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Home >> Signaling Pathways >> Neuroscience

Neuroscience(神经科学)

Neuroscience

Neurons communicate with each other, effector organs and sensory organs through the neurotransmitter – receptor pathway at synapses. Neurotransmitters can be divided into 4 major groups: 1. Amino acids (glumate, aspartate, serine, glycine and GABA); 2. Monoamines (norepinephrine, epinephrine, dopamine, histamine, and serotonin); 3. Peptides (opioid peptides, substance P, somatostatin); and 4. Others (acetylcholine, NO, nucleosides). read more

Products for  Neuroscience

  1. Cat.No. 产品名称 Information
  2. GC61382 Xanthoangelol

    黄色当归醇

     Xanthoangelol, a chalcone found in the roots of Angelica keiskei, is a nonselective monoamine oxidase (MAO) inhibitor and a potent dopamine β-hydroxylase (DBH) inhibitor. It has anti-inflammatory, antibiotic and pro-apoptotic activities.
  3. GC61378 VU0238441 VU0238441 is a pan muscarinic acetylcholine receptor (mAChR) positive allosteric modulator (PAM) with EC50 of 2.1 μM, 2.2 μM, 2.8 μM, 3.2 μM and >10 μM for M5, M3, M2, M1 and M4, respectively.
  4. GC61377 VU0119498

    1-(4-溴苄基)吲哚-2,3-二酮

     An M1, M3, and M5 muscarinic receptor positive allosteric modulator
  5. GC61371 Veratric acid

    藜芦酸

     Veratricacid(3,4-Dimethoxybenzoicacid)是从蔬菜和水果中得到的多酚物质，可口服，具有抗氧化、保护心血管和抗炎活性。当细胞受到UVB辐射时，Veratricacid能够减少上调的COX-2表达，降低PGE2和IL-6水平。
  6. GC61367 VAF347 VAF347是一种细胞可渗透且高度亲和力的芳烃受体(AhR)激动剂，可诱导AhR信号传导。VAF347抑制颗粒单核细胞(GM期)前体中CD14+CD11b+单核细胞的发育。VAF347具有抗炎作用。
  7. GC61337 Tolmetin

    托麦汀；托美丁

     Tolmetin (Tolectin) is a nonsteroidal anti-inflammatory drug of the heterocyclic acetic acid derivative class and also exhibits analgesic and antipyretic activity.
  8. GC61317 Tebanicline dihydrochloride

    Ebanicline dihydrochloride; ABT-594 dihydrochloride

     Tebaniclinedihydrochloride(Ebaniclinedihydrochloride)是nAChR的调节物，具有有效的口服止痛活性。抑制cytisine与神经元nAChR的结合的Ki值为37pM。
  9. GC61286 SP-8356 SP-8356, an anti-inflammatory synthetic verbenone derivative, is a CD147 inhibitor with respect to its regulation of breast cancer cell behavior and cancer progression.
  10. GC61281 SKF-83566 A dopamine D1 receptor antagonist
  11. GC61268 SB 243213 A 5-HT2C receptor inverse agonist
  12. GC61256 Rupatadine D4 fumarate

    UR-12592 D4 fumarate

     RupatadineD4fumarate(UR-12592D4fumarate)是Rupatadinefumarate的氘代标记物。RupatadineFumarate(UR-12592Fumarate)富马酸盐是PAF/H1受体双抑制剂，Ki值分别为0.55μM和0.1μM。
  13. GC61255 Rubrofusarin triglucoside

    红镰霉素三葡萄糖苷

     Rubrofusarintriglucoside是一种从决明子种子中分离得到的糖苷化合物，可抑制人单胺氧化酶A(hMAO-A)，IC50为85.5μM。
  14. GC61238 Rehmapicrogenin

    地黄苦苷元

    Rehmapicrogenin可从Rehmanniaglutinosa的根部分离得到，通过抑制iNOS、COX-2和IL-6表现出有效的抗炎作用。
  15. GC61235 Regaloside B

    王百合苷 B

     RegalosideB是一种从Liliumlongiflorum中分离出来的苯丙烷。RegalosideB可以抑制iNOS和COX-2的表达，具有抗炎活性。
  16. GC61234 Rebamipide D4

    瑞巴派特 D4; OPC12759-d4; Proamipide-d4

     An internal standard for the quantification of rebamipide
  17. GC61206 Profenofos

    丙溴磷

     Profenofos是一种乙酰胆碱酯酶抑制有机磷农药，广泛应用于农田作物、蔬菜和水果作物。
  18. GC61193 Piroxicam D3

    吡罗昔康 D3; CP-16171 D3

     An internal standard for the quantification of piroxicam
  19. GC61186 Picrotoxinin

    木防己苦毒宁

     Picrotoxinin, a potent convulsant, is a chloride channel blocker. Picrotoxinin is a noncompetitive GABAA receptor antagonist, which negatively modulates the action of GABA on GABAAA receptors.
  20. GC61180 Phenidone

    菲尼酮

     Phenidone (1-phenyl-3-pyrazolidinone), a dual inhibitor of cyclooxygenase (COX) and lipoxygenase (LOX), is an organic compound that is primarily used as a photographic developer.
  21. GC61167 Paliperidone palmitate

    棕榈酸帕利哌酮,9-Hydroxyrisperidone palmitate

     Paliperidone Palmitate (9-hydroxyrisperidone palmitate) is a palmitate ester of paliperidone, which is a dopamine antagonist and 5-HT2A antagonist of the atypical antipsychotic class.
  22. GC61162 Osthenol

    7-羟基-8-(3-甲基-2-丁烯)-二氢苯并吡喃,Ostenol

     Osthenol(Ostenol)是从独活干根中分离得到的一种前酰化香豆素，是一种可逆的，选择性的竞争性人单胺氧化酶-A(hMAO-A)抑制剂(Ki=0.26µM)。Osthenol对重组hMAO-A具有潜在的选择性抑制作用，IC50为0.74µM，对hMAO-A和hMAO-B表现出较高的选择性指数。
  23. GC61108 Naftidrofuryl oxalate

    草酸萘呋胺; Nafronyl oxalate salt

     Naftidrofuryloxalate(Nafronyloxalatesalt)是在外周血和脑血管病症如血管扩张药的管理中使用的药物,增加细胞氧化能力,且是一种5-HT2受体拮抗剂。
  24. GC61067 Mirtazapine D3

    米氮平 D3; Org3770 D3; 6-Azamianserin D3

     An Analytical Reference Material
  25. GC61038 Mefenamic acid D4

    甲芬那酸 D4

     An internal standard for the quantification of mefenamic acid
  26. GC61017 Lycoramine hydrobromide

    石蒜胺；氢溴酸二氢加兰他敏

     Lycoraminehydrobromide是一种从Lycorisradiate中分离出的加兰他敏的二氢衍生物。Lycoraminehydrobromide是一种有效的乙酰胆碱酯酶(AChE)抑制剂。
  27. GC60966 Ketorolac D5

    酮咯酸D5

     An internal standard for the quantification of ketorolac
  28. GC60965 Keto Ziprasidone KetoZiprasidone是Ziprasidone的杂质。Ziprasidone，一种抗精神药物，是5-HT和多巴胺(dopaminereceptor)受体拮抗剂。
  29. GC60957 Jatrorrhizine hydroxide Jatrorrhizine (Neprotin, Yatrorizine), one of the active constituents of Coptis chinensis Franch, has multiple bioactivities, such as hypoglycemic, antimicrobial, and antioxidant activities. It is an inhibitor of AChE with IC50 of 872 nM and demonstrates >115-fold selectivity for AChE over BuChE.
  30. GC60939 Iproniazid

    异丙烟肼

     Iproniazid (Marsilid, Iprazid) is a non-selective, irreversible monoamine oxidase (MAO) inhibitor (MAOI) that is used as an antidepressive agent.
  31. GC60938 Iprindole

    伊普吲哚

     Iprindole具有抗抑郁的生物活性，是一种弱的去甲肾上腺素和5-HT摄取的抑制剂。
  32. GC60935 Indomethacin sodium hydrate

    吲哚美辛钠盐三水合物; Indometacin sodium hydrate

     A non-selective COX inhibitor
  33. GC60926 Ibuprofen impurity 1

    布洛芬杂质

     Ibuprofenimpurity1是Ibuprofen的杂质。Ibuprofen是COX-1和COX-2的抑制剂，IC50值分别为13μM和370μM，具有抗炎的活性。
  34. GC60924 Hydroxyzine D8

    安泰乐D8

     An internal standard for the quantification of hydroxyzine
  35. GC60917 Hydroxyamine hydrochloride

    羟胺盐酸盐

     Hydroxylammonium chloride (Hydroxylamine hydrochloride) is the hydrochloric acid salt of hydroxylamine, which is a biological intermediate in the nitrification and in the anammox.
  36. GC60915 Hydroxy ziprasidone

    齐拉西酮羟基化杂质

     Hydroxyziprasidone是Ziprasidone的杂质。Ziprasidone，一种抗精神药物，是5-HT和多巴胺(dopaminereceptor)受体拮抗剂。
  37. GC60913 Huperzine C

    石杉碱丙

     HuperzineC是从Huperziaserrate中分离的一种生物碱。HuperzineC是一种乙酰胆碱酯酶(AChE)抑制剂，其IC50值为0.6μM。HuperzineC可用于阿尔茨海默症的研究。
  38. GC60890 Guvacine

    去甲槟榔次碱

     An inhibitor of GABA uptake
  39. GC60886 GSK356278 A selective PDE4 inhbitor
  40. GC60875 GKT136901

    NOX Inhibitor IV

     A dual inhibitor of NOX1 and NOX4
  41. GC60866 Gap 26 TFA Gap 26, a connexin mimetic peptide that composeds of residue no. 63-75 of the extracellular loop 1 of connexin 43 (Cx43), is a gap junction inhibitor. Gap 26 blocks photoliberating inositol-1,4,5-trisphosphate triggers ATP release.
  42. GC60862 GABAA receptor agent 1

    2-(4-氯苯基)-6-硝基-1H-苯并[D]咪唑

     GABAA receptor agent 1 is a high affinity ligand for Gamma-aminobutyric acid A (GABAA) receptor that exerts potent anticonvulsant activity.
  43. GC60846 Flesinoxan

    氟辛克生

     Flesinoxan是一种降压剂，是一种有效的，高亲和力的选择性的5-羟色胺1A(5-HT1A)受体激动剂，EC50值为24nM。Flesinoxan还具有有效的抗焦虑/抗抑郁作用。
  44. GC60791 Doxepin D3 Hydrochloride

    盐酸多塞平 D3

     DoxepinD3Hydrochloride是DoxepinHydrochloride的氘代物。Doxepinhydrochloride是一种口服活性的三环抗抑郁药。Doxepinhydrochloride是一种有效的选择性组胺受体H1拮抗剂。Doxepinhydrochloride也是一种有效的CYP450抑制剂，并显着抑制CYP4502C19和CYP4501A2。
  45. GC60774 Dihydro Donepezil

    盐酸多奈哌齐二氢杂质,Dihydro E2020

     DihydroDonepezil(DihydroE2020)是Donepezil的代谢产物。Donepezil是一种有效的特异性AChE抑制剂，对bAChE和hAChE的IC50分别为8.12nM和11.6nM。
  46. GC60758 Deschloroclozapine

    氯氮平杂质

     Deschloroclozapine, a metabolite of Clozapine, is a highly potent muscarinic DREADDs (muscarinic Designer Receptors Exclusively Activated by Designer Drugs) agonist, and binds to DREADD receptor subtypes hM3Dq and hM4Di with Ki of 6.3 and 4.2 nM, respectively.
  47. GC60740 Dapoxetine-D7 hydrochloride

    LY-210448-d7 hydrochloride

     Dapoxetine-D7(LY-210448-D7)hydrochloride是Dapoxetinehydrochloride的氘代物。Dapoxetinehydrochloride是一种短效的选择性5-羟色胺再摄取抑制剂(SSRI)。
  48. GC60723 COR659 COR659是GABAB的阳性变构调节剂(PAM)。COR659可缓解大鼠对酒精和巧克力的药物成瘾。
  49. GC60709 Cinnarizine D8

    桂利嗪 D8

     An internal standard for the quantification of cinnarizine
  50. GC60691 Cetirizine Impurity C

    西替利嗪杂质C

     CetirizineImpurityC是Cetirizine的一种杂质。Cetirizine是羟嗪的羧化代谢物，是第二代抗组胺剂。Cetirizine是一种特异的、具有口服活性的H1受体(histamineH1-receptor)的长效拮抗剂。
  51. GC60662 Brexpiprazole S-oxide

    依匹哌唑硫氧化杂质,DM-3411

    BrexpiprazoleS-oxide(DM-3411)是Brexpiprazole的主要代谢产物，并通过细胞色素P4503A4(CYP3A4)代谢。Brexpiprazole是一种非典型抗精神病药，是人5-HT1A和多巴胺受体的部分激动剂，Ki分别为0.12nM和0.3nM。Brexpiprazole也是5-HT2A受体的拮抗剂，Ki为0.47nM。

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