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Home >> Signaling Pathways >> Neuroscience >> Alzheimer

Alzheimer(阿尔茨海默病)

Alzheimer

Alzheimer’s disease (AD), a neurodegenerative disorder, is the most common cause of progressive dementia. Two microscopic characteristics of AD are extracellular amyloid plaques and intracellular neurofibrillary tangles. Amyloid β peptide (Aβ), derived from amyloid precursor protein (APP) by sequential protein cleavage, and other metabolites deposit around neurons and form amyloid plaques, which contribute to the disease’s pathogenesis. The neurofibrillary tangles are formed by the aggregation of phosphorylated tau proteins. Under pathogenic conditions, tau accumulates in dendritic spines and interferes with neurotransmission. The Aβoligomer promotes tau enrichment and facilitates disease progress. read more

Products for  Alzheimer

  1. Cat.No. 产品名称 Information
  2. GC46134 Dityrosine (hydrochloride)

    Bityrosine, o,o-Ditryosine

     A neuropeptide with diverse biological activities
  3. GC45917 Leucettine L41 An inhibitor of DYRK1A, DYRK2, CLK1, and CLK3
  4. GC45831 SRI-011381 A TGF-β signaling activator
  5. GC45765 Deferiprone-d3

    去铁酮 d3

     An internal standard for the quantification of deferiprone
  6. GC45480 Histone H3K4Me3 (1-25) amide (human mouse, rat, porcine, bovine) (trifluoroacetate salt)

    ART-K(Me3)-QTARKSTGGKAPRKQLATKAA-NH2, Histone H3 (1-25) (Lys4me3), H3K4me3, Lys(Me3)4-Histone H3 (1-25) amide

    A peptide fragment of histone H3
  7. GC45378 Alaproclate (hydrochloride)

    阿拉丙酯盐酸盐

     An SSRI
  8. GC45137 Valproic Acid Acyl-D-Glucuronide

    Valproic Acid Gluclonide

     A metabolite of valproic acid
  9. GC44987 TAMRA-Amyloid-β (1-42) Peptide (trifluoroacetate salt)

    TAMRA-Aβ42, TAMRA-Aβ (1-42)

     A fluorescently labeled amyloid-β peptide
  10. GC44968 Sulfatides (bovine) (sodium salt) Sulfatides are endogenous sulfoglycolipids with various biological activities in the central and peripheral nervous systems, pancreas, and immune system.
  11. GC44674 Pramlintide (acetate hydrate)

    醋酸普兰林肽

     An amylin analog
  12. GC44416 N-methyl Mesoporphyrin IX

    N-甲基中卟啉IX

     N-methyl Mesoporphyrin IX（NMM）是卟啉的过渡态类似物，是亚铁螯合酶的有效抑制剂，Kd值为7 nM。N-methyl Mesoporphyrin IX是G-四链体的特异性染色剂，激发/发射最大值分别为399/610 nm。
  13. GC44399 NIAD-4 A fluorescent probe for Aβ
  14. GC44225 ML-345 An inhibitor of the insulin-degrading enzyme
  15. GC44131 Mca-HQKLVFFA-K(Dnp)-NH2 (trifluoroacetate salt)

    α-Secretase Fluorogenic Substrate

     A fluorogenic substrate for α-secretase
  16. GC44130 Mca-EVKMDAEF-K(Dnp)-NH2 (ammonium salt)

    β-Secretase Fluorogenic Substrate

     A fluorogenic substrate for β-secretase
  17. GC43858 Histone H3K4Me3 (1-21) (human, mouse, rat, porcine, bovine) (trifluoroacetate salt)

    ART-K(Me3)-QTARKSTGGKAPRKQLA, H3K4(Me3), Histone H3 (1-21) (Lys4me3), Lys(Me3)4-Histone H3 (1-21)

    A peptide fragment of histone H3
  18. GC43708 Fulvic Acid

    富里酸

     A fungal metabolite
  19. GC43700 FSB A fluorescent probe
  20. GC43494 DL-threo-PDMP (hydrochloride) An inhibitor of sphingolipid biosynthesis
  21. GC43322 CRANAD 28 A fluorescent affinity probe for amyloid-β
  22. GC43274 Citromycetin

    柠檬菌素

     A fungal metabolite
  23. GC42937 Biotin-Amyloid-β (1-42) Peptide (trifluoroacetate salt)

    Biotin-Aβ (1-42), Biotin-Aβ42

     An affinity probe for Aβ42 binding partners
  24. GC42803 Amyloid-β (25-35) Peptide (human) (trifluoroacetate salt)

    Aβ (25-35)

     An 11-residue amyloid-β protein fragment
  25. GC42802 Amyloid-β (1-8, A2V) Peptide

    Aβ (1-8, A2V), Aβ (1-8) mutant, Amyloid-β (1-8) dominant negative

     A truncated form of Aβ containing the A2V mutation
  26. GC42801 Amyloid-β (1-8) Peptide

    Aβ (1-8)

     A wild-type control for amyloid-β (1-8, A2V) peptide
  27. GC42796 Amylin (human) (trifluoroacetate salt)

    IAPP (human), Islet Amyloid Polypeptide (human)

     An antidiabetic peptide that forms amyloid fibrils
  28. GC42795 Amylin (human) (amidated) (trifluoroacetate salt)

    IAPP (human) (amidated), Islet Amyloid Polypeptide (human) (amidated)

     A peptide hormone
  29. GC42794 Amylin (8-37) (human) (trifluoroacetate salt)

    IAPP (8-37) (human), Islet Amyloid Polypeptide (8-37) (human)

     A peptide fragment of amylin
  30. GC42584 6-O-desmethyl Donepezil

    6-O-去甲基多奈哌齐

     An active metabolite of donepezil
  31. GC41151 Decursinol angelate Decursinol angelate is a pyranocoumarin that has been found in the Korean medicinal herb A.
  32. GC40587 8,12-iso-iPF2α-VI

    8,12-iso-Isoprostane-F2α-VI, 12-iso-5,6E,14Z-PGF2α, 125,6E,14ZProstaglandin F2α

     An isoprostane used as a biomarker for oxidative stress
  33. GC40114 Histone H3K4Me3 (1-10) (human, mouse, rat, porcine, bovine) (trifluoroacetate salt) Histone H3K4Me3 (1-10) is an N-terminal peptide fragment of histone H3 that corresponds to amino acid residues 2-11 of the human histone H3 sequence.
  34. GC40078 Memantine-d6 (hydrochloride)

    盐酸美金刚 d6 (盐酸盐)

     An internal standard for the quantification of memantine
  35. GC40068 Setosusin

    (+)-Setosusin

     A fungal metabolite
  36. GC40053 5α,6α-epoxy Cholestanol

    胆固醇-5Α,6Α-环氧化物,NSC 18176

     5α,6α-epoxy Cholestanol 是一种胆固醇衍生物，可以通过线粒体中的细胞色素P450酶系催化生成或是在脂质过氧化过程中诱导生成，可调节胆汁酸的生物合成、诱导肿瘤细胞的分化和死亡。
  37. GC40024 Altenusin

    细格菌素,Alutenusin

     A fungal metabolite with diverse biological activities
  38. GC40018 Donepezil N-oxide

    多奈哌齐N氧化物

     An active metabolite of donepezil
  39. GC19221 Leucomethylene blue Mesylate

    TRx0237 mesylate; Methylene blue leuco base mesylate

     An inhibitor of tau aggregation
  40. GC18817 3β-hydroxy-5-Cholestenoic Acid

    3β-hydroxy-5-CA, Cholesterol-26-carboxylic Acid

     An active cholesterol metabolite
  41. GC18568 JNJ-40418677 A modulator of γ-secretase
  42. GC18483 RU-505 An inhibitor of the Aβ and fibrinogen interaction
  43. GC12942 DAPT (GSI-IX)

    gamma-Secretase Inhibitor IX, DAPT, GSI-IX

     DAPT (GSI-IX) 是一种具有口服活性的 γ-分泌酶抑制剂，对人原代神经元培养物中产生的总淀粉样蛋白-β (Aβ) 和 Aβ42 的 IC50 分别为 115 nM 和 200 nM。
  44. GC12096 Semagacestat (LY450139)

    司马西特,LY-450139, LY 450139,Semagacestat

    A pan γ-secretase inhibitor
  45. GC11965 (±)-Huperzine A

    (±)-石杉碱甲

     A neuroprotective AChE inhibitor
  46. GP10094 Amyloid β-peptide (10-35), amide

    H2N-Tyr-Glu-Val-His-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Val-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-NH2

    Truncated peptide model
  47. GP10099 amyloid A protein fragment [Homo sapiens]

    H2N-Ala-Gly-Leu-Pro-Glu-Lys-Tyr-OH

    Apolipoproteins related to HDL in plasma
  48. GP10006 Myelin Basic Protein (68-82), guinea pig

    豚鼠髓磷脂碱性蛋白片段68-82,H2N-Tyr-Gly-Ser-Leu-Pro-Gln-Lys-Ser-Gln-Arg-Ser-Gln-Asp-Glu-Asn-OH

    髓鞘碱性蛋白 (68-82)，豚鼠是髓鞘碱性蛋白 (MBP) 的片段。
  49. GP10101 Beta-Sheet Breaker Peptide iAβ5

    H2N-Leu-Pro-Phe-Phe-Asp-OH

    Peptide which can inhibit amyloidogenesis
  50. GP10046 Amyloid Precursor C-Terminal Peptide

    H2N-Gly-Tyr-Glu-Asn-Pro-Thr-Tyr-Lys-Phe-Phe-Glu-Gln-Met-Gln-Asn-OH

    For beta amyloid generation
  51. GP10097 Amyloid β-Protein (1-15)

    H2N-Asp-Ala-Glu-Phe-Arg-His-Asp-Ser-Gly-Tyr-Glu-Val-His-His-Gln-OH

    淀粉样蛋白 β-蛋白 (1-15) 是 β-淀粉样蛋白肽的片段。

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