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Home >> Signaling Pathways >> Apoptosis >> Bcl-2 Family

Bcl-2 Family(Bcl-2蛋白家族)

Bcl-2 family proteins are a group of proteins homologous to the Bcl-2 protein and characterized by containing at least one of four conserved Bcl-2 homology (BH) domains (BH1, BH2, BH3 and BH4). Bcl-2 family proteins, consisting of pro-apoptotic and anti-apoptotic molecules, can be classified into the following three subfamilies according to sequence homology within four BH domains: (1) a subfamily shares sequence homology within all four BH domains, such as Bcl-2, Bcl-XL and Bcl-w which are anti-apoptotic; (2) a subfamily shares sequence homology within BH1, BH2 and BH4, such as Bax and Bak which are pro-apoptotic; (3) a subfamily shares sequence homology only within BH3, such as Bik and Bid which are pro-apoptotic.

Products for  Bcl-2 Family

  1. Cat.No. 产品名称 Information
  2. GC36558 Mcl1-IN-12 Mcl1-IN-12 (Compound F) 是一种选择性的 Mcl-1 抑制剂，对 Bcl-2 的作用较弱，Ki 值分别为 0.29 和 3.1 μM。
  3. GC36557 Mcl1-IN-11 Mcl1-IN-11 (Compound G) 是一种选择性的 Mcl-1 抑制剂，对 Bcl-2 的作用较弱，Ki 值分别为 0.06 和 4.2 μM。
  4. GC36556 Mcl1-IN-1

    2-[2-[(5-氯-8-羟基-7-喹啉基)(2-吡啶基氨基)甲基]苯氧基]乙酸

     Mcl1-IN-1 是一种骨髓细胞因子 1 (Mcl-1) 抑制剂，IC50 为 2.4 ?M。
  5. GC35882 dMCL1-2 dMCL1-2 是一种基于 PROTAC 技术的，高效、选择性的 MCL1 降解剂，结合 MCL1 的 KD 值为 30 nM。dMCL1-2 通过降解 MCL1 激活细胞凋亡。
  6. GC35001 (S)-Gossypol acetic acid

    (S)-(+)-Gossypol acetic acid

     (S)-Gossypol acetic acid 是天然产物 Gossypol 的异构体。(S)-Gossypol 以高亲和力结合到 Bcl-xL 和 Bcl-2 蛋白的 BH3 结合沟。
  7. GC34980 (E)-Ferulic acid

    反式阿魏酸,(E)-Coniferic acid

     Trans-ferulic acid is a potent activator of AMPKunder high glucose condition.
  8. GC34389 PUMA BH3 PUMABH3是一种p53正向凋亡调控因子(PUMA)BH3结构域多肽，作为Bak的直接激活剂，Kd值为26nM。
  9. GC34263 Bak BH3 BakBH3是一种多肽，源于Bak蛋白的BH3结构域，在细胞中，能够抑制Bcl-xL的活性。
  10. GC34134 Glycocholic acid

    甘氨胆酸

     Glycocholic acid是一种参与脂肪乳化的结晶胆汁酸，是胆酸与甘氨酸的结合物，它以钠盐的形式存在于哺乳动物的胆汁中。
  11. GC34096 (R)-(-)-Gossypol acetic acid (AT-101 (acetic acid))

    (R)-(-)-醋酸棉酚; AT-101 (acetic acid); (-)-Gossypol acetic acid; (R)-Gossypol acetic acid

     (R)-(-)-Gossypol (AT-101) acetic acid, the R-(-) enantiomer of Gossypol acetic acid, binds with Bcl-2, Bcl-xL and Mcl-1 with Ki of 0.32 μM, 0.48 μM and 0.18 μM in cell-free assays; does not inhibit BIR3 domain and BID. AT-101 simultaneously triggers apoptosis and a cytoprotective type of autophagy. Phase 2.
  12. GC33407 BM 957 BM957是Bcl-2和Bcl-xL的有效抑制剂，其Ki值分别为1.2，<1nM，IC50值分别为5.4，6.0nM。
  13. GC33401 S55746 hydrochloride (BLC201 (hydrochloride))

    BCL201 hydrochloride

     S55746 hydrochloride (BLC201 (hydrochloride)) (BCL201 hydrochloride) 是一种有效的，具有口服活性的选择性 BCL-2 抑制剂，Ki 为 1.3 nM，Kd 为 3.9 nM。 S55746 hydrochloride (BLC201 (hydrochloride)) (BCL201 hydrochloride) 具有低毒的抗肿瘤活性。
  14. GC33364 Mcl1-IN-4 Mcl1-IN-4是Mcl1的抑制剂，IC50值为0.2μM。
  15. GC33347 Mcl1-IN-3 Mcl1-IN-3是Mcl1的抑制剂,来自专利专利WO2015153959A2，化合物实例57；IC50和Ki值分别为0.67和0.13μM。
  16. GC33312 ML311 An Mcl-1 inhibitor
  17. GC33295 MIK665 (S-64315)

    S-64315

     An Mcl-1 inhibitor
  18. GC33283 AZD-5991 Racemate AZD5991 is a macrocyclic MCL-1 inhibitor with sub-nanomolar affinity for MCL-1 (Ki = 0.13 nM). The binding affinity of AZD5991 is about 25-fold lower for mouse Mcl-1 vs. human Mcl-1 but only four-fold lower for rat Mcl-1.
  19. GC33255 AZD4320 AZD4320是BH-3的新型类似物，有效的BCL2/BCLxL的双重抑制剂。AZD4320对于KPUM-MS3，KPUM-UH1，和STR-428细胞系的IC50分别为26nM，17nM，和170nM。
  20. GC33247 AZD-5991 An Mcl-1 inhibitor
  21. GC33239 AZD-5991 S-enantiomer AZD-5991S-enantiomer是AZD-5991的低活性S型对映体。AZD-5991S-enantiomer是一种Mcl-1抑制剂，FRET实验检测的IC50为6.3μM，SPR实验检测的Kd为0.98μM。
  22. GC33052 VU0661013 VU661013 is a novel, potent, selective MCL1 inhibitor with Ki of 97 ± 30 pM of human MCL-1 in a TR-FRET assay. However, VU661013 does not significantly inhibit BCL-xL or BCL-2 with Ki > 40 μM or = 0.73 μM. VU661013 de-stabilizes BIM/MCL-1 association, leads to apoptosis in AML.
  23. GC33035 Mcl1-IN-2

    7-[(2-吡啶基氨基)-2-噻吩基甲基]-8-喹啉醇

    Mcl1-IN-2 是骨髓细胞因子 1 (Mcl-1) 的抑制剂。 Mcl1-IN-2 是一种非竞争性的德里 metallo-β-lactamase (NDM-1) 抑制剂。
  24. GC32998 Ginsenoside Rh4

    人参皂苷RH4

     Ginsenoside Rh4 is an important active ingredient of traditional Chinese medicine ginseng, which has been shown to inhibit Wnt/β-Catenin, JAK2/STAT3, TGF-β/Smad2/3 and other signaling pathways.
  25. GC32981 A-385358 A-385358是Bcl-XL的一个选择性抑制剂，对于Bcl-XL和Bcl-2的Ki值分别为0.80和67nM。
  26. GC32947 S55746 (BLC201)

    BCL201

     S55746 (S 055746,BCL201) is a novel, orally active BCL-2 specific inhibitor (Ki = 1.3 nM) with poor affinity for BCL-XL and no significant binding to MCL-1, BFL-1 (BCL2A1/A1). The selectivity of S55746 for BCL-2 versus BCL-XL ranges from ~70 to 400 folds.
  27. GC31806 Bz 423 (BZ48)

    BZ48

     Bz 423 (BZ48) 是一种促凋亡的 1,4-苯二氮卓类药物，在狼疮小鼠模型中具有治疗特性，显示出对自身反应性淋巴细胞的选择性，并激活 Bax 和 Bak。
  28. GC19452 AMG-176

    AMG-176

     AMG-176 (Tapotoclax) 是一种有效的、选择性的、具有口服活性的 MCL-1 抑制剂，Ki 为 0.13 nM。
  29. GC10661 Destruxin B

    黑僵菌素 B

     An insecticidal mycotoxin
  30. GC17513 A-1331852 A Bcl-xL inhibitor
  31. GC17512 A-1155463

    醋酸艾塞那肽

     A Bcl-xL inhibitor
  32. GC18136 BH3I-1

    BHI1; BH 3I1

     An inhibitor of anti-apoptotic Bcl-2 proteins
  33. GC12621 S63845 An Mcl-1 inhibitor
  34. GC16278 A-1210477 A selective Mcl-1 inhibitor
  35. GC10721 BDA-366

    1-[[(2S)-3-(二乙基氨基)-2-羟基丙基]氨基]-4-[[(2S)-2-环氧乙烷基甲基]氨基]-9,10-蒽醌

     A Bcl2-BH4 domain antagonist
  36. GC11140 Radotinib(IY-5511)

    拉多替尼

     A selective Bcr-Abl tyrosine kinase inhibitor
  37. GC17008 (+)-Apogossypol

    變棉子酚,Apogossypol; NSC736630

    (+)-Apogossypol 是一种泛 BCL-2 拮抗剂。 (+)-Apogossypol 与 Mcl-1、Bcl-2 和 Bcl-xL 结合，EC50 分别为 2.6、2.8 和 3.69 μM。
  38. GC12902 Pyridoclax

    MR-29072

     Pyridoclax 是一种潜在的 Mcl-1 抑制剂。
  39. GC15805 UMI-77 A selective Mcl-1 inhibitor
  40. GC10567 TCPOBOP An agonist for mouse CAR
  41. GC15480 Marinopyrrole A

    Marinopyrrole A

     An alkaloid with antibacterial activity
  42. GC13317 WEHI-539 hydrochloride A selective Bcl-xL inhibitor
  43. GC16938 Muristerone A

    米乐甾酮A

     An ecdysteroid receptor agonist
  44. GC15400 MIM1

    4-[[[2-(环己基亚氨基)-4-甲基-3(2H)-噻唑基]亚氨基]甲基]-1,2,3-苯三醇,Inhibitor of Mcl-1

     An Mcl-1 inhibiting molecule
  45. GC12046 iMAC2 iMAC2 是一种有效的 MAC 抑制剂，IC50 为 28 nM，LD50 为 15000 nM。
  46. GC15987 BIM, Biotinylated

    Bim peptide fragment with a biotin moiety attached
  47. GC16695 Bax inhibitor peptide, negative control Peptide inhibit Bax translocation to mitochondria
  48. GC17195 Bax inhibitor peptide V5

    BIP-V5; BAX Inhibiting Peptide V5

     A Bax inhibitor
  49. GC16023 Bax inhibitor peptide P5 Bax inhibitor
  50. GC12763 Bax channel blocker Bax 通道阻滞剂是 BAX（一种凋亡调节剂）的选择性变构抑制剂。 Bax 通道阻滞剂直接与 BAX 结合并变构抑制 BAX 活化。 Bax 通道阻滞剂具有研究由 BAX 依赖性细胞死亡介导的疾病的潜力。
  51. GC12258 2,3-DCPE hydrochloride 2,3-DCPE 是一种促凋亡化合物，对癌细胞\u003cem\u003e相对于\u003c/em\u003e正常人细胞具有选择性

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