Signaling Pathways(信号通路)

Cat.No. 产品名称 Information

GC25898 SB 200646

SB 200646A

SB 200646 (SB 200646A) is a potent, selective and oral-active antagonist of 5-HT2B/2C over 5-HT2A receptor with 50 fold selectivity. The pKi for rat 5-HT2C receptor, rat 5-HT2B receptor and rat 5-HT2A receptor are 6.9, 7.5 and 5.2, respectively. SB 200646 has electrophysiological and anxiolytic properties in vivo.

GC25889 Santalol Santalol is a naturally occuring sesquiterpene that has antibacterial, anti-hyperglycaemic, anti inflammatory and antioxidant effects.

GC25881 S961 S961 is a biosynthetic insulin receptor antagonist that inhibits cellular proliferation and colony formation in breast tumour cells.

GC25869 RO495

CS-2667

RO495 (CS-2667) is a potent inhibitor of Non-receptor tyrosine-protein kinase 2 (TYK2).

GC25867 Rilpivirine Hydrochloride

TMC278

Rilpivirine (TMC278), is a second-generation non-nucleoside reverse transcriptase inhibitor (NNRTI) with higher potency, longer half-life and reduced side-effect profile compared with older NNRTIs, such as efavirenz.

GC25863 Riamilovir

Triazavirin

Riamilovir (Triazavirin) is a broad-spectrum antiviral drug candidate, which can be used for potential application against the Coronavirus 2019-nCoV.

GC25848 RH01687 RH01687 is a potent β-cell protector that exhibits β-cell-protective activities against endoplasmic reticulum (ER) stress.

GC25838 RBPJ Inhibitor-1 (RIN1) RBPJ Inhibitor-1 (RIN1) is a potent inhibitor of the transcription factor RBPJ that disrupts the interaction between NOTCH and RBPJ.

GC25832 Raloxifene

Keoxifene, Pharoxifene, LY-139481, LY-156758, CCRIS-7129

Raloxifene (Keoxifene, Pharoxifene, LY-139481, LY-156758, CCRIS-7129) is a second generation selective estrogen receptor modulator (SERM) used to prevent osteoporosis in postmenopausal women.

GC25812 Quinidine sulfate

Chinidin Sodium, Pitayine Sodium, β-quinine Sodium, (+)-quinidine Sodium

Quinidine (Chinidin, Pitayine, β-quinine, (+)-quinidine) acts as a blocker of voltage-gated sodium channels, also an antimuscarinic and antimalarial.

GC25811 Quinacrine Dihydrochloride Dihydrate

Mepacrine Dihydrochloride Dihydrate

Quinacrine (Mepacrine) is a dye of the acridine family that has been widely used as staining agents for DNA and model compounds for intercalators in numerous biophysical studies. It is also an antimalarial drug.

GC25787 PRT-060318 2HCl

PRT318

PRT-060318 (PRT318) is a novel selective inhibitor of the Syk tyrosine kinase with an IC50 of 4 nM, as an approach to HIT treatment.

GC25786 Propafenone

SA-79

Propafenone (SA-79) is an orally active sodium channel blocking agent and a beta-adrenoceptor (β-adrenergic receptor) antagonist. Propafenone offers a broad spectrum of activity in the treatment of cardiac arrhythmias.

GC25785 Promethazine Promethazine is a potent histamine H1 receptor antagonist. Promethazine is a medication used in the management and treatment of allergic conditions, nausea and vomiting, motion sickness, and sedation. Promethazine exhibits antiparasitic properties.

GC25784 Proflavine

3,6-Diaminoacridine

Proflavine (3,6-Diaminoacridine) is a disinfectant bacteriostatic against many gram-positive bacteria. It is a topical antiseptic used mainly in wound dressings.

GC25782 Procaine penicillin G

PGP, Penicillin G Procaine, Bicillin C-R

Penicillin G Procaine (PGP, Penicillin G Procaine, Bicillin C-R), a crystalline complex combining penicillin G with procaine, is a β-lactam antibiotic.

GC25780 Potassium thioacetate Potassium thioacetate is widely used as a sulfur source in the synthesis of sulfur-containing organic compounds. It has been employed for the synthesis of heterocycles, polymers, transition-metal ligands, nanoparticles, bioactive compounds and macromolecular inclusion complexes.

GC25779 Potassium phosphate dibasic

Dipotassium phosphate

Potassium phosphate dibasic (Dipotassium phosphate, K2HPO4) is often used as a fertilizer, food additive, and buffering agent.

GC25778 Potassium 1-Naphthaleneacetate

KANU, Potassium alpha-naphthylacetate, α-Naphthaleneacetic Acid Potassium Salt, 1-NAA Potassium Salt

Potassium 1-Naphthaleneacetate (KANU, α-Naphthaleneacetic Acid Potassium Salt) is being studied as a synthetic growth factor that affects conidial germination, sporulation, mycelial growth, cell surface morphology, and the viability of certain fungal plant pathogens.

GC25774 Polytetrafluoroethylene

PTFE

Polytetrafluoroethylene (PTFE) is a biomedical material and has excellent non-stick properties with an exceptionally low coefficient of friction

GC25765 PMPA tetrasodium salt

PMPA sodium

PMPA tetrasodium salt (PMPA sodium) is a potent and selective inhibitor of glutamate carboxypeptidase 2 (GCP II/NAALADase).

GC25756 Pirenperone

R-47456, R-50656

Pirenperone (R-47456, R-50656), a quinazoline derivative, is a selective antagonist of SR-2A (5-HT2 serotonin receptor) when employed in low doses. Pirenperone behaves like a typical neuroleptic when used in higher doses (greater than 0.1 mg/kg).

GC25754 Piperaquine phosphate Piperaquine phosphate is an orally active bisquinolone antimalarial drug.

GC25743 PIM447 (LGH447) PIM447 (LGH447) is a novel pan-PIM kinase inhibitor with Ki values of 6 pM, 18 pM, 9 pM for PIM1, PIM2, PIM3 respectively. It also inhibits GSK3β, PKN1, and PKCτ, but at a significantly lower potency with IC50 between 1 and 5 μM (>105-fold differential relative to the Ki on PIMs). PIM447 induces apoptosis.

GC25728 PF-4136309

INCB8761, PF-04136309

PF-4136309 (INCB8761, PF-04136309) is a potent, selective, and orally bioavailable CCR2 antagonist with an IC50 of 5.2 nM for human CCR2.

GC25727 PF-06446846 PF-06446846 is an orally active proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitor. PF-06446846 selectively inhibits translation of PCSK9 by stalling the 80S ribosome in the proximity of codon region.

GC25726 PF-05221304

NSC 170984, R 6238, STAT5 Inhibitor III

PF-05221304 is an orally bioavailable, liver-targeted inhibitor of acetyl-CoA carboxylase (ACC), an enzyme that catalyzes the first committed step in de novo lipogenesis (DNL).

GC25723 Perindopril L-Arginine Perindopril L-Argininel is a prodrug that is metabolized in the liver to its active diacid metabolite perindoprilat, which is rapidly and extensively absorbed, and become one of the highest tissue angiotensin-converting enzyme (ACE) affinities among the ACE inhibitors.

GC25717 pentetate calcium trisodium hydrate

Ca-DTPA

pentetate calcium trisodium hydrate (Ca-DTPA) is an iron chelating agent.

GC25708 Paroxetine mesylate

BRL-29060A mesylate,FG-7051 mesylate

Paroxetine Mesylate(BRL-29060A mesylate,FG-7051 mesylate) is the mesylate salt form of paroxetine, a phenylpiperidine derivative and a selective serotonin reuptake inhibitor (SSRI) with antidepressant and anxiolytic properties.

GC25693 OX02983 OX02983 is a novel anthelmintic agent, actives against both egg and adult stages of Trichuris parasites, immobilising whipworm and reducing the ability of embryonated Trichuris muris eggs to establish infection in the mouse host.

GC25691 OTS514 hydrochloride OTS514 is a highly potent TOPK(T-LAK cell-originated protein kinase) inhibitor with an IC50 value of 2.6 nM. OTS514 induces cell cycle arrest and apoptosis.

GC25688 Ormetoprim Ormetoprim (OMP) is an antibiotic to prevent the spread of disease in freshwater aquaculture.

GC25679 Olanexidine Hydrochloride semihydrate

OPB-2045, OPB-2045G

Olanexidine (OPB-2045, OPB-2045G) is a monobiguanide compound with bactericidal activity.

GC25673 Obatoclax (GX15-070)

Obatoclax (GX15-070) is an antagonist of Bcl-2 with an Ki of 0

GC25672 Nortropine Hydrochloride

Nortropeno Hydrochloride

Nortropine Hydrochloride (Nortropeno) is a secondary metabolite of tropine derivative drugs, such as atropine and benztropine.

GC25671 NK01-63

Coronastat

NK01-63 (Coronastat) is a potent inhibitor of the SARS-CoV-2 3CL protease, which is a critical drug target for small molecule COVID-19, given its likely druggability and essentiality in the viral maturation and replication cycle.

GC25669 Nilotinib hydrochloride

AMN-107 HCl

Nilotinib hydrochloride (AMN-107) is the hydrochloride salt form of nilotinib, an orally bioavailable Bcr-Abl tyrosine kinase inhibitor with antineoplastic activity.

GC25663 Nebivolol

Bystolic,R 065824

Nebivolol (Bystolic,R 065824) is a β1 receptor blocker with nitric oxide-potentiating vasodilatory effect used in treatment of hypertension and also for left ventricular failure.

GC25662 N-Desmethyltamoxifen N-Desmethyltamoxifen, the major metabolite of Tamoxifen in humans and a ten-fold more potent protein kinase C (PKC) inhibitor than Tamoxifen, also is a potent regulator of ceramide metabolism in human AML cells, limiting ceramide glycosylation, hydrolysis, and sphingosine phosphorylation.

GC25661 N-butyl-N-(4-hydroxybutyl) nitrosamine

BBN, OH-BBN

N-butyl-N-(4-hydroxybutyl) nitrosamine (BBN, OH-BBN) is a model compound that induces high-grade, invasive tumors in the urinary bladder

GC25655 Mupirocin calcium

Pseudomonic acid A

Mupirocin Calcium (Pseudomonic acid A) is the calcium salt form of mupirocin, a natural crotonic acid derivative extracted from Pseudomonas fluorescens,which inhibits bacterial protein synthesis and is used as an antibiotic.

GC25651 MRT68921 HCl MRT68921 is a potent and dual autophagy kinase ULK1/2 inhibitor with IC50 of 2.9 nM and 1.1 nM, respectively.

GC25650 MRT67307 HCl MRT67307 is a potent and dual IKKε and TBK1 inhibitor with IC50 of 160 and 19 nM, respectively. MRT67307 potently inhibits ULK1 and ULK2 and blocks autophagy.

GC25648 MOTS-c MOTS-c, a mitochondria-derived peptide (MDP), exerts antinociceptive and anti-inflammatory effects through activating AMPK pathway and inhibiting MAP kinases-c-fos signaling pathway.

GC25640 Mometasone Furoate Hydrate

SCH 32088 hydrate

Mometasone Furoate (SCH 32088) Hydrate is a synthetic glucocorticoid with anti-inflammatory activity

GC25639 MM3122 MM3122 is a selective inhibitor of host cell serine protease TMPRSS2 (transmembrane protease serine 2) with IC50 of 0.34 nM against recombinant full-length TMPRSS2 protein.

GC25638 Miransertib (ARQ 092) HCl

Miransertib

Miransertib (ARQ 092) HCl is a novel, orally bioavailable and selective AKT pathway inhibitor exhibiting a manageable safety profile among patients with advanced solid tumors.

GC25636 MINA53 inhibitor (Compound 10) MINA53 inhibitor (Compound 10, 2-((3-Phenylpropyl)thio)-3,4-dihydro-4-oxopyrimidine-5-carboxylic Acid) is a first-in-class inhibitor of the ribosomal oxygenase MINA53 with an IC50 of 1

GC25631 Methyl 4-aminobutyrate HCl

GABA methyl ester

Methyl 4-aminobutanoate (GABA methyl ester) is a methyl ester resulting from the formal condensation of gamma-aminobutyric acid with methanol.