ADC Cytotoxin(ADC 细胞毒素)
ADC Cytotoxin are a large collection of toxins for antibody-drug conjugate (ADC) development projects. The toxins that can be used as payloads should be soluble, amenable to conjugation, and stable. There are myriads of cellular toxins in natural or synthesized, but only a few have been found adaptable for an ADC concept.
The toxins targeting tubulin filaments include Maytansinoids, Auristatins, Taxol derivatives, etc. Amatoxins are a class of transcription-inhibiting agents. They bind to RNA polymerase II, leading to cell apoptosis. Protein toxins function in the similar MOA (mechanism of action) with cellular toxins, they could inhibit protein synthesis and induce cell death. While enzyme-based ADCs alter the microenvironment of disease tissues to disturb their functions.
Products for ADC Cytotoxin
- Cat.No. 产品名称 Information
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GC34086
SJG-136 (NSC-694501)
NSC-694501
SJG-136 (NSC-694501) 是一种 DNA 交联剂,对于 pBR322 DNA 的 XL50 为 45 nM。 SJG-136 (NSC-694501) 具有有效的抗肿瘤活性。 - GC74118 SJG-136 intermediate-1 SJG-136 intermediate-1(化合物19)是合成SJG-136的中间体。
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GN10449
SN-38 (NK012)
7-乙基-10-羟基喜树碱,7-Ethyl-10-hydroxycamptothecin
A potent inhibitor of DNA topoisomerase I -
GC32753
Taltobulin (HTI-286)
N,BETA,BETA-三甲基-L-苯基丙氨酰基-N-[(1S,2E)-3-羧基-1-(1-甲基乙基)-2-丁烯基]-N,3-二甲基-L-缬氨酰胺,HTI-286; SPA-110
An inhibitor of microtubule polymerization -
GC61314
Taltobulin hydrochloride
HTI-286 hydrochloride; SPA-110 hydrochloride
Taltobulinhydrochloride(HTI-286hydrochloride)是一种合成的三肽半胱氨酸类似物,Taltobulin是一种有效的抗微管剂(antimicrotubule),可在体内外规避P-糖蛋白介导的耐药性。Taltobulinhydrochloride抑制纯化的微管蛋白聚合,破坏细胞中的微管组织,并诱导有丝分裂停滞以及凋亡(apoptosis)。 - GC34303 Taltobulin hydrochloride (HTI-286 hydrochloride) An inhibitor of microtubule polymerization
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GC74122
Taltobulin intermediate-4
(S,E) - 4 - ((S)-2 - ((叔丁氧基羰基)氨基)-N,3,3-三甲基丁酰胺基)-2
Taltobulin intermediate-4是Taltobulin合成中的中间体。 -
GC34135
Taltobulin trifluoroacetate (HTI-286 trifluoroacetate)
HTI-286 trifluoroacetate; SPA-110 trifluoroacetate
An inhibitor of microtubule polymerization - GC73154 TAM470 TAM470是一种新型的细胞溶解素,抑制微管聚合和微管解聚。
- GC74147 TAM558 intermediate-5 TAM558 intermediate-5是TAM558合成中的中间体。
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GC62288
Thailanstatin A
泰兰斯他汀A
Thailanstatin A 是一种有效的真核 RNA 剪接 (RNA splicing) 抑制剂 (IC50=650 nM)。Thailanstatin A 通过非共价结合到剪接体的 U2 snRNA 亚复合物的 SF3b 亚单位发挥作用,并且对多种癌细胞系显示低 nM 到亚 nM 的 IC50 值。Thailanstatin A 与 Trastuzumab 上的赖氨酸结合,可产生"无连接子 (linker-less)" ADC。 - GC70043 Tomaymycin DM Tomaymycin DM 是一种DNA烷化剂,是Tomaymycin 的一个衍生物,是PBD的一个单体,能够作为肿瘤靶向抗体偶联活性分子 ADCs 的有效载荷。
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GC33155
Tubulysin A (TubA)
N-(2-氨基-2-氧代乙基)-N-(羧甲基)甘氨酸,TubA
Tubulysin A (TubA)(TubA) 是一种粘细菌产品,可在许多体外试验中用作抗血管生成剂;抗微管、抗有丝分裂、凋亡诱导剂、抗癌、抗血管生成和抗增殖。 -
GC16277
α-Amanitin
alpha-鹅膏覃碱; α-Amatoxin
A selective RNA polymerase II inhibitor