Other Apoptosis(其他细胞凋亡)

Cat.No. 产品名称 Information

GC40861 Pinosylvin

赤松素

A stilbene with diverse biological activities

GC40698 (-)-Perillyl Alcohol

紫苏醇

A monoterpene alcohol with diverse biological activities

GC40673 Geranyl Acetate

乙酸香叶酯

A monoterpene with diverse biological activities

GC40669 Nerol

橙花醇

A monoterpene

GC40483 Patulin

棒曲霉素; Terinin

A mycotoxin

GC19541 (rac)-Antineoplaston A10

3-苯基乙酰氨基-2,6-哌啶二酮

(rac)-Antineoplaston A10 是 Antineoplaston A10 的外消旋体。 Antineoplaston A10 是一种潜在的 Ras 抑制剂，可用于治疗神经胶质瘤、淋巴瘤、星形细胞瘤和乳腺癌。

GC34862 WYC-209

4,5-二(羟甲基)-2-苯基-1H-咪唑

WYC-209是一种合成类视黄醇，能抑制恶性小鼠黑色素瘤肿瘤再生细胞(TRC)的增殖，IC50值为0.19μM。WYC-209主要细胞靶点是维甲酸受体(RARs)。

GC34831 Tauroursodeoxycholate dihydrate

牛磺熊去氧胆酸二水合物; Tauroursodeoxycholic acid dihydrate; TUDCA dihydrate; UR 906 dihydrate

Tauroursodeoxycholatedihydrate(TUDCAdihydrate;UR906dihydrate;Taurolitedihydrate)是一种内质网应激抑制剂。Tauroursodeoxycholate显著降低凋亡分子如caspase-3和caspase-12表达。Tauroursodeoxycholate也抑制ERK。

GC34634 JG-98

3-苄基-2-((Z)-((E)-5-(6-氯-3-甲基苯并[D]噻唑-2(3H)-亚基)-3-乙基-4-氧代噻唑啉-2-亚基)甲基)噻唑-3-鎓氯化物

JG-98 is an allosteric inhibitor of Hsp70 that binds tightly to a deep pocket that is conserved in members of the Hsp70 family. JG-98 induces classical apoptosis features, including morphological changes consistent with programmed cell death and positive annexin staining. JG-98 exhibits anticancer activity.

GC34543 cRIPGBM cRIPGBM是RIPGBM的促凋亡衍生物，是通过与受体相互作用蛋白激酶2(RIPK2)结合，诱导GBM肿瘤干细胞凋亡的选择性诱导剂，对GBM-1细胞的EC50值为68nM。

GC34511 BTR-1 BTR-1 induces cytotoxicity in a time- and concentration-dependent manner on leukemia cell line CEM. BTR-1 affects DNA replication by inducing a block at S phase and leads to activation of apoptosis to induce cell death.

GC10150 Necrosulfonamide

N-[4-[[(3-甲氧基吡嗪基)氨基]磺酰基]苯基]-3-(5-硝基-2-噻吩基)-2-丙烯酰胺

Necrosulfonamide(NSA)是MLKL(混合系激酶域样蛋白)的一种特异性抑制剂。

GC34303 Taltobulin hydrochloride (HTI-286 hydrochloride) An inhibitor of microtubule polymerization

GC34181 Tauroursodeoxycholate (TUDCA)

牛磺熊去氧胆酸; Tauroursodeoxycholic acid; TUDCA; UR 906

牛磺酸脱氧胆酸盐(TUDCA)是包括肝细胞在内的多种细胞的细胞保护剂,也是癌症细胞凋亡的诱导剂。

GC34177 Sesamol

芝麻酚

A lignan with diverse biological activities

GC34157 Desacetylcinobufotalin (Deacetylcinobufotalin)

去乙酰华蟾蜍它灵,Deacetylcinobufotalin

Desacetylcinbufotalin (Deacetylcinbufotalin) 是一种天然化合物；凋亡诱导剂，对HepG2细胞有明显抑制作用，IC50值为0.0279μ；mol/ml。

GC34125 (E)-[6]-Dehydroparadol (E)-[6]-Dehydroparadol来自专利US9272994化合物M15,能够抑制人体癌细胞生长并且诱导细胞凋亡。在HCT-116和H-1299细胞中的IC50值分别为43.02和41.59μM。

GC34095 ONC212 A GPR132 agonist

GC34092 Glycochenodeoxycholic acid (Chenodeoxycholylglycine)

甘氨鹅脱氧胆酸; Chenodeoxycholylglycine

A quantitative analytical standard guaranteed to meet MaxSpec^? identity, purity, stability, and concentration specifications

GC34057 TBHQ (tert-Butylhydroquinone)

特丁基对苯二酚; tert-Butylhydroquinone

TBHQ(tert-Butylhydroquinone)是一种强效的酚类抗氧化剂，能够减轻氧化应激和炎症反应。

GC34021 Vitamin K4 (acetomenaphthone)

维生素K4; acetomenaphthone

A synthetic form of vitamin K

GC33831 Lidocaine hydrochloride (Lignocaine hydrochloride)

盐酸利多卡因; Lignocaine hydrochloride

An Analytical Reference Standard

GC33825 Taurochenodeoxycholic acid (12-Deoxycholyltaurine)

牛磺鹅去氧胆酸; 12-Deoxycholyltaurine

A quantitative analytical standard guaranteed to meet MaxSpec identity, purity, stability, and concentration specifications

GC33779 Cysteamine (β-Mercaptoethylamine)

巯基乙胺

2-Aminoethanethiol (cysteamine, β-Mercaptoethylamine, 2-Mercaptoethylamine, Thioethanolamine, Mercaptamine) is a radiation-protective agent that oxidizes in air to form cystamine.

GC33501 Bornyl acetate

(-)-乙酸龙脑酯; L-(-)-Bornyl acetate

An acetate form of borneol

GC19485 DC661 A PPT1 inhibitor

GC33291 Tubulin inhibitor 1 Tubulininhibitor1是tubulin抑制剂，靶作用于秋水仙素结合位点，抑制微管蛋白聚集。Tubulininhibitor1具有抗肿瘤活性，能够导致细胞G2/M期有丝分裂停滞，诱导细胞凋亡。

GC33218 CA-5f CA-5f 是一种有效的晚期巨自噬/自噬抑制剂，通过抑制自噬体-溶酶体融合。 CA-5f 增加 LC3B-II（一种监测自噬的标志物）和 SQSTM1 蛋白，并且还增加 ROS 的产生。抗肿瘤活性。

GC33189 SAR125844 SAR125844 is a potent intravenously active and highly selective Met (c-Met) kinase inhibitor, displaying nanomolar activity against the wild-type kinase (IC50 value of 4.2 nmol/L) and H1094Y, Y1235D, M1250T, L1195V, and D1228H kinase domain mutants (IC50 values of 0.22, 1.7, 6.5, 65, and 81 nmol/L, respectively).

GC33167 Rhosin An inhibitor of the Rho-GEF protein-protein interaction

GC33156 Ecteinascidin 770 (Ecteinascidine 770)

Ecteinascidine 770; Et-770

Ecteinascidin 770 (Ecteinascidin 770) (ET-770) 是一种 1,2,3,4-四氢异喹啉生物碱，具有有效的抗癌活性；抑制 U373MG 细胞，IC50 为 4.83 nM。

GC33155 Tubulysin A (TubA)

N-(2-氨基-2-氧代乙基)-N-(羧甲基)甘氨酸,TubA

Tubulysin A (TubA)(TubA) 是一种粘细菌产品，可在许多体外试验中用作抗血管生成剂；抗微管、抗有丝分裂、凋亡诱导剂、抗癌、抗血管生成和抗增殖。

GC33143 Podocarpusflavone A

竹柏双黄酮 A；罗汉松双黄酮A

A biflavone with diverse biological activities

GC33074 SSE15206 SSE15206是一种微管(microtubule)聚合抑制剂，其在HCT116细胞SRB增殖实验中的GI50值为197nM。

GC33043 EL-102 EL102是HIF1α的抑制剂，能够抑制微管蛋白聚合和减少它的稳定性。

GC33029 Forodesine (BCX-1777 freebase)

呋咯地辛; BCX-1777; Immucillin-H

A nucleoside analog and PNP inhibitor

GC33002 PBOX 6 PBOX6是一种pyrrolo-1,5-benzoxazepine(PBOX)化合物，可作为微管解聚剂和促凋亡剂起作用。

GC32998 Ginsenoside Rh4

人参皂苷RH4

Ginsenoside Rh4 is an important active ingredient of traditional Chinese medicine ginseng, which has been shown to inhibit Wnt/β-Catenin, JAK2/STAT3, TGF-β/Smad2/3 and other signaling pathways.

GC32997 Cinchonine ((8R,9S)-Cinchonine)

辛可宁; (8R,9S)-Cinchonine; LA40221

Cinchonine (LA40221) is an alkaloid and a stereoisomer and pseudo-enantiomer of cinchonidine.

GC32973 SID 3712249 (MiR-544 Inhibitor 1)

MiR-544 Inhibitor 1

An inhibitor of miR-544 biogenesis

GC32929 MIR96-IN-1 MIR96-IN-1选择性抑制微小RNA-96的生物合成,上调蛋白靶点(FOXO1)且诱导癌细胞凋亡。

GC32901 ROC-325 An autophagy inhibitor

GC32895 Maytansinol (Ansamitocin P-0)

美登醇,Ansamitocin P-0

An ansa macrolide

GC32853 PD0166285

6-(2,6-二氯苯基)-2-[[4-[2-(二乙基氨基)乙氧基]苯基]氨基]-8-甲基吡啶并[2,3-D]嘧啶-7(8H)-酮

PD0166285 is a potent Wee1 and Chk1 inhibitor with activity at nanomolar concentrations (IC50=24 nM for Wee1 and 72 nM for Myt1). PD0166285 is also a novel G2 checkpoint abrogator. PD0166285 induces apoptosis.

GC32841 Catechin ((+)-Catechin)

儿茶素; (+)-Catechin; Cianidanol; Catechuic acid

(+)-Catechin (Cianidanol, Catechinic acid, Catechuic acid) is an antioxidant flavonoid, occurring especially in woody plants as both (+)-catechin and (-)-epicatechin (cis) forms.