inhibitor 1 (compound 7n) is an inhibitor of PI3Kδ with an IC50 of 0.9 nM and >1000-fold selectivity against other class I PI3K isoforms [PI3K α/γ/β=3670/1460/21300 nM].
  50. GC25900 Scarlet 808 Scarlet 808 is a chemical dye.
  51. GC25899 SC-1

    1-(4-Chloro-3-(trifluoromethyl)phenyl)-3-(4-(4-cyanophenoxy)phenyl)urea, STAT3-IN-7

     SC-1 (1-(4-Chloro-3-(trifluoromethyl)phenyl)-3-(4-(4-cyanophenoxy)phenyl)urea, STAT3-IN-7), a Sorafenib analogue and potently inhibits the phosphorylation of STAT3, induces cell apoptosis through SHP-1 dependent STAT3 inactivation.

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