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Home >> Signaling Pathways >> Angiogenesis

Angiogenesis(血管生成)

  1. Cat.No. 产品名称 Information
  2. GC37034 PT2977

    PT2977; MK-6482

     PT2977 (Belzutifan, MK-6482), an orally active and selective HIF-2α inhibitor, increases potency and improves pharmacokinetic profile, providing a potential treatment for clear cell renal cell carcinoma (ccRCC).
  3. GC36861 PCI 29732

    4-氨基-1-环戊基-3-(4-苯氧基苯基)-1H-吡唑并[3,4-D]嘧啶

     A multi-kinase inhibitor
  4. GC36821 OSU-T315 OSU-T315 (ILK-IN-2) is a potent Integrin-Linked Kinase (ILK) inhibitor with IC50 of 0.6 μM. OSU-T315 induces autophagy and apoptosis, both of which are integral to its antiproliferative activity. OSU-T315 exhibits anti-tumor activity.
  5. GC36661 MT-802 MT-802 is a potent PROTAC that induces Bruton's tyrosine kinase (BTK) knockdown. MT-802 recruits BTK to the cereblon E3 ubiquitin ligase complex to trigger BTK ubiquitination and degradation via the proteasome. MT-802 has potential for treatment of C481S mutant chronic lymphocytic leukemia (CLL).
  6. GC36500 LXW7 LXW7 是一种八聚二硫环肽，为整合素 αvβ3 的配体，能够有效、特异性地靶作用于内皮祖细胞 (EPCs) 和内皮细胞 (ECs)。在 ECs 细胞中，LXW7 可增强 VEGFR-2 的磷酸化和 ERK1/2 的活化。
  7. GC36289 Ibrutinib-biotin

    依鲁替尼-生物素

     Ibrutinib-biotin 是一种由 Ibrutinib 通过长链接头连接到生物素上组成的探针，具体可参考 WO2014059368A1 中 Compound 1-5，抑制 BTK，IC50 值为 0.755-1.02 nM。
  8. GC36127 GDC-0834 Racemate

    N-[3-[6-[[4-(1,4-二甲基-3-氧代-2-哌嗪基)苯基]氨基]-4,5-二氢-4-甲基-5-氧代-2-吡嗪基]-2-甲基苯基]-4,5,6,7-四氢苯并[B]噻吩-2-甲酰胺

     GDC-0834 Racemate 是 GDC-0834 的外消旋体形式，它是一种有效的选择性 BTK 抑制剂，在生化和细胞试验中的体外 IC50 分别为 5.9 和 6.4 nM。
  9. GC36125 GB-110 GB-110 是一种有效的，具有口服活性的，非肽类的 protease activated receptor 2 (PAR2) 激动剂，选择性诱导 PAR2 介导的 HT29 细胞内 Ca2+ 释放，EC50 值为 0.28 μM。
  10. GC35684 CHMFL-EGFR-202 CHMFL-EGFR-202 是一种有效、不可逆的表皮生长因子受体 (EGFR) 突变型激酶抑制剂， 对 耐药突变型 EGFR T790M 和 WT EGFR 激酶作用的 IC50 值分别为 5.3 nM 和 8.3 nM。在细胞中，CHMFL-EGFR-202 对 EGFR L858R/T790M 的选择性是 EGFR 野生型的 10 倍。CHMFL-EGFR-202 以 “DFG-in-C-helix-out” 的不活跃结合构象形式共价结合 EGFR，对 EGFR 突变体驱动的非小细胞肺癌 (NSCLC) 细胞株具有较强的抗增殖作用。
  11. GC35683 CHMFL-BTK-01 CHMFL-BTK-01 (compound 9) 高度选择性的、不可逆的 BTK 抑制剂，IC50 值为 7 nM。CHMFL-BTK-01 (compound 9) 可有效抑制BTK Y223 的自磷酸化。
  12. GC35563 Btk inhibitor 1 R enantiomer hydrochloride

    3-(4-苯氧基苯基)-1-(3R)-3-哌啶基-1H-吡唑并[3,4-D]嘧啶-4-胺盐酸盐(1:1)

     Btk inhibitor 1 R enantiomer hydrochloride 是依鲁替尼的杂质。 IBT6A 可用于 IBT6A 依鲁替尼二聚体和 IBT6A 加合物的合成。 Ibrutinib 是一种选择性、不可逆的 Btk 抑制剂，IC50 为 0.5 nM。
  13. GC35562 Btk inhibitor 1 hydrochloride Btk inhibitor 1 hydrochloride 是 Btk inhibitor 1 R enantiomer 的消旋体. Btk inhibitor 1 R enantiomer (参考文献中的化合物14) 可用于合成 Ibrutinib 和基于 Ibrutinib 的活性探针 (ABP)。Ibrutinib 是一种共价且不可逆的 BTK 抑制剂。
  14. GC35561 Btk inhibitor 1 (Rac)-IBT6A (BTK inhibitor 1) is a racemate of IBT6A and an impurity of Ibrutinib, which is a Btk inhibitor (IC50=0.5 nM), and can be used in the synthesis of IBT6A Ibrutinib dimer and IBT6A adduct.
  15. GC35230 Acetylarenobufagin

    乙酰沙蟾毒精

     Acetylarenobufagin 是一种类固醇缺氧诱导因子-1 (HIF-I) 调节剂。
  16. GC45269 (±)10(11)-DiHDPA

    (±)10,11-DiHDPE

     An epoxygenase metabolite of DHA
  17. GC45054 Tie2 Inhibitor 7 Blocks Tie2 kinase activity
  18. GC44966 Sucrose octasulfate (potassium salt)

    蔗糖八硫酸酯钾

     An alkaline aluminum?sucrose complex
  19. GC44956 Streptochlorin

    3-(4-氯-5-恶唑基)-1H-吲哚

     A bacterial metabolite with diverse biological activities
  20. GC44800 Quininib A CysLT1 and CysLT2 receptor antagonist
  21. GC44584 PD 168368 An antagonist of NMB receptors
  22. GC44475 NVP-BEZ235 (hydrochloride)

    Dactolisib

     Dual inhibitor of PI3K and mTOR
  23. GC44465 NSC 12

    NSC 172285

     An FGF inhibitor
  24. GC44358 Nebivolol O-β-D-Glucuronide An active metabolite of nebivolol
  25. GC44290 NAADP (sodium salt)

    Nicotinic acid adenine dinucleotide phosphate

    A secondary messenger that induces calcium mobilization
  26. GC43803 HA-1077 (hydrochloride)

    盐酸法舒地尔,HA-1077 dihydrochloride; AT-877 dihydrochloride

     A ROCK inhibitor
  27. GC43732 Ganglioside GM3 Mixture (sodium salt)

    单唾液神经节苷酯GM3; Hematoside; Sialosyllactosylceramide

     A mixture of ganglioside GM3
  28. GC43727 Ganglioside GD1a mixture (sodium salt)

    双唾液酸神经节苷酯GD1A,Ganglioside B1

     A mixture of ganglioside GD1a
  29. GC43515 D-myo-Inositol-1,3,4,5,6-pentaphosphate (sodium salt)

    Ins(1,3,4,5,6)P5, 1,3,4,5,6IP5

     An anticancer inositol phosphate
  30. GC43514 D-myo-Inositol-1,3,4,5,6-pentaphosphate (ammonium salt)

    Ins(1,3,4,5,6)P5, 1,3,4,5,6IP5 (sodium salt)

     An anticancer inositol phosphate
  31. GC43198 CAY10717 A multi-targeted kinase inhibitor
  32. GC42887 Axitinib Sulfoxide

    阿西替尼杂质A

     A major inactive metabolite of axitinib
  33. GC42409 4-hydroxy Nebivolol (hydrochloride) A major metabolite of nebivolol
  34. GC41655 (±)19(20)-EDP Ethanolamide

    19,20-DHEA epoxide, 19,20-epoxy Docosapentaenoic Acid Ethanolamide, 19,20-EDP-EA, 19,20-EDP epoxide

     An ω-3 endocannabinoid epoxide and CB receptor agonist
  35. GC41653 (±)16(17)-DiHDPA An epoxygenase metabolite of DHA
  36. GC41648 (±)13(14)-DiHDPA

    13(14)-DiHDPA, 13(14)-DiHDoPE, 13,14-DiHDPE

     A metabolite of DHA
  37. GC41625 Oroxylin A

    千层纸素A; Baicalein 6-methyl ether; 6-Methoxybaicalein

     A flavonoid with diverse biological activities
  38. GC41212 (±)10(11)-EpDPA

    (±)10,11-EDP, (±)10,11-EpDPE, (±)10,11-epoxy DPA, (±)10,11-epoxy Docosapentaenoic Acid

     A DHA epoxygenase metabolite
  39. GC41203 (±)7(8)-EpDPA

    (±)7,8-EDP, (±)7,8-EpDPE, (±)7,8-epoxy DPA, (±)7,8-epoxy Docosapentaenoic Acid

     A DHA epoxygenase metabolite
  40. GC41191 (±)13(14)-EpDPA

    13,14-EpDPE

     A DHA epoxygenase metabolite
  41. GC40963 Spirolaxine A phthalide antibacterial agent
  42. GC40865 LYG-202 A synthetic flavonoid with anticancer and anti-angiogenic activities
  43. GC40466 (±)11(12)-EET

    11,12-EET

     A racemic version of a CYP450 metabolite of arachidonic acid
  44. GC34709 PF-06250112 PF-06250112是一种有效的、高度选择性、口服有效的BTK抑制剂，IC50值为0.5nM，对BMX非受体酪氨酸激酶和TEC同样有抑制作用，IC50值分别为0.9nM和1.2nM。
  45. GC34595 GN44028 GN44028 是一种有效且具有口服活性的缺氧诱导因子 (HIF)-1α 抑制剂，IC50 为 14 nM。 GN44028 抑制缺氧诱导的 HIF-1α 转录活性，而不抑制 HIF-1α mRNA 表达、HIF-1α 蛋白积累或 HIF-1α/HIF-1β 异二聚化。 GN44028可用于癌症研究。
  46. GC40213 Regorafenib-13C-d3

    瑞戈非尼-13C-D3,BAY 73-4506-13C,d3

     An internal standard for the quantification of regorafenib
  47. GC40085 Pazopanib-d6

    培唑帕尼-d6,GW786034-d6

     An internal standard for the quantification of pazopanib
  48. GC34402 RGD Trifluoroacetate

    (S)-2-(2-((S)-2-氨基-5-胍基戊酰胺基)乙酰氨基)琥珀酸三氟乙酸盐

     RGDTrifluoroacetate是一种三肽，能够有效的引起细胞黏着，定位某种特定细胞系并产生特定的细胞反应；RGDTrifluoroacetate能够与integrins结合。
  49. GC34301 ILK-IN-2

    OSU-T315 analog

     An ILK inhibitor
  50. GC34265 GRGDSP TFA GRGDSP(TFA)是一种整联蛋白(integrin)抑制剂。
  51. GC34211 Vedolizumab

    维多珠单抗; Anti-Human lymphocyte α4β7 integrin, Humanized Antibody

     Vedolizumab (anti-α4β7-integrin) is a humanized IgG1 monoclonal antibody that targets the α4β7 integrin for the treatment of ulcerative colitis and Crohn's disease.

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