Bcl-2 Family(Bcl-2蛋白家族)

Bcl-2 family proteins are a group of proteins homologous to the Bcl-2 protein and characterized by containing at least one of four conserved Bcl-2 homology (BH) domains (BH1, BH2, BH3 and BH4). Bcl-2 family proteins, consisting of pro-apoptotic and anti-apoptotic molecules, can be classified into the following three subfamilies according to sequence homology within four BH domains: (1) a subfamily shares sequence homology within all four BH domains, such as Bcl-2, Bcl-XL and Bcl-w which are anti-apoptotic; (2) a subfamily shares sequence homology within BH1, BH2 and BH4, such as Bax and Bak which are pro-apoptotic; (3) a subfamily shares sequence homology only within BH3, such as Bik and Bid which are pro-apoptotic.

Products for Bcl-2 Family

Cat.No. 产品名称 Information
GC11921 WEHI-539
WEHI539,WEHI 539
A selective Bcl-xL inhibitor
GC12139 Gambogic Acid
藤黄酸; Beta-Guttiferrin
Gambogic Acid 是一种细胞渗透性 caspase 激活剂和细胞凋亡诱导剂，常用于乳腺癌、肺癌和肝癌等的研究。
GC13065 Chelerythrine Chloride
盐酸白屈菜红碱
Potent inhibitor of PKC and Bcl-xL
GC12053 BAM7
BAM 7;BAM-7
A direct activator of Bax
GC11106 AT-101
(-)-棉子素,(R)-(-)-Gossypol;R-(-)-gossypol acetic acid;AT 101;AT101
AT-101 (AT-101) 是天然产物棉酚的左旋异构体。 AT-101 与 Bcl-2、Mcl-1 和 Bcl-xL 蛋白结合，Kis 分别为 260±30 nM、170±10 nM 和 480±40 nM。
GC10153 Sabutoclax
BI-97C1
A pan-Bcl-2 inhibitor
GC14080 Apogossypolone (ApoG2)
ApoG2
Apogossypolone (ApoG2) (ApoG2) 是一种具有口服活性的 Bcl-2 家族蛋白抑制剂，对 Bcl-2、Mcl-1 和 Bcl-XL 的 Ki 值分别为 35、25 和 660 nM。
GC11569 Obatoclax mesylate (GX15-070)
Obatoclax甲磺酸盐,GX15-070 Mesylate
An antagonist of pro-survival Bcl-2 proteins
GC13498 BM-1074 BM-1074 是一种有效且特异性的 Bcl-2/Bcl-xL 抑制剂，对 Bcl-2 和 Bcl-xL 的 Ki 值 < 1 nM，IC50 值分别为 1.8 nM 和 6.9 nM。 BM-1074 诱导细胞凋亡，并对四种小细胞肺癌细胞系（H146、H1963、H187 和 H1417）具有抗增殖活性，IC50 值为 1-2 nM。
GC12649 TW-37
N-[4-(2-叔丁基苯磺酰基)苯基]-2,3,4-三羟基-5-(2-异丙基苯基甲基)苯甲酰胺,TW37,TW 37
An inhibitor of the Bcl-2 family proteins
GC12405 ABT-263 (Navitoclax)
Navitoclax,ABT-263,ABT263,ABT 263
ABT-263 (Navitoclax) 是 Bcl-xL、Bcl-2 和 Bcl-w 的抑制剂，Ki 分别≤0.5 nM、≤1 nM 和≤1 nM。
GC17234 ABT-737
ABT 737, ABT737
An inhibitor of anti-apoptotic Bcl-2 proteins
GC14069 ABT-199
维奈妥拉; ABT-199; GDC-0199; Venetoclax
Venetoclax (ABT-199, GDC-0199) 是 Bcl-2 的选择性抑制剂，在无细胞试验中 K i 为 0.01 nM。
GN10082 Gossypol
棉酚; BL 193
A natural polyphenol with diverse effects
GN10341 Acetate gossypol
醋酸棉酚; (±)-Gossypol-acetic acid; BL-193 (acetic acid)
棉酚乙酸 ((±)-Gossypol-乙酸) 与 Bcl-xL 蛋白和 Bcl-2 蛋白结合，Kis 分别为 0.5-0.6 μM 和 0.2-0.3 mM。
GN10645 Jaceosidin
棕矢车菊素
A natural methylated trihydroxyflavone
GN10040 Dehydrocorydaline
脱氢紫堇碱; 13-Methylpalmatine
An alkaloid with diverse biological activities
GN10219 Ciwujianoside-B
刺五加皂苷 B
Ciwujianoside-B 是从刺五加叶中分离得到的，口服后能在大脑中渗透和发挥作用。
GN10463 Chelerythrine
白屈菜红碱
Chelerythrine 是一种天然生物碱，是一种有效的选择性 Ca2+/磷脂依赖性 PKC 拮抗剂，IC50 为 0.7 μM。
GC11510 HA14-1
乙基-2-氨基-6-溴-4-(1-氰基-2-乙氧基-2-甲酰)-4H-苯并呋喃-3-羧酸
A Bcl-2 inhibitor