Other Apoptosis(其他细胞凋亡)

Cat.No. 产品名称 Information

GC32724 LW6 (HIF-1α inhibitor)

HIF-1α inhibitor; LW8

LW6是一种缺氧诱导因子1(hypoxia inducing factor 1, HIF)抑制剂,通过降解HIF-1α有效抑制HIF-1α的积累,但不影响缺氧时HIF- 1a mRNA水平。

GC32719 dBET6 A PROTAC that drives BRD4 degradation

GC32710 GDC-0077 (RG6114)

GDC-0077; RG6114

Inavolisib (GDC-0077, RG6114, RO-7113755) is a potent selective inhibitor of PI3K alpha (PI3Kα) with an IC50 of 0.038 nM. GDC-0077 is >300-fold more selective for PI3K alpha over the other class I PI3K isoforms (beta, delta, and gamma) and >2000-fold more selective over PIK family members. GDC-0077 binds to the ATP binding site of PI3K and inhibits the phosphorylation of PIP2 to PIP3.

GC32708 Forodesine hydrochloride (BCX-1777)

BCX-1777 hydrochloride; Immucillin-H hydrochloride

A nucleoside analog and PNP inhibitor

GC32692 APTO-253 (LOR-253)

LOR-253; LT-253

APTO-253 是一种新型小分子，通过诱导 Kruppel 样因子 4 (KLF4) 主转录因子基因表达，从而抑制细胞周期并导致程序性细胞死亡，发挥强大的抗肿瘤活性。

GC32687 Takinib

EDHS-206

A TAK1 inhibitor

GC32681 GSK2795039 A NOX2 inhibitor

GC32587 Clofilium tosylate

氯非铵甲苯磺酸盐

Clofiliumtosylate是一种钾通道(potassiumchannel)阻滞剂，作用于人早幼粒细胞白血病(HL-60)细胞，激活caspase-3而诱导凋亡。具有抗心律失常作用。

GC32391 Pyrogallol

邻苯三酚

A natural oxidant

GC32138 Furazolidone

呋喃唑酮

A nitrofuran antiprotozoal and antibacterial agent

GC32127 Alofanib (RPT835)

RPT835

An allosteric inhibitor of FGFR2

GC32066 RRx-001

ABDNAZ

RRx-001 是一种源自航空航天的抗癌剂，具有产生活性氮物质 (RNS) 的化学作用，可导致表观遗传改变，例如癌细胞中的 DNA 甲基化和组蛋白乙酰化。

GC31783 Methyl 3,4-dihydroxybenzoate (Protocatechuic acid methyl ester)

3,4-二羟基苯甲酸甲酯,Protocatechuic acid methyl ester; Methyl protocatechuate

Methyl protocatechuate (Methyl 3,4-dihydroxybenzoate, 3,4-Dihydroxybenzoic acid methyl ester, Protocatechuic Acid Methyl Ester) is also known as Protocatechuic Acid Methyl Ester. Protocatechuic Acid, a dihydroxybenzoic acid, is a major metabolite of antioxidant polyphenols found in green tea with antioxidant and anti-inflammatory effects.

GC31699 Scopoletin (Gelseminic acid)

东莨菪内酯; Gelseminic acid; Chrysatropic acid

A natural coumarin

GC31596 Osajin (CID 95168)

CID 95168; NSC 21565

Osajin (CID 95168) 是存在于 Maclura pomifera 果实中的主要生物活性异黄酮，具有抗肿瘤、抗氧化和抗炎活性。

GC31511 Sinapinic acid (Sinapic acid)

芥子酸; Sinapic acid

A phenylpropanoid hydroxycinnamic acid with diverse biological activities

GC31186 Citicoline sodium salt

胞磷胆碱钠; Cytidine diphosphate-choline sodium; CDP-Choline sodium; Cytidine 5'-diphosphocholine sodium

An intermediate in the synthesis of phosphatidylcholine

GC30896 4-Hydroxybenzyl alcohol

对羟基苯甲醇

A phenol with diverse biological activities

GC30788 L-Glutamic acid monosodium salt (Monosodium glutamate)

谷氨酸单钠盐

L-Glutamic acid monosodium salt is the sodium salt of glutamic acid, found naturally in tomatoes, cheese and other foods. L-Glutamic acid monosodium salt acts as an excitatory transmitter and an agonist at all subtypes of glutamate receptors (metabotropic, kainate, NMDA, and AMPA). (S)-Glutamic acid shows a direct activating effect on the release of DA from dopaminergic terminals.

GC30266 L-SelenoMethionine

L-硒代蛋氨酸

A naturally occurring amino acid with antioxidant properties

GC30240 Calcium dobesilate

羟苯磺酸钙

Calcium dobesilate (calcium dihydroxy-2,5-benzenesulfonate) is a small molecule that has been widely used for treating diabetic retinopathy and chronic venous insufficiency.