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Home >> Signaling Pathways >> Neuroscience >> COX

COX(环氧合酶)

COX (cyclooxygenase) is an enzyme that is responsible for formation of important biological mediators called prostanoids, including prostaglandins, prostacyclin and thromboxane.

Products for  COX

  1. Cat.No. 产品名称 Information
  2. GC61689 Alminoprofen

    阿明洛芬,EB-382

     Alminoprofen是苯丙酸类非甾体抗炎药(NSAID)。Alminoprofen同时具有抑制分泌磷脂酶A2(sPLA2)活性和抗环氧化酶(COX-2)的活性。
  3. GC61436 Gallic acid hydrate

    没食子酸-水合物; 3,4,5-Trihydroxybenzoic acid hydrate

     A phenol with diverse biological activities
  4. GC19706 Propacetamol hydrochloride

    盐酸丙帕他莫

     A prodrug form of acetaminophen
  5. GC48858 APHS A COX inhibitor
  6. GC48827 Flufenamic Acid-d4

    FFA-d4, Fluphenamic Acid-d4

     An internal standard for the quantification of flufenamic acid
  7. GC48677 Sulindac-d3

    MK-231-d3

     An internal standard for the quantification of sulindac
  8. GC48639 Lornoxicam-d4

    氯诺昔康-D4,Chlortenoxicam-d4; Ro 13-9297-d4

     An internal standard for the quantification of lornoxicam
  9. GC48232 Valdecoxib-d3

    戊地昔布-D3,SC 65872-d3

     An internal standard for the quantification of valdecoxib
  10. GC47734 Nabumetone-d3

    萘丁美酮-D3,BRL14777-d3

     An internal standard for the quantification of nabumetone
  11. GC47639 Metamizole-d3 (sodium salt)

    Dipyrone-d3

     A neuropeptide with diverse biological activities
  12. GC47528 Ketorolac (calcium salt)

    酮咯酸钙盐,RS37619 hemicalcium

     An NSAID and COX inhibitor
  13. GC47287 Eltenac

    依尔替酸

     A non-selective COX inhibitor
  14. GC47213 Diclofenac-d4

    双氯芬酸 D4

     An internal standard for the quantification of diclofenac
  15. GC47212 Diclofenac amide

    1-(2,6-二氯苯基)-1,3-二氢-2H-吲哚-2-酮

     A prodrug form of diclofenac
  16. GC47070 Celecoxib-d7

    塞来昔布-D7,SC 58635-d7

     An internal standard for the quantification of celecoxib
  17. GC46781 Acetaminophen-d4

    对乙酰氨基酚 d4

     An internal standard for the quantification of acetaminophen
  18. GC46290 (±)-Ibuprofen-d3

    氘代布洛芬,(±)-Ibuprofen-d3

     An Analytical Reference Standard
  19. GC61371 Veratric acid

    藜芦酸

     Veratricacid(3,4-Dimethoxybenzoicacid)是从蔬菜和水果中得到的多酚物质，可口服，具有抗氧化、保护心血管和抗炎活性。当细胞受到UVB辐射时，Veratricacid能够减少上调的COX-2表达，降低PGE2和IL-6水平。
  20. GC61337 Tolmetin

    托麦汀；托美丁

     Tolmetin (Tolectin) is a nonsteroidal anti-inflammatory drug of the heterocyclic acetic acid derivative class and also exhibits analgesic and antipyretic activity.
  21. GC61238 Rehmapicrogenin

    地黄苦苷元

    Rehmapicrogenin可从Rehmanniaglutinosa的根部分离得到，通过抑制iNOS、COX-2和IL-6表现出有效的抗炎作用。
  22. GC61235 Regaloside B

    王百合苷 B

     RegalosideB是一种从Liliumlongiflorum中分离出来的苯丙烷。RegalosideB可以抑制iNOS和COX-2的表达，具有抗炎活性。
  23. GC61234 Rebamipide D4

    瑞巴派特 D4; OPC12759-d4; Proamipide-d4

     An internal standard for the quantification of rebamipide
  24. GC61193 Piroxicam D3

    吡罗昔康 D3; CP-16171 D3

     An internal standard for the quantification of piroxicam
  25. GC61180 Phenidone

    菲尼酮

     Phenidone (1-phenyl-3-pyrazolidinone), a dual inhibitor of cyclooxygenase (COX) and lipoxygenase (LOX), is an organic compound that is primarily used as a photographic developer.
  26. GC61038 Mefenamic acid D4

    甲芬那酸 D4

     An internal standard for the quantification of mefenamic acid
  27. GC60966 Ketorolac D5

    酮咯酸D5

     An internal standard for the quantification of ketorolac
  28. GC60935 Indomethacin sodium hydrate

    吲哚美辛钠盐三水合物; Indometacin sodium hydrate

     A non-selective COX inhibitor
  29. GC60926 Ibuprofen impurity 1

    布洛芬杂质

     Ibuprofenimpurity1是Ibuprofen的杂质。Ibuprofen是COX-1和COX-2的抑制剂，IC50值分别为13μM和370μM，具有抗炎的活性。
  30. GC60523 4-Methylamino antipyrine hydrochloride

    安乃近杂质C

     An active metabolite of metamizole
  31. GC60447 1-Hydroxy-ibuprofen

    1-羟基异丁基苯基-1'-甲基丙酸

     1-hydroxy Ibuprofen 是非甾体类抗炎药 (NSAID) 和非选择性 COX 抑制剂布洛芬的代谢物。
  32. GC60345 Sphondin

    牛防风素

     Sphondin可从Heracleumlaciniatum中分离，对IL-1β诱导的A549细胞中COX-2蛋白和PGE2释放水平的升高具有抑制作用。
  33. GC60311 PTUPB PTUPB是一种新型的COX-2和sEH双抑制剂，IC50 值分别为 1.26 nM 和 0.9μM。
  34. GC60283 Pentagamavunon-1

    PGV-1

     Pentagamavunon-1 (PGV-1) 是Curcumin 的类似物，具有口服活性，通过多个机制诱导凋亡信号，如抑制COX-2 和 VEGF。Pentagamavunon-1 (PGV-1) 可抑制 NF-κB 的激活。
  35. GC60228 Loxoprofen sodium

    洛索洛芬钠

     An NSAID and a prodrug form of loxoprofen-SRS
  36. GC60225 Licarin A

    利卡灵A,(+)-Licarin A

     LicarinA((+)-LicarinA)，可从多种植物中分离得到，显着降低二硝基苯肼-人血清白蛋白(DNP-HSA)刺激的RBL-2H3细胞。具有抗过敏作用。LicarinA降低TNF-α和PGD2产生，和COX-2表达。
  37. GC39583 Nimesulide D5

    尼美舒利 D5

     An internal standard for the quantification of nimesulide
  38. GC39534 Isoxicam

    伊索昔康

     Isoxicam 是一种口服有效的非甾体抗炎剂，可用于关节炎的研究。Isoxicam 是一种非选择性的 COX-1 和 COX-2 抑制剂。
  39. GC39307 4-Methylamino antipyrine

    4-(甲氨基)安替比林

     An active metabolite of metamizole
  40. GC39134 Isofraxidin

    异嗪皮啶

     Isofraxidin (6,8-Dimethoxyumbelliferone), a bioactive coumarin compound isolated from the functional foods Siberian ginseng and Apium graveolens, is an anti-bacterial, anti-oxidant, and anti-inflammatory agent.
  41. GC39040 Taraxerol acetate

    醋酸蒲公英霜

     Taraxerol acetate 是 COX-1 和 COX-2 抑制剂， IC50 值分别为 116.3 μM 和 94.7μM。Taraxerol acetate 具有抗癌作用并诱导细胞凋亡(apoptosis)。
  42. GC39013 FPL 62064

    N-(4-甲氧苯基)-1-苯基-1H-吡唑-3-胺

     FPL 62064 is a potent dual inhibitor of 5-lipoxygenase (5-LOX) and prostaglandin synthetase (cyclooxygenase, COX) with IC50 of 3.5 μM and 3.1 μM for RBL-1 cytosolic 5-lipoxygenase and seminal vesicle prostaglandin synthetase, respectively. FPL 62064 has potent anti-inflammatory activity.
  43. GC45965 Tolfenamic Acid-d4

    托芬那酸 D4

     An internal standard for the quantification of tolfenamic acid
  44. GC45823 Rofecoxib-d5

    罗非考昔 d5

     An internal standard for the quantification of rofecoxib
  45. GC45820 Balsalazide-d4 Balsalazide-d4 是氘标记的 Balsalazide。
  46. GC38678 Ethyl Caffeate

    咖啡酸乙酯

     Ethyl caffeate, a naturally occurring compound found in Bidens pilosa, suppresses NF-kappaB activation and its downstream inflammatory mediators, iNOS, COX-2 and PGE2 in vitro.
  47. GC38616 Hamaudol

    亥茅酚

     Hamaudol 是从 Saposhnikovia divaricata 中分离出的一种色酮。Hamaudol 对环加氧酶 (COX)-1 和 COX-2 的活性具有明显的抑制能力，其 IC50 值分别为 0.30、0.57 mM，并且具有有效的镇痛和抗炎作用。
  48. GC38431 Dehydroevodiamine

    脱氢吴茱萸碱

     An alkaloid with diverse biological activities
  49. GC38224 Crocin II

    西红花苷II

     Crocin II (Crocin B, Crocetin gentiobiosylglucosyl ester, Tricrocin), a carotenoid chemical compound that is found in the flowers crocus and gardenia, is an antioxidant and neural protective agent.
  50. GC38198 Revaprazan hydrochloride

    盐酸瑞伐拉赞

     Revaprazan Hydrochloride (YH1885) is a new reversible proton pump inhibitor with long-lasting acid-suppressive effects. Revaprazan Hydrochloride reversibly inhibits H(+)/K(+)-ATPase via binding to the K+-binding site of the pump.
  51. GC38184 Dehydrodiisoeugenol

    脱氢二异丁香酚

     Dehydrodiisoeugenol, a naturally occurring lignan from Aristolochia taliscana (Aristolochiaceae), acts as a potent anti-inflammatory agent and shows various pharmacological activities, including anti-lipid peroxidation, anti-bacteial function, and hepatic drug metabolism enzyme inhibition.

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