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Home >> Signaling Pathways >> Neuroscience >> CaMK

CaMK(钙调蛋白激酶)

The Ca2+/calmodulin-dependent kinase (CaMK) family has been recognized as a key mediator in living organisms and various biological processes.

Calcium/calmodulin kinase II (CaMK II) is a multifunctional cytoplasmic calcium and calmodulin-dependent protein kinase that phosphorylates and alters the function of a variety of substrates. The CaMK II pathway has been found to regulate the RANKL-induced osteoclast formation via the cAMP-response element binding protein (CREB) pathway.

Among many signaling pathways of proliferation, intracellular calciumol/L has been extensively demonstrated to be very important. In cytoplasm, calciumol/L binds to calmodulin, and then activates the Ca2+/calmodulin (CaM) dependent kinases (CaMKs) which are a family of structurally related serine/threonine protein kinases including CaMKI-IV. CaMKII, a multi functional protein kinase, is ubiquitously involved in many physiological processes including control of cell cycle, apoptosis, gene expression, and neurotransmission.

Products for  CaMK

  1. Cat.No. 产品名称 Information
  2. GC91849 Autocamtide-2-related Inhibitory Peptide (trifluoroacetate salt) Autocamtide-2-related inhibitory peptide is a calmodulin-dependent protein kinase II (CaMKII) inhibitor (IC50 = 40 nM) that was designed based on the sequence around the autophosphorylation site (Thr286/Thr287) in the autoinhibitory domain of the protein kinase.
  3. GC72206 Autocamtide-3 acetate Autocamtide-3 acetate含有Thr287的13个氨基酸的肽是选择性CaMKII（Ca2+/钙调素依赖性激酶II）（CaMK）底物。
  4. GC71066 CS587 CS587是CaMK1D的特异性抑制剂，在10μM时具有神经细胞毒性。
  5. GC71047 TIM-063 TIM-063CaMKKα和CaMKKβ的Ki值分别为0.35μM和0.2μM，IC50值分别为0.63μM和0.96μM。
  6. GC49440 ML-9

    ML-9盐酸盐

     A PKB/Akt inhibitor
  7. GC62146 XST-14 XST-14 是一种有效的，竞争性强且高度选择性的 ULK1 抑制剂，IC50 为 26.6 nM。XST-14 通过减少 ULK1 下游底物的磷酸化来诱导自噬抑制。XST-14 诱导肝细胞癌 (HCC) 细胞凋亡，并具有抗肿瘤作用。
  8. GC61521 Calmodulin-Dependent Protein Kinase II(290-309) acetate Calmodulin-DependentProteinKinaseII(290-309)acetate是有效的CaMK拮抗剂，抑制抑制Ca2+/钙调蛋白依赖性蛋白激酶II的IC50值为52nM。
  9. GC60037 A-3 hydrochloride

    赤霉酸

     A-3 hydrochloride, a potent, cell-permeable, reversible, ATP-competitive non-selective antagonist of various kinases, againsts cAMP-dependent protein kinase (PKA) (Ki=4.3 ?M), casein kinase II (CK2) (Ki=5.1 ?M) and myosin light chain kinase (MLCK) (Ki=7.4 ?M), also inhibits Protein Kinase C (PKC) and casein kinase I (CK1) with Ki values of 47 ?M and 80 ?M, respectively.
  10. GC50305 Autocamtide-2-related inhibitory peptide, myristoylated Autocamtide-2 相关抑制肽，肉豆蔻酰化是肉豆蔻酰化 Autocamtide-2 相关抑制肽。
  11. GC37710 Syntide 2 (TFA) A protein kinase substrate
  12. GC37694 STO-609 A CaMKK inhibitor
  13. GC35820 DDD107498 succinate

    DDD107498 succinate; DDD-498 succinate; M5717 succinate

     DDD107498 (M-5717, DDD-498) is a P. falciparum translation elongation factor 2 inhibitor. DDD107498 exhibits a potent and novel spectrum of antimalarial activity against multiple life-cycle stages of the Plasmodium parasite.
  14. GC35601 CaMKII-IN-1

    3-氯-2-甲基-N-[5,6,7,8-四氢-2-[(2-苯基乙基)氨基]-6-(苯基甲基)吡啶并[4,3-D]嘧啶-4-基]苯磺酰胺

     CaMKII-IN-1是CaMKII高效选择性抑制剂，IC50值为63nM,对CaMKIV, MLCK, p38a, Akt1,和PKC几乎无作用。
  15. GC35432 Autocamtide-2-related inhibitory peptide (TFA) A CaMKII inhibitor
  16. GC43128 Calmodulin-Dependent Protein Kinase II (290-309) (trifluoroacetate salt) A CaMKII inhibitor
  17. GC34390 Autocamtide 2, amide Autocamtide2,amide是钙调蛋白激酶(CaMK)家族实验的底物(100μMfinalconcentration)。
  18. GC33775 Rimacalib (SMP 114)

    SMP 114

     Rimacalib (SMP 114) (SMP 114) 是一种 Ca2+/钙调蛋白依赖性蛋白激酶 II (CaMKII) 抑制剂，IC50 为 ~1 μ；M 代表 CaMKIIα；至 ~30 μ；M 代表 CaMKIIγ；。
  19. GC33732 Syntide 2 A protein kinase substrate
  20. GC33683 Autocamtide 2 (Autocamtide II)

    Autocamtide II

     Autocamtide 2 (Autocamtide II) 是钙/钙调蛋白依赖性蛋白激酶 II (CaMKII) 的高选择性肽底物。
  21. GC31170 Calmodulin-Dependent Protein Kinase II 290-309

    A CaMKII inhibitor
  22. GC30356 Metofenazate (Methophenazine)

    美托奋乃酯,Methophenazine

     Metofenazate (Methophenazine) 是一种选择性钙调蛋白抑制剂。
  23. GC12804 KN-93 Phosphate A CaMKII inhibitor
  24. GC12739 A 484954 An eEF-2K inhibitor
  25. GC17329 MLCK inhibitor peptide 18

    MLCK抑制肽18

     A selective, cell-permeable inhibitor of MLCK
  26. GC14326 Calmidazolium chloride

    钙调蛋白抑制剂,R 24571

     An inhibitor of calmodulin
  27. GC11362 K 252a

    SF 2370

     A non-selective PKC inhibitor
  28. GC12501 KN-93 hydrochloride A selective inhibitor of Ca2+/calmodulin-dependent kinase type II
  29. GC13793 NH125 An antibacterial imidazole
  30. GC10629 KN-93

    N-[2-[N-(4-氯肉桂)-N-甲基氨基]苯基]-N-(2-羟乙基)-4-甲氧苯磺酰胺磷酸酯盐,KN 93;KN93

     Selective inhibitor of Ca2+/calmodulin-dependent kinase type II
  31. GC16981 KN-92 phosphate

    KN-92磷酸盐,KN 92 phosphate;KN92 phosphate

     KN-92 phosphate 是 KN-93 的无活性衍生物，没有 CaM 激酶抑制活性。 KN-92 磷酸盐旨在用作旨在阐明 KN-93 拮抗剂活性的研究中的对照化合物。 KN-93 是一种细胞渗透性、可逆性和竞争性 CaMKII 抑制剂。
  32. GC15988 KN-92 hydrochloride

    KN-92盐酸盐,KN 92 hydrochloride;KN92 hydrochloride

     An inactive control compound for a CaMKII inhibitor
  33. GC14132 KN-92

    KN 92;KN92

     An inactive control compound for a CaMKII inhibitor
  34. GC14202 KN-62

    1-[N,O-二(5-异喹啉磺酰基)-N-甲基-L-型酪氨酸]-4-苯基哌嗪

     Inhibitor of Ca2+/calmodulin-dependent kinase type II

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