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Home >> Signaling Pathways >> Angiogenesis

Angiogenesis(血管生成)

  1. Cat.No. 产品名称 Information
  2. GC31498 TP0463518 A pan HIF-PH inhibitor
  3. GC31358 HIF-2α-IN-1 HIF-2α-IN-1是一种HIF-2α抑制剂,IC50值小于500nM。
  4. GC31339 PRN1008

    PRN1008

     PRN1008 (Rilzabrutinib) is a reversible covalent, selective and oral active inhibitor of Bruton’s Tyrosine Kinase (BTK), with an IC50 of 1.3 nM.
  5. GC31230 Dencichin (Dencichine)

    三七素; Dencichin; ODAP

     Dencichin是一种最初从三七中提取的非蛋白质氨基酸，可以抑制HIF-脯氨酰羟化酶2（PHD-2）的活性。
  6. GC30263 Glucosamine (D-Glucosamine)

    氨基葡萄糖; D-Glucosamine; Chitosamine

     Glucosamine (2-amino-2-deoxy-D-glucose) is an amino sugar and a prominent precursor in the biochemical synthesis of glycosylated proteins and lipids. It is commonly used as a treatment for osteoarthritis. Glucosamine（GS） treatment selectively downregulates HIF-1α at the protein level in YD-8 cells via interference of production of the citric acid cycle metabolites.
  7. GC30223 Gly-Arg-Gly-Asp-Ser Gly-Arg-Gly-Asp-Ser是一种五肽，构成了糖蛋白，骨桥蛋白与细胞的结合域。
  8. GC30155 PCI-33380

    PCI-33380是布鲁顿酪氨酸激酶(BTK)的不可逆抑制剂(荧光探针)。
  9. GC30111 Cyclo(RADfK) Cyclo(RADfK)是选择性α(v)β(3)整合素配体,广泛用于新血管生成的研究,治疗和诊断。
  10. GC19333 BTK IN-1

    SNS062 analog

     A BTK inhibitor
  11. GC19251 MK-8617 A HIF-PH1, -2, and -3 inhibitor
  12. GC19222 Lifitegrast

    立他司特; SAR 1118; SHP-606

     An inhibitor of the LFA-1/ICAM-1 interaction
  13. GC19167 GLPG0187

    GLPG0187,一种广谱的INTEGRIN受体拮抗剂,具有抗肿瘤活性

     An αν integrin receptor antagonist
  14. GC19162 GDC-0853

    GDC-0853

     A BTK inhibitor
  15. GC19128 E7820

    ER68203-00

     An angiogenesis inhibitor with anticancer activity
  16. GC18717 BMS 986120 A selective PAR4 antagonist
  17. GC18616 MMP-8 Inhibitor I

    Matrix Metalloproteinase-8 Inhibitor I

     A selective inhibitor of MMP-8
  18. GC18608 MMP-2/MMP-9 Inhibitor II

    Matrix Metalloproteinase-2/Matrix Metalloproteinase-9 Inhibitor II

     A dual inhibitor of MMP-2 and MMP-9
  19. GC18236 Echinomycin

    醌霉素A,Antibiotic A 654I； NSC 13502； NSC 526417； Quinomycin A； SK 302B

     An inhibitor of HIF-1-mediated gene transcription
  20. GC18152 AZ-3451

    (S)-2-(6-溴苯并[D][1,3]二氧杂环戊烯-5-基)-N-(4-氰基苯基)-1-(1-环己基乙基)-1H-苯并[D]咪唑-5-甲酰胺

     A PAR2 antagonist
  21. GC16811 Vadadustat

    伐度司他,PG-1016548; AKB-6548

     An inhibitor of HIF-PH2 and HIF-PH3
  22. GC16195 2,4-DPD

    2,4-吡啶二甲酸乙酯,2,4-Diethylpyridine dicarboxylate

     A cell permeable, competitive inhibitor of HIF-PH
  23. GC15379 JNJ-42041935

    HIF-PHD Inhibitor II

     A selective inhibitor of HIF-PH enzymes
  24. GC12255 IOX4 A selective, bioavailable inhibitor of HIF-PH2
  25. GC12487 Adaptaquin

    HIF prolyl hydroxylase inhibitor

     An inhibitor of HIF-PH2
  26. GC17358 Octyl-α-ketoglutarate

    α-KG octyl ester

     A cell-permeable form of α-ketoglutarate
  27. GC14282 3-acetyl-11-keto-β-Boswellic Acid

    11-羰基-Β-乙酰乳香酸,3-O-acetyl-11-keto-β-Boswellic acid,AKBA

     A selective 5-LO inhibitor
  28. GC15453 ACP-196

    阿卡替尼,ACP-196

     A BTK inhibitor
  29. GC16647 Daprodustat(GSK1278863)

    达普司他,GSK1278863

     A HIF-PH1, -2, and -3 inhibitor
  30. GC13923 Cyclo(RGDyK) trifluoroacetate Cyclo(RGDyK) 是一种有效的选择性 αVβ3 整合素抑制剂，IC50 为 20 nM。
  31. GC11031 PX-478 2HCl PX-478是一种选择性抑制剂，可以抑制常规和低氧诱导的HIF-1α水平。
  32. GC14143 SB273005

    SB273005INTEGRIN抑制剂

     SB273005 是一种有效的非肽类和口服活性整合素拮抗剂，对 αvβ3 受体和 αvβ5 受体的 Kis 分别为 1.2 nM 和 0.3 nM。
  33. GC12821 Oltipraz

    奥替普拉; RP 35972; NSC 347901

     A Nrf2 and CAR activator
  34. GC13219 ONO-4059

    GS-4059 analog

     A derivative of ONO-4059
  35. GC10046 Molidustat (BAY85-3934)

    BAY 85-3934

     A pan-HIF-PH inhibitor
  36. GC14857 LFM-A13 A BTK inhibitor
  37. GC16638 FG2216

    IOX3; YM311

     An inhibitor of HIF-PH2
  38. GC13050 CWHM-12 An inhibitor of αv integrins
  39. GC17263 Leukadherin 1 An allosteric activator of CD11b/CD18
  40. GC12037 TC-I 15 TC-I 15 (TC-I-15) 是一种变构的胶原结合整合素 α2β1 抑制剂，对 GFOGER 和 GLOGEN 的 IC50 值分别为 26.8 μM 和 0.4 μM。
  41. GC18025 TCS 2314 TCS 2314 (compound 3) 是具有口服活性和选择性的甚晚期抗原 4 (VLA-4, α4β1, CD49d/CD29) 拮抗剂，IC50 为 4.4 nM。
  42. GC14208 BIO 5192 BIO 5192 是一种选择性有效的整合素 α4β1 (VLA-4) 抑制剂 (Kd\u003c10 pM)。
  43. GC14795 RWJ 50271 RWJ 50271 是一种选择性和口服活性的淋巴细胞功能相关抗原-1/细胞间粘附分子-1（LFA-1/ICAM-1）相互作用的抑制剂，IC50 为 5.0 μM（HL60 细胞）。
  44. GC15199 OGT 2115 An inhibitor of heparanase
  45. GC10291 SCH 79797 dihydrochloride An antagonist of PAR1
  46. GC17631 Combretastatin A4

    康普瑞汀; CRC 87-09

     A potent inhibitor of tubulin polymerization
  47. GC13951 GR 144053 trihydrochloride platelet fibrinogen receptor glycoprotein IIb/IIIa (GpIIb/IIIa) antagonist
  48. GC11753 HSDVHK-NH2

    P11

    HSDVHK-NH2 是整合素 αvβ3-玻璃体结合蛋白的互作抑制剂，其 IC50 值为 1.74 pg/mL (2.414 pM)。
  49. GC16107 Obtustatin 整合素 α1β1 抑制剂
  50. GC16190 LDV FITC fluorescent ligand that binds to the α4β1 integrin (VLA-4)
  51. GC17236 Echistatin, α1 isoform Echistatin, α1 异构体是最小的活性 RGD 蛋白，属于源自蛇毒的去整合素家族，是一种有效的血小板聚集抑制剂。

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