TNF-α(肿瘤坏死因子-α)

Tumor necrosis factor alpha (TNF-α), belongs to the superfamily of TNF/TNFR cytokine superfamily, is a type II transmembrane protein (mTNF) with an intracellular N terminus that is produced as 26 kDa membrane-bound cytokine comprised of 233 amino acids. TNF-α also exists as a soluble cytokine (sTNF), which is a non-covalently bound 17 kDa trimer (157 amino acids with a 76 amino acid presequence) resulted from the cleavage of mTNF by TNF-α converting enzyme (TACE). Two distinct and highly affinitive receptors of TNF-α have been identified, including TNFR55 (a 55 kDa receptor) and TNFR75 (a 75 kDa receptor), through which multiple activities of TNF-α are mediated. TNF-α has been found to be involved in maintenance and homeostasis of the immune system, inflammation and host defence as well as a variety of pathological processes.

Products for TNF-α

Cat.No. 产品名称 Information
GC34579 Etanercept
依那西普
Etanercept是一种竞争性肿瘤坏死因子（TNF）抑制剂，抑制TNF-α和TNF-β与细胞表面受体的结合。
GC34513 C25-140 C25-140 is a small-molecule inhibitor of TRAF6-Ubc13 interaction. C25-140 directly binds to TRAF6, thereby blocking the interaction of TRAF6 with Ubc13, and as a consequence lowers TRAF6 activity. C25-140 impedes NF-κB activation in various immune and inflammatory signaling pathways also in primary human and murine cells.
GC34214 Adalimumab (Anti-Human TNF-alpha, Human Antibody)
阿达木单抗; Anti-Human TNF-alpha, Human Antibody

阿达木单抗（抗人 TNF-α，人抗体）是治疗类风湿性关节炎的主要疗法之一。
GC33934 DCVC
S-[(1E)-1,2-dichloroethenyl]--L-cysteine
DCVC (S-[(1E)-1,2-dichloroethenyl]--L-cysteine) 是三氯乙烯 (TCE) 的生物活性代谢物。
GC33826 C 87 C87是一种新型小分子TNFα抑制剂;高效抑制TNFα诱导的细胞毒性，IC50值为8.73μM。
GC33825 Taurochenodeoxycholic acid (12-Deoxycholyltaurine)
牛磺鹅去氧胆酸; 12-Deoxycholyltaurine

A quantitative analytical standard guaranteed to meet MaxSpec identity, purity, stability, and concentration specifications
GC33337 CDC801
CDC801是一种强效的磷酸二酯酶4(PDE4)和肿瘤坏死因子-α(TNF-α)抑制剂。IC50分别为1.1μM和2.5μM。
GC33330 Cynaropicrin
菜蓟苦素
A sesquiterpene lactone
GC33133 SPD304 A small-molecule inhibitor of TNFα activity
GC31739 Hispidol ((Z)-Hispidol)
(Z)-Hispidol
Hispidol ((Z)-Hispidol) ((Z)-Hispidol ((Z)-Hispidol)) 是炎症性肠病的潜在治疗剂；抑制 TNF-α；诱导单核细胞与结肠上皮细胞的粘附，IC50 为 0.50 μM.
GC31692 Homoplantaginin
高车前苷
A flavonoid glycoside with antioxidant and anti-inflammatory activities
GC30910 Eucalyptol (1,8-Cineole)
NSC 6171
Eucalyptol是5-HT3受体,钾通道,TNF-α和IL-1β的抑制剂。
GC19046 AX-024 hydrochloride An inhibitor of the CD3ε-Nck interaction
GC18796 Herbicidin A
除莠菌素A
An adenine nucleoside antibiotic with herbicidal activity
GC18392 Cellocidin
乙炔二羰酰胺
An antibiotic
GC17632 Maslinic Acid
山楂酸; Crategolic acid; 2α-Hydroxyoleanolic acid
Maslinic Acid是一种五环三萜酸，广泛存在于橄榄和其他植物中。Maslinic Acid具有抗炎、抗氧化、抗肿瘤、降血糖和神经保护等多种生物活性。
GC11659 R-7050
TNF-α Antagonist III
R-7050 是一种新型细胞渗透性三唑并喹喔啉化合物，可选择性抑制 TNF-α；诱导细胞信号传导。
GC15573 GSK481 A selective inhibitor of RIP1
GC14500 CPI-1189
N-叔丁基-4-乙酰氨基苯甲酰胺
A benzamide
GC16673 N-Formyl-Met-Leu-Phe
酪胺盐酸盐,fMLP; N-Formyl-MLF
N-Formyl-Met-Leu-Phe是一种内源性趋化肽，也是甲酰肽受体1（FPR1）的激动剂，Ki值为38 nM。
GC16007 Methylthiouracil
甲硫氧嘧啶; MTU
甲基硫氧嘧啶是一种抗甲状腺药物。
GC13473 Lenalidomide hemihydrate
来那度胺半水合物; CC-5013 hemihydrate
An analog of thalidomide
GC10350 TIC10 isomer
ONC201 isomer
TIC10异构体是TIC10的异构体。
GC11167 Necrostatin 2
(5R)-5-[(7-氯-1H-吲哚-3-基)甲基]-3-甲基-2,4-咪唑烷二酮,MTH-DL-Tryptophan, Necroptotic Inhibitor
A potent inhibitor of necroptosis
GC12045 LY 303511
8-苯基-2-(1-哌嗪基)-4H-1-苯并吡喃-4-酮,LY-303511;LY303511
An inhibitor of cell proliferation
GC14015 Lenalidomide hydrochloride
Revlimid hydrochloride;CC-5013 hydrochloride;CC5013 hydrochloride;CC 5013 hydrochloride
An analog of thalidomide
GC10420 Apremilast (CC-10004)
阿普司特; CC-10004
An orally available PDE4 inhibitor
GC11751 QNZ (EVP4593)
N4-[2-(4-苯氧基苯基)乙基]-4,6-喹唑啉二胺,EVP4593
An inhibitor of NF-κB activation
GC17054 Thalidomide
沙利度胺
An immunomodulatory compound with diverse biological activities
GC11008 Necrostatin-1
MTH-DL-Tryptophan,Nec-1
Necrostatin-1主要作用于细胞中的RIP1，Necrostatin-1是一种RIP1激酶抑制剂，IC50值为0.32 mM。
GC11697 Pomalidomide (CC-4047)
泊马度胺; CC-4047
An inhibitor of cereblon
GC14976 Lenalidomide (CC-5013)
来那度胺; CC-5013
An analog of thalidomide
GN10280 Sinensetin
5,6,7,3',4'-五甲氧基黄酮,Pedalitin permethyl ether
An anti-inflammatory flavone
GN10030 Fisetin
漆黄素
Fisetin是一种天然黄酮醇，存在于许多水果和蔬菜中，具有多种生物活性。
GN10216 Shikonin
紫草素; C.I. 75535; Isoarnebin 4
Shikonin是一种含醌的天然产物。Shikonin是一种有效的TMEM16A氯离子通道抑制剂，IC₅₀为6.5μM。
GN10254 Ginsenoside Rc
人参皂苷 Rc; Panaxoside Rc
A saponin with diverse biological activities
GN10151 Geraniin
老鹳草素
A tannin with diverse biological activities
GN10727 Forsythoside B
连翘酯苷 B
Forsythoside B是从传统中药植物连翘的叶子中分离的一种苯乙醇苷，具有多种生物活性，能够用于治疗炎症性疾病和促进血液循环。
GN10429 Neochlorogenic acid
新绿原酸; trans-5-O-Caffeoylquinic acid
A phenolic compound with diverse biological activities
GN10415 Astilbin
落新妇苷
A flavonoid with diverse biological activities
GN10538 Ginsenoside Rh1
人参皂苷 Rh1; Prosapogenin A2; Sanchinoside B2; Sanchinoside Rh1
A steroid glycoside with diverse biological activities
GN10217 Hypaconitine
次乌头碱
A diterpene alkaloid with diverse biological activities
GN10055 Mulberroside A
桑皮苷 A
A phenol with diverse biological activities
GN10335 Mesaconitine
中乌头碱；新乌头碱；美沙乌头碱；新乌碱
新乌头碱是乌头属植物的主要活性成分。
GC15083 Celastrol
雷公藤红素; Celastrol
Celastrol是一种蛋白酶体抑制剂，有效且优先的抑制纯化的20S蛋白酶体，IC₅₀ 为2.5 μM。