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Home >> Signaling Pathways >> Apoptosis >> TNF-α

TNF-α(肿瘤坏死因子-α)

Tumor necrosis factor alpha (TNF-α), belongs to the superfamily of TNF/TNFR cytokine superfamily, is a type II transmembrane protein (mTNF) with an intracellular N terminus that is produced as 26 kDa membrane-bound cytokine comprised of 233 amino acids. TNF-α also exists as a soluble cytokine (sTNF), which is a non-covalently bound 17 kDa trimer (157 amino acids with a 76 amino acid presequence) resulted from the cleavage of mTNF by TNF-α converting enzyme (TACE). Two distinct and highly affinitive receptors of TNF-α have been identified, including TNFR55 (a 55 kDa receptor) and TNFR75 (a 75 kDa receptor), through which multiple activities of TNF-α are mediated. TNF-α has been found to be involved in maintenance and homeostasis of the immune system, inflammation and host defence as well as a variety of pathological processes.

Products for  TNF-α

  1. Cat.No. 产品名称 Information
  2. GC65031 Belimumab

    贝利木单抗,LymphoStat B

     Belimumab (LymphoStat B) 是一种人 IgG1Λ 单克隆抗体，可抑制 B 细胞激活因子 (BAFF)。Belimumab 可用于系统性红斑狼疮 (SLE) 研究。
  3. GC64864 EJMC-1 EJMC-1 是一种中度有效的 TNF-α 抑制剂，IC50 为 42 μM。
  4. GC64839 Varlilumab

    伐立鲁单抗,CDX-1127

     Varlilumab (CDX-1127) 是一种首创的人 IgG1 抗 CD27 单克隆抗体。Varlilumab 具有抗肿瘤活性。
  5. GC64767 ISIS 104838 ISIS 104838是一种反义寡核苷酸药物，可减少肿瘤坏死因子 (TNF-alpha) 的产生。TNF-alpha 可以导致类风湿关节炎关节疼痛和肿胀。
  6. GC63972 5,7-Dimethoxyflavanone

    (2R)-5,7-二甲氧基二氢黄酮

     5,7-Dimethoxyflavanone 在 Ames 试验中对鼠伤寒 TA100 和 TA98 菌株的 MeIQ 诱变表现出较强的抗诱变活性，也能显著且剂量依赖性地抑制炎症介质:一氧化氮(NO)和细胞因子(TNF-α和IL-12)。
  7. GC63231 TNF-α-IN-2 TNF-α-IN-2 是一种有效和具有口服活性的肿瘤坏死因子 α (TNFα) 抑制剂，在 HTRF 分析中的 IC50 值为 25 nM。结合时，TNF-α-IN-2 会使 TNFα 三聚体变形，当三聚体与 TNFR1 结合时会导致异常信号传导。TNF-α-IN-2 可用于类风湿关节炎的研究。
  8. GC62451 Benpyrine Benpyrine 是一种高度特异性的具有口服活性的 TNF-α 抑制剂，KD 值为 82.1 μM。Benpyrine 与 TNF-α 紧密结合并阻断其与 TNFR1 的相互作用，IC50 值为 0.109 µM。Benpyrine 可用于 TNF-α 介导的炎症和自身免疫性疾病的研究。
  9. GC62400 LEESGGGLVQPGGSMK acetate LEESGGGLVQPGGSMK acetate，一种蛋白水解肽，是 Infliximab 的一种成分，可用于 Infliximab 的定量分析。Infliximab 是一种与 TNF-α 特异性结合的嵌合单克隆 IgG1 抗体。
  10. GC62346 UCB-9260 UCB-9260 is an orally active inhibitor that inhibits TNF signalling by stabilising an asymmetric form of the trimer. UCB-9260 binds TNF with Kd of 13 ?nM. UCB-9260 also inhibits NF-κB with IC50 of 202?nM after TNF stimulation.
  11. GC61533 UTL-5g

    GBL-5g

     UTL-5g (GBL-5g) is a novel small-molecule TNF-α inhibitor which can lower hepatotoxicity, nephrotoxicity and myelotoxicity induced by Cisplatin.DMSO is not recommended to dissolve platinum-based drugs, which can easily lead to drug inactivation.
  12. GC48907 Metaxalone-d6

    AHR438-d6; NSC170959-d6

     An internal standard for the quantification of metaxalone
  13. GC48827 Flufenamic Acid-d4

    FFA-d4, Fluphenamic Acid-d4

     An internal standard for the quantification of flufenamic acid
  14. GC48292 α-MSH (human, mouse, rat, porcine, bovine, ovine) (trifluoroacetate salt)

    Α-促黑激素,α-Melanocyte-Stimulating Hormone TFA

     A peptide hormone
  15. GC48202 Treprostinil (diethanolamine salt)

    曲前列尼尔二乙醇胺盐,UT-15C

     An agonist of IP2, DP2, and EP2 receptors
  16. GC48195 trans-trismethoxy Resveratrol-d4

    (E)-5-2-(4-hydroxyphenyl)ethenyl-1,3-benzene diol-d4, TMS-d4, trans-3,5,4'-Trimethoxystilbene-d4

     An internal standard for the quantification of trans-trismethoxy resveratrol
  17. GC48099 SR 12460 An IKKβ NBD mimetic
  18. GC48098 SR 12343 An IKKβ NBD mimetic
  19. GC47544 Lauric Acid-13C

    十二(烷)酸

     An internal standard for the quantification of lauric acid
  20. GC46862 Apigenin-d5

    3,6,8,3’,5’-d5-Apigenin, Chamomile-d5, Flavone-d5, Versulin-d5

     An internal standard for the quantification of apigenin
  21. GC60796 D-Trimannuronic acid

    D-甘露糖醛酸三糖

     D-Trimannuronicacid是一种从海藻中提取的藻酸盐低聚物，可以诱导小鼠巨噬细胞分泌TNF-α。D-Trimannuronicacid可用于疼痛和血管性痴呆的研究。
  22. GC60225 Licarin A

    利卡灵A,(+)-Licarin A

     LicarinA((+)-LicarinA)，可从多种植物中分离得到，显着降低二硝基苯肼-人血清白蛋白(DNP-HSA)刺激的RBL-2H3细胞。具有抗过敏作用。LicarinA降低TNF-α和PGD2产生，和COX-2表达。
  23. GC39815 Semapimod tetrahydrochloride

    CNI-1493; CPSI-2364 tetrahydrochloride

     Semapimod tetrahydrochloride (CNI-1493) 是促炎细胞因子产生 (proinflammatory cytokine) 的抑制剂，可抑制TNF-α、IL-1β 和 IL-6。Semapimod tetrahydrochloride 抑制巨噬细胞 p38 MAPK 和一氧化氮生成。Semapimod tetrahydrochloride 抑制 TLR4 信号 (IC50≈0.3 μM)。Semapimod tetrahydrochloride 在多种炎症和自身免疫性疾病中具有潜在的作用。
  24. GC50196 Simvastatin - d6

    六氘代辛伐他汀,MK 733-d6

     An internal standard for the quantificaition of simvastatin
  25. GC39070 Negletein

    黄芩素-7-甲醚; 5,6-Dihydroxy-7-methoxyflavone

     Negletein 是一种神经保护剂，可增强神经生长因子的作用并诱导 PC12 细胞中的神经突向外生长。Negletein 通过抑制 TNF-α 和 IL-1β 表现出有希望的抗炎活性，其 IC50 值分别为 16.4 和 10.8 μM。
  26. GC46015 KY 05009 A TNIK inhibitor
  27. GC45960 9c(i472)

    15-LOX-1 Inhibitor i472

     A 15-LO-1 inhibitor
  28. GC38868 TRAF-STOP inhibitor 6877002 TRAF-STOP inhibitor 6877002是一种抑制CD40-TRAF6相互作用的选择性抑制剂（TRAF-STOPs）。
  29. GC45798 Rhein-13C4

    1,8-二羟基-3-羧基蒽醌

    An internal standard for the quantification of rhein
  30. GC45772 6(5H)-Phenanthridinone

    6(5H)-菲啶酮

     An inhibitor of PARP1 and 2
  31. GC37555 Roquinimex

    罗喹美克,Linomide; FCF89; ABR212616

     An immunomodulator with diverse biological activities
  32. GC36106 Gamma-glutamylcysteine (TFA)

    γ-Glutamylcysteine TFA

     Gamma-glutamylcysteine (TFA) ((γ-glutamylcysteine (TFA))是谷胱甘肽 (GSH) 合成的中间体，一种作为抗氧化酶谷胱甘肽过氧化物酶 (GPx) 的必需辅助因子的二肽。 Gamma-glutamylcysteine (TFA) 上调抗炎细胞因子 IL-10 的水平，降低促炎细胞因子 (TNF-α，IL-6 和 IL-1β) 的水平，并减弱在寡聚 Aβ40 处理的星形胶质细胞中金属蛋白酶活性的变化。
  33. GC35523 Bioymifi

    DR5 Activator

     A DR5 agonist
  34. GC35440 AX-024 An inhibitor of the CD3ε-Nck interaction
  35. GC35377 Apratastat

    N-羟基-4-[[4-[(4-羟基-2-丁炔基)氧基]苯基]磺酰基]-2,2-二甲基-3-硫代吗啉甲酰胺,TMI-005

     An inhibitor of ADAM17 and MMPs
  36. GC35184 7,3',4'-Tri-O-methylluteolin

    木犀草素-7,3',4'-三甲醚; 5-Hydroxy-3',4',7-trimethoxyflavone

     7,3',4'-Tri-O-methylluteolin (5-Hydroxy-3',4',7-trimethoxyflavone) 是一种来自草药马鞭草科 (Lippia nodiflora L.) 的类黄酮，Lippia nodiflora L. 已被证明具有抗炎，解热，镇咳，抗糖尿病，抗癌和抗黑素生成特性。7,3',4'-Tri-O-methylluteolin 以浓度依赖方式明显抑制促炎细胞因子，如 TNF-α，IL-6 和 IL-1β。7,3',4'-Tri-O-methylluteolin 显著降低在转录水平的诱导型一氧化氮合酶和环加氧酶-2 的 mRNA 表达。
  37. GC44943 sPLA2 Inhibitor

    KH064, Secretory Phospholipase A2 Inhibitor

     An orally active inhibitor of sPLA2-IIA
  38. GC44388 NF-κB Control

    SN50M

     A negative control peptide used with NF-κB inhibitor
  39. GC44097 LY303511 (hydrochloride) An inhibitor of cell proliferation
  40. GC43894 IKK2 Inhibitor VI

    5-Phenyl-2-ureidothiophene-3-carboxylic Acid Amide

     An inhibitor of IKK2
  41. GC43368 D,L-1′-Acetoxychavicol Acetate

    D,L-1\'-乙酰氧基胡椒酚乙酸酯

     A natural exportin 1 inhibitor
  42. GC43190 CAY10682 A dual inhibitor of p53-Mdm2 interaction and NF-κB signaling
  43. GC43189 CAY10681 A dual modulator of p53-MDM2 interaction and NF-κB signaling
  44. GC43176 CAY10575

    IKK2 Inhibitor 3, Polo-like Kinase Inhibitor 1

     An IKKβ and Plk1 inhibitor
  45. GC43110 C8 Galactosylceramide (d18:1/8:0)

    Galactosylceramide (d18:1/8:0), N-octanoyl-βD-Galactosylceramide, GalCer(d18:1/8:0)

     A synthetic bioactive sphingolipid
  46. GC42953 BMS 345541 (trifluoroacetate salt) BMS 345541 is a cell permeable inhibitor of the IκB kinases IKKα and IKKβ (IC50s = 4 and 0.3 μM).
  47. GC42925 Berteroin

    5-Methylthiopentyl isothiocyanate

     A natural sulforaphane analog
  48. GC42880 Avenanthramide-C methyl ester Inhibitor of NF-κB activation
  49. GC41342 Terrecyclic Acid

    环酸A

     A sesquiterpene
  50. GC40650 CAY10706 A TrxR inhibitor
  51. GC19533 Infliximab

    英夫利昔单抗,Avakine; CT-P13

    英夫利昔单抗是一种嵌合单克隆 IgG1 抗体，可特异性结合 TNF-α。

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