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Home >> Signaling Pathways >> Apoptosis >> p53

p53

The p53 tumor suppressor is a 53 kDa nuclear phosphoprotein of 393 amino acids that is encoded by the TP53 gene (20 kb with 11 exons and 10 introns) and characterized by the presence of several structural and functional domains, including a N-terminus, a central core domain, a C-terminal region, a strongly basic carboxyl-terminal regulatory domain, a nuclear localization signal sequence and three nuclear export signal sequence. The p53 is considered as a major “guardian of genome” for its activities in a wide range of cellular events, including cell-cycle regulation, induction of apoptosis, gene amplification, DNA recombination, chromosomal segregation and cellular senescence.

Products for  p53

  1. Cat.No. 产品名称 Information
  2. GC35511 BI-0252 BI-0252 是一种具有口服活性，选择性的 MDM2-p53 抑制剂，IC50 值为 4 nM。 BI-0252 可诱导异种移植小鼠 SJSA-1 的所有动物肿瘤消退，同时诱导肿瘤蛋白p53 (TP53) 靶基因和凋亡标志物。
  3. GC35367 APG-115

    AA-115

     APG-115 (APG-115) 是一种具有口服活性的 MDM2 蛋白抑制剂，与 MDM2 蛋白结合，IC50 和 Ki 值分别为 3.8 nM 和 1 nM。 APG-115 阻断 MDM2 和 p53 的相互作用，并以 p53 依赖性方式诱导细胞周期停滞和细胞凋亡。
  4. GC44652 PK7242 (maleate) An inducer of reactivation of mutant p53
  5. GC43565 Doxorubicinol (hydrochloride)

    13-Dihydroadriamycin hydrochloride

     A doxorubicin metabolite
  6. GC43408 Deoxycholic Acid (sodium salt hydrate)

    一水脱氧胆酸钠,Cholanoic Acid sodium hydrate; Desoxycholic acid sodium hydrate

     A secondary bile acid
  7. GC43297 Coenzyme Q2

    辅酶Q2

     A biosynthetic precursor to CoQ10 and an inhibitor of mitochondrial complex I
  8. GC43239 Chk2 Inhibitor

    SC-203885

     A Chk2 inhibitor
  9. GC43190 CAY10682 A dual inhibitor of p53-Mdm2 interaction and NF-κB signaling
  10. GC43189 CAY10681 A dual modulator of p53-MDM2 interaction and NF-κB signaling
  11. GC42785 Amifostine (hydrate)

    氨磷汀三水合物,WR2721 trihydrate

     A broad-spectrum radioprotective thiol
  12. GC42586 6α-hydroxy Paclitaxel

    6-羟基泰素

     A metabolite of paclitaxel
  13. GC41643 9(Z),11(E),13(E)-Octadecatrienoic Acid

    αEleostearic Acid, αESA, LAF 237

     A polyunsaturated fatty acid
  14. GC40785 9(Z),11(E),13(E)-Octadecatrienoic Acid ethyl ester

    αESA ethyl ester, Ethyl αeleostearate

     A polyunsaturated fatty acid ethyl ester
  15. GC40710 9(Z),11(E),13(E)-Octadecatrienoic Acid methyl ester

    9顺,11反,13反-十八碳三烯酸甲酯

     A polyunsaturated fatty acid methyl ester
  16. GC33384 DPBQ DPBQ是一种p53激活剂。
  17. GC33356 AM-8735 AM-8735是有效，选择性的MDM2抑制剂，IC50值为25nM。
  18. GC32946 PK11007 PK11000 stabilizes the DBD of both WT and mutant p53 proteins by covalent cysteine modification without compromising DNA binding and effective in inducing cell death.
  19. GC32919 Kevetrin hydrochloride (4-Isothioureidobutyronitrile hydrochloride)

    4-Isothioureidobutyronitrile hydrochloride; thioureidobutyronitrile hydrochloride; thioureido butyronitrile hydrochloride

     An activator of p53
  20. GC32911 CTX1

    CTX1是一种新型小分子p53激活剂。
  21. GC32881 Milademetan (DS-3032)

    DS-3032

     Milademetan (DS-3032) (DS-3032) 是一种特异性的、具有口服活性的 MDM2 抑制剂，用于研究急性髓性白血病 (AML) 或实体瘤。 Milademetan (DS-3032) (DS-3032) 诱导 G1 细胞周期停滞、衰老和凋亡。
  22. GC19312 RO8994 An inhibitor of MDM2-p53 interaction
  23. GC19268 NVP-HDM201

    NVP-HDM201; HDM201

     NVP-HDM201 (NVP-HDM201) 是一种有效的、口服生物利用度高且高度特异性的 p53-MDM2 相互作用抑制剂。
  24. GC19257 MX69 An inhibitor of the MDM2 protein and XIAP RNA interaction
  25. GC18677 YMU1 A thymidylate kinase inhibitor
  26. GC18624 Roslin-2

    Benzylhexamethylenetetramine bromide

     A reactivator of p53
  27. GC15613 p-nitro-Cyclic Pifithrin-α

    Cyclic pifithrin-α-p-nitro,p-nitro-Cyclic PFT-α

     A cell-permeable form of cyclic PFT-α
  28. GC15258 GN25 Inhibits p53-Snail binding
  29. GC15225 COTI-2 An activator of mutant forms of p53
  30. GC15812 p-nitro-Pifithrin-α

    p-nitro-PFT-α

     A cell-permeable inactivator of p53
  31. GC15394 CBL0137 (hydrochloride)

    CBL0137盐酸盐,CBLC137,Curaxin 137

     An activator of p53 and inhibitor of NF-κB
  32. GC14634 CBL0137

    CBLC137,Curaxin 137

     An activator of p53 and inhibitor of NF-κB
  33. GC15946 ReACp53 ReACp53 可以抑制 p53 淀粉样蛋白的形成并挽救癌细胞系中的 p53 功能。
  34. GC16151 NSC348884

    N1,N1,N2,N2-四[(6-甲基-1H-苯并咪唑-2-基)甲基]-1,2-乙二胺

     A nucleophosmin inhibitor
  35. GC18136 BH3I-1

    BHI1; BH 3I1

     An inhibitor of anti-apoptotic Bcl-2 proteins
  36. GC16179 NSC59984 A p53 reactivator
  37. GC11711 ONC201

    TIC10

     A TRAIL-inducing compound
  38. GC11547 MI-773 (SAR405838)

    MI-77301

     An inhibitor of MDM2-p53 protein-protein interactions
  39. GC17262 Pifithrin-β

    5,6,7,8-四氢-2-(4-甲基苯基)-咪唑并[2,1-B]苯并噻唑,PFT β; Cyclic Pifithrin-α

     An inactivator of p53
  40. GC11445 YH239-EE A prodrug form of YH 239
  41. GC12647 NVP-CGM097

    CGM097

     An inhibitor of the MDM2-p53 interaction
  42. GC16296 MI-773

    (2'R,3S,4'S,5'R)-6-氯-4'-(3-氯-2-氟苯基)-2'-(2,2-二甲基丙基)-1,2-二氢-N-(反式-4-羟基环己基)-2-氧代螺[3H-吲哚-3,3'-吡咯烷]-5'-甲酰胺

     MI-773 是一种有效的 MDM2-p53 蛋白-蛋白相互作用 (PPI) 抑制剂，对 MDM2 具有高结合亲和力 (Kd=8.2 nM)。 MI-773 具有抗肿瘤活性。
  43. GC14755 Inauhzin

    INZ

     A selective SIRT1 inhibitor
  44. GC15828 AMG232

    2-((3R,5R,6S)-5-(3-氯苯基)-6-(4-氯苯基)-1-((S)-1-(异丙基磺酰基)-3-甲基丁烷-2-基)-3-甲基-2-氧代哌啶-3-基)乙酸,AMG 232;AMG-232

     An inhibitor of the MDM2 and p53 interaction
  45. GC12337 Tenovin-3

    Tenovin 3;Tenovin3

     A small molecule activator of p53
  46. GC16436 Tenovin-6 A small molecule activator of p53
  47. GC12508 Nutlin-3b

    4-[[(4R,5S)-4,5-双(4-氯苯基)-4,5-二氢-2-[4-甲氧基-2-(1-甲基乙氧基)苯基]-1H-咪唑-1-基]羰基]-2-哌嗪酮

     The less active enantiomer of (–)-nutlin-3
  48. GC11247 PRIMA-1MET

    APR-246

     A re-activator of the apoptotic function of mutant p53 proteins
  49. GC11065 Pifithrin-μ

    NSC 303580

     Inhibitor of p53-mediated apoptosis
  50. GC10896 Cyclic Pifithrin-α hydrobromide

    环状抑制剂-Α氢溴酸盐,Pifithrin-β

     A stable inhibitor of p53
  51. GC11557 WR 1065

    硫代乙基氨基乙基胺盐酸盐

     A radioprotective agent

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