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Home >> Signaling Pathways >> Apoptosis >> Apoptosis Inducers

Apoptosis Inducers(细胞凋亡诱导剂)

Apoptosis, a programmed cell death to eliminate damaged or abnormal cells, is a highly organized physiological process characterized by condensation of nuclear heterochromatin, cell shrinkage and loss of positional organization of organelles in the cytoplasm. Apoptosis inducers are a collection of compounds that are capable of inducing apoptosis in cells. Apoptosis has been extensively studied in numerous researches, where induction of apoptosis has been associated with a variety of events, including activation of p53 gene, transcription factor NF-κB or caspases. Apoptosis inducers have the potential to be incorporated into the management and therapy or prevention of cancer for their ability to induce apoptosis in cancer cells.

Products for  Apoptosis Inducers

  1. Cat.No. 产品名称 Information
  2. GC16037 7BIO

    7-Bromoindirubin-3’-oxime

     A caspase-independent (nonapoptotic) cell death inducer
  3. GC14791 F16 A potential antitumor agent
  4. GC13034 ML-291 An activator of apoptosis through UPR
  5. GC14847 Psoralidin

    补骨脂定

     A furanocoumarin with anti-cancer activity
  6. GC16375 (±)-Jasmonic Acid methyl ester

    甲基茉莉酮酸酯,(±)-Methyl Jasmonate

     A plant growth regulator
  7. GC11988 15-acetoxy Scirpenol

    15-乙酰蛇形菌素

     A trichothecene mycotoxin
  8. GC10661 Destruxin B

    黑僵菌素 B

     An insecticidal mycotoxin
  9. GC16661 Citrinin

    桔霉素; NSC 186

     Citrinin是一种具有多种生物活性的霉菌毒素，由青霉属、曲霉属和红曲霉属的几种真菌菌株产生。
  10. GC14050 MPI-0441138

    EP128265

     A potent inducer of apoptosis and growth inhibition
  11. GC11834 Epibrassinolide

    表油菜素内酯; 24-Epibrassinolide; B1105; BP55

     A brassinosteroid with protective effects
  12. GC15036 Raltegravir potassium salt

    雷特格韦钾盐; MK 0518 potassium

     An HIV-1 integrase inhibitor
  13. GC11710 CFM 4 CFM 4 是 CARP-1/APC-2 结合的有效小分子拮抗剂。 CFM 4 阻止 CARP-1 与 APC-2 结合，导致 G2M 细胞周期停滞，并诱导细胞凋亡，IC50 范围为 10-15 μM. CFM 4 还抑制耐药人类乳腺癌细胞的生长。
  14. GC15035 PM00104

    Potent antimyeloma agent
  15. GC14312 Meisoindigo

    甲异靛; Dian III; N-Methylisoindigotin; Natura-α

     An anticancer agent
  16. GC10744 Bendamustine HCl

    盐酸苯达莫司汀; SDX-105

     A DNA alkylating agent
  17. GC17198 Cycloheximide

    Naramycin A; Actidione; 3-[2-(3,5-Dimethyl-2-oxocyclohexyl)-2-hydroxyethyl]glutarimide

     环己酰亚胺是一种抗生素，它在翻译水平上抑制蛋白质合成，仅对真核细胞的细胞质（80s）核糖体起作用。
  18. GC15503 NSC 687852 (b-AP15)

    b-AP15

     An inhibitor of the deubiquitinases USP14 and UCHL5
  19. GC12353 Mitomycin C

    丝裂霉素 C,Ametycine

     Mitomycin C是一种抗生素，从链霉菌（Streptomyces Caespitosus）或淡紫色链霉菌（Streptomyces Lavendulae）中分离出来。
  20. GC17131 Streptozocin

    链脲佐菌素; Streptozotocin; U 9889

     Streptozocin 是一种有效的 DNA 甲基化抗生素，是一种天然存在的亚硝基酰胺，在实验模型中广泛用于产生糖尿病。
  21. GC10315 Plumbagin

    白花丹素; 2-Methyljuglone

     A natural naphthoquinone
  22. GC10282 Piperlongumine

    荜茇酰胺; Piplartine

     Piperlongumine是从Piper longum L.中提取的天然生物碱化合物，具有多种药理活性，包括抗肿瘤、脂质代谢调节、抗血小板聚集和镇痛活性等。
  23. GC14860 Oncrasin 1

    1-(4-氯苄基)-1H-吲哚-3-甲醛

     An anticancer agent
  24. GC15484 Deguelin

    鱼藤素; (-)-Deguelin; (-)-cis-Deguelin

     A potent antiproliferative rotenoid compound
  25. GC17969 CHM 1

    NSC656158

     An inhibitor of tubulin polymerization
  26. GC16866 Actinomycin D

    放线菌素D,DACTINOMYCIN

     阿克替诺霉素D（也称为达克替诺霉素）是一种从链霉菌属中分离出来的天然色胺肽，含有一个杂环色团和两个五元环戊肽内酯环。
  27. GC12258 2,3-DCPE hydrochloride 2,3-DCPE 是一种促凋亡化合物，对癌细胞\u003cem\u003e相对于\u003c/em\u003e正常人细胞具有选择性
  28. GC18044 Trabectedin

    曲贝替定; Ecteinascidin 743; ET-743

     An alkaloid with anticancer activity
  29. GC16055 SMIP004

    N-(4-丁基-2-甲基苯基)乙酰胺,SMIP 004;SMIP-004

     SMIP004 是一种 SKP2 E3 连接酶抑制剂，可下调 SKP2 并稳定 p27。 SMIP004 是人前列腺癌细胞的癌细胞选择性凋亡诱导剂。
  30. GC12857 R1530

    5-(2-氯苯基)-7-氟-1,2-二氢-8-甲氧基-3-甲基吡唑并[3,4-B][1,4]苯并二氮杂卓,R 1530;R-1530

     A multi-kinase inhibitor
  31. GC17874 Matrine

    苦参碱; Matridin-15-one; Vegard; α-Matrine

     苦参碱（Matrine）是一种存在于槐属植物中的生物碱，可作为 kappa 阿片受体和µ-受体激动剂。
  32. GC12139 Gambogic Acid

    藤黄酸; Beta-Guttiferrin

     Gambogic Acid 是一种细胞渗透性 caspase 激活剂和细胞凋亡诱导剂，常用于乳腺癌、肺癌和肝癌等的研究。
  33. GC14787 Curcumin

    姜黄素; Diferuloylmethane; Natural Yellow 3; Turmeric yellow

     A yellow pigment with diverse biological activities
  34. GC16116 Costunolide

    木香烃内酯; (+)-Costunolide; Costus lactone

     A natural sesquiterpene lactone
  35. GC14065 Capsaicin

    辣椒素; (E)-Capsaicin

     辣椒素是一种高度选择性的瞬时受体电位阳离子通道激动剂，亚家族 V，成员 1 (TRPV1)，一种配体门控的非选择性阳离子通道，优先在小直径感觉神经元上表达 < /sup>。
  36. GC11632 Brassinolide

    油菜素内酯; Brassin lactone

     A plant growth regulator
  37. GC10480 Betulinic acid

    白桦脂酸; Lupatic acid; Betulic acid

     白桦脂酸（Betulinic acid）是一种天然的五环三萜类化合物，是真核细胞拓扑异构酶I的抑制剂，IC50值为5μM。
  38. GC12053 BAM7

    BAM 7;BAM-7

     A direct activator of Bax
  39. GC12791 3,3'-Diindolylmethane

    3,3'-二吲哚甲烷,diindolylmethane, 3,3'-Methylenediindole,DIM,Arundine,HB236

     A phytochemical with antiradiation and chemopreventative effects
  40. GC12649 TW-37

    N-[4-(2-叔丁基苯磺酰基)苯基]-2,3,4-三羟基-5-(2-异丙基苯基甲基)苯甲酰胺,TW37,TW 37

     An inhibitor of the Bcl-2 family proteins
  41. GC15084 2-Methoxyestradiol (2-MeOE2)

    二甲氧基雌二醇; 2-ME2; NSC-659853

     2-Methoxyestradiol (2-MeOE2/2-Me)是一种HIF-1α抑制剂。
  42. GN10421 Kaempferol

    山奈酚,Kempferol

     Kaempferol是一种黄酮类化合物，可作为ERRα和ERRγ的反向激动剂，具有抗氧化、抗炎和抗肿瘤活性。
  43. GC15878 Atractyloside Dipotassium Salt

    苍术苷钾盐

     Inhibitor of ADP/ATP translocases
  44. GC12961 Apicidin

    OSI 2040

    A cell-permeable HDAC inhibitor

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