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Home >> Signaling Pathways >> Neuroscience

Neuroscience(神经科学)

Neuroscience

Neurons communicate with each other, effector organs and sensory organs through the neurotransmitter – receptor pathway at synapses. Neurotransmitters can be divided into 4 major groups: 1. Amino acids (glumate, aspartate, serine, glycine and GABA); 2. Monoamines (norepinephrine, epinephrine, dopamine, histamine, and serotonin); 3. Peptides (opioid peptides, substance P, somatostatin); and 4. Others (acetylcholine, NO, nucleosides). read more

Products for  Neuroscience

  1. Cat.No. 产品名称 Information
  2. GC91849 Autocamtide-2-related Inhibitory Peptide (trifluoroacetate salt) Autocamtide-2-related inhibitory peptide is a calmodulin-dependent protein kinase II (CaMKII) inhibitor (IC50 = 40 nM) that was designed based on the sequence around the autophosphorylation site (Thr286/Thr287) in the autoinhibitory domain of the protein kinase.
  3. GC91703 AL 34662 (formate) AL 34662 is an agonist of the serotonin (5-HT) receptor subtype 5-HT2.
  4. GC91690 TASP0277308 TASP0277308 is a sphingosine-1-phosphate receptor 1 (S1P1) antagonist (IC50 = 4.2 nM).
  5. GC91681 Loxoprofen-SRS Loxoprofen-SRS is a non-steroidal anti-inflammatory drug (NSAID) and COX inhibitor (IC50s = 0.5 and 0.39 for recombinant human COX-1 and COX-2, respectively) and an active metabolite of the prodrug loxoprofen .
  6. GC91680 4-Acetamido Antipyrine

    4-AAAP,NSC 331807

     4-Acetamido antipyrine (4-AAAP) is an active metabolite of the non-opioid analgesic and antipyretic prodrug metamizole .
  7. GC91641 4-Hydroxy-1-(2-phenylethyl)piperidine 4-Hydroxy-1-(2-phenylethyl)piperidine is a building block that has been used in the synthesis of ligands of the muscarinic acetylcholine receptor (mAChR) or sigma non-opioid intracellular receptor 1 (σ1 receptor).
  8. GC91621 WLB-89462 WLB-89462 is a ligand of sigma intracellular receptor 2 (σ2 receptor).
  9. GC91544 Fmoc-L-Lys[Oct-(OtBu)-Glu-(OtBu)-AEEA-AEEA]-OH

    Fmoc-Lys(tBuOCO-(CH2)16-CO-Glu(AEEA-AEEA)-OtBu)-OH

     Fmoc-L-Lys[Oct-(OtBu)-Glu-(OtBu)-AEEA-AEEA]-OH is a building block in the synthesis of the glucagon-like peptide 1 receptor (GLP-1R) agonist semaglutide .
  10. GC91507 CP 93,129 CP 93,129 is an agonist of the serotonin (5-HT) receptor subtype 5-HT1B.
  11. GC91497 EB 47 (hydrochloride) EB 47 is an inhibitor of poly(ADP-ribose) polymerase 1 (PARP1; IC50 = 45 nM) and a dual site inhibitor of tankyrase 2 (TNKS2; IC50 = 45 nM).
  12. GC91493 Semaglutide Side Chain Semaglutide side chain is a synthetic intermediate.
  13. GC91492 Propiverine N-oxide Propiverine N-oxide is an active metabolite of the muscarinic acetylcholine receptor antagonist propiverine .
  14. GC91488 Proxymetacaine (hydrochloride)

    Proparacaine

     Proxymetacaine is an anesthetic.
  15. GC72723 p-Hydroxybenzaldehyde-d4 p-Hydroxybenzaldehyde-d4是氘标记的对羟基苯甲醛。
  16. GC72625 (±)-Coniine hydrochloride (±)-Coniine hydrochloride2-丙基哌啶盐酸盐是一种强效的nAChR激动剂，EC50值为0.3mM。
  17. GC72617 hMAO-B-IN-5 hMAO-B-IN-5（B15）是一种强效、选择性和可逆的人单胺氧化酶hMAO-B抑制剂，IC50为0.12μM。
  18. GC72246 αC-Conotoxin PrXA αC-Conotoxin PrXA是一种麻痹性肽神经毒素和竞争性nAChR拮抗剂，IC50分别为1.8 nM（α1β1εδ，成人）和3.0 nM（β1γδ，胎儿）。
  19. GC72222 Survodutide Survodutide（BI 456906）是一种强效的选择性胰高血糖素受体/GLP-1受体（GCGR/GLP-1R）双重激动剂，在CHO-K1细胞中的EC50分别为0.52 nM和0.33 nM。
  20. GC72212 Substance P (5-11) (TFA) Substance P (5-11) (TFA)TFA是P物质P的C末端七肽，是一种神经肽。
  21. GC72206 Autocamtide-3 acetate Autocamtide-3 acetate含有Thr287的13个氨基酸的肽是选择性CaMKII（Ca2+/钙调素依赖性激酶II）（CaMK）底物。
  22. GC72190 Cagrilintide Cagrilintide是一种正在研究的新型长效酰化amylin类似物，作为非选择性amylin受体(AMYR)和降钙素G蛋白偶联受体(CTR)激动剂。
  23. GC72117 FITC-α-Bungarotoxin FITC-α-Bungarotoxin为FITC标记的α-Bungarotoxin。
  24. GC72115 [D-Pro2] Spantide I TFA [D-Pro2] Spantide I TFA是Spantide的类似物。
  25. GC72110 α-CGRP(human) TFA α-CGRP(human) TFA是一种由37个氨基酸组成的调节神经肽。
  26. GC72093 α-CGRP (mouse, rat) (TFA) α-CGRP (mouse, rat) (TFA)，一种主要在神经肌肉接头表达的神经肽降钙素基因相关肽CGRP，是一种强效的血管舒张剂。
  27. GC72054 Obovatol Obovatol是一种从厚朴叶中分离出来的联苯醚木脂素。
  28. GC71717 Cinitapride Cinitapride是非选择性5-HT1和5-HT4受体激动剂和5-HT2和D2拮抗剂。
  29. GC71684 Propantheline-d3 bromide Propantheline-d3 bromide是氘标记的溴化丙烷。
  30. GC71660 Tiotropium bromide monohydrate Tiotropium bromide monohydrate是一种抗胆碱能和支气管扩张剂，也是毒蕈碱受体拮抗剂。
  31. GC71653 Domperidone monomaleate Domperidone monomaleate是一种口服活性和选择性多巴胺-2受体拮抗剂。
  32. GC71641 Tropicamide-d3 Tropicamide-d3是氘标记的托吡卡胺。
  33. GC71634 (R)-Oxybutynin hydrochloride (R)-Oxybutynin hydrochloride盐酸奥昔布宁的R-异构体，是一种口服活性毒蕈碱受体拮抗剂。
  34. GC71620 Venlafaxine-d6 Venlafaxine-d6是氘标记的文拉法辛。
  35. GC71618 rel-Sertraline-d3 hydrochloride rel-Sertraline-d3 hydrochloride是氘标记的盐酸舍曲林。
  36. GC71604 Ondansetron-d3 hydrochloride Ondansetron-d3 hydrochloride是氘标记的盐酸昂丹司琼。
  37. GC71603 Ondansetron-d5 Ondansetron-d5是氘标记的昂丹司琼。
  38. GC71602 Propyphenazone-d3 Propyphenazone-d3是氘标记的苯丙酮。
  39. GC71594 Tolterodine-d14 hydrochloride Tolterodine-d14 hydrochloride是氘标记的盐酸托特罗定。
  40. GC71582 (Rac)-5-Hydroxymethyl Tolterodine hydrochloride (Rac)-5-Hydroxymethyl Tolterodine hydrochloride是托特罗定的活性代谢产物，是mAChR拮抗剂。
  41. GC71523 Enerisant hydrochloride Enerisant hydrochloride是一种选择性、竞争性和口服活性的组胺H3受体（HRH3）拮抗剂/反向激动剂，对人和大鼠HRH3的IC50分别为2.89 nM和14.5 nM。
  42. GC71511 Dexpramipexole-d3 dihydrochloride Dexpramipexole-d3 dihydrochloride是氘标记的右旋普拉克索。
  43. GC71497 ZCAN262 ZCAN262（化合物6）是AMPA调制器。
  44. GC71484 MAO-B-IN-30 MAO-B-IN-30（化合物IS7）是一种强效、选择性和跨血脑屏障的MAO-B抑制剂，MAO-a和MAO-B的IC50值分别为19.176和0.082µM。
  45. GC71436 Brexpiprazole-d8-1 Brexpiprazole-d8-1是氘标记的布雷哌唑。
  46. GC71334 mAChR antagonist 1 mAChR antagonist 1(化合物4a)是一种mAChR拮抗剂，对M1、M3、M4和M5亚型的Ki值分别为255 nM、121 nM、158 nM和255 nM。
  47. GC71317 Z1078601926 Z1078601926是人多巴胺转运蛋白(hDAT)的变构抑制剂。
  48. GC71283 (Rac)-Rotigotine (Rac)-Rotigotine N-0437是罗替戈汀的外消旋物。
  49. GC71279 5-HT2A receptor agonist-3

    5-HT2A receptor agonist-3Ki=2.5nM、对5-HT2A的选择性是结构相似的5-HT2C受体的124倍。
  50. GC71160 MAO-A/5-HT2AR-IN-1 MAO-A/5-HT2AR-IN-1（化合物I14）是一种强效的MAO-a和5-HT2AR双重抑制剂，IC50值分别为0.004和0.014μM。
  51. GC71157 Dopamine D2 receptor agonist-2 Dopamine D2 receptor agonist-2(化合物36)是一种有效的多巴胺D2受体偏向性激动配体，Ki值为11.2 nM。

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