BTK(布鲁顿酪氨酸激酶)

BTK (Bruton's tyrosine kinase) binds PIP3 and phosphorylates phospholipase C, plays a crucial role in B cell maturation as well as mast cell activation.

Products for BTK

Cat.No. 产品名称 Information
GC32844 BMS-986195
BMS-986195
A covalent BTK inhibitor
GC32007 Btk inhibitor 2
BGB-3111 analog
Btk inhibitor 2 is a BTK inhibitor.
GC31760 BMS-935177 BMS-935177 is a potent, reversible Bruton's Tyrosine Kinase (BTK) inhibitor with an IC50 value of 2.8 nM and demonstrates good kinase selectivity. It is more potent against BTK than other kinase, including the other Tec family kinases (TEC, BMX, ITK, and TXK) over which the compound is between 5- and 67-fold selective.
GC31713 BMS-986142 A BTK inhibitor
GC31679 ARQ 531
MK-1026

Nemtabrutinib (ARQ 531, MK-1026) is an ATP-competitive tyrosine kinase inhibitor designed to target BTK with an IC50 of 0.85 nM. It also has a distinct kinase selectivity profile with strong inhibitory activity against several key oncogenic drivers from TEC, Trk and Src family kinases.
GC31339 PRN1008
PRN1008
PRN1008 (Rilzabrutinib) is a reversible covalent, selective and oral active inhibitor of Bruton’s Tyrosine Kinase (BTK), with an IC50 of 1.3 nM.
GC30155 PCI-33380
PCI-33380是布鲁顿酪氨酸激酶(BTK)的不可逆抑制剂(荧光探针)。
GC19333 BTK IN-1
SNS062 analog
A BTK inhibitor
GC19162 GDC-0853
GDC-0853
A BTK inhibitor
GC15453 ACP-196
阿卡替尼,ACP-196
A BTK inhibitor
GC13219 ONO-4059
GS-4059 analog
A derivative of ONO-4059
GC14857 LFM-A13 A BTK inhibitor
GC10924 Btk inhibitor 1 R enantiomer
伊布替尼中间体
Btk 抑制剂 1 R 对映异构体是依鲁替尼的杂质。 Btk 抑制剂 1 R 对映体可用于 Btk 抑制剂 1 R 对映体依鲁替尼二聚体和 Btk 抑制剂 1 R 对映体加合物的合成。 Ibrutinib 是一种选择性、不可逆的 Btk 抑制剂，IC50 为 0.5 nM。
GC12921 PCI-32765 Racemate
1-[3-[4-氨基-3-(4-苯氧基苯基)-1H-吡唑并[3,4-D]嘧啶-1-基]哌啶-1-基]丙-2-烯-1-酮,PCI-32765 Racemate
PCI-32765 Racemate (PCI-32765 Racemate) 是依鲁替尼的外消旋体。 Ibrutinib 是一种选择性的、不可逆的 Btk 抑制剂，IC50 值为 0.5 nM。
GC13439 CNX-774 A potent, selective, and irreversible BTK inhibitor
GC11995 GDC-0834 GDC-0834 是 GDC-0834 的 S-对映异构体。
GC11230 RN486 A selective BTK inhibitor
GC13365 CGI-1746
N-[3-[4,5-二氢-4-甲基-6-[[4-(4-吗啉基羰基)苯基]氨基]-5-氧代-2-吡嗪基]-2-甲基苯基]-4-(叔丁基)苯甲酰胺,CGI1746;CGI 1746
A potent, selective BTK inhibitor
GC11063 BMX-IN-1
N-[2-甲基-5-[9-[4-[(甲基磺酰基)氨基]苯基]-2-氧代苯并[H]-1,6-萘啶-1(2H)-基]苯基]-2-丙烯酰胺,BMX kinase inhibitor
A selective BMX and BTK inhibitor
GC13562 AVL-292
AVL292;AVL 292
A covalent BTK inhibitor
GC13812 PCI-32765 (Ibrutinib)
伊布替尼; PCI-32765
PCI-32765 (Ibrutinib) 是一种不可逆的选择性布鲁顿氏酪氨酸激酶 (BTK) 抑制剂，可选择性靶向其激酶结构域并通过降低其磷酸化能力来调节 BTK 下游信号传导，在无细胞试验中 IC50 为 0.5 nM 。