COX(环氧合酶)

Cat.No. 产品名称 Information

GC38151 Roburic acid

栎樱酸

Roburic acid 是秦艽中的四环三萜类化合物，作为一种 COX 的抑制剂，对 COX-1 和 COX-2 的 IC50 值分别为 5 和 9 μM。

GC38066 Mavacoxib

吗伐考昔

Mavacoxib (Trocoxil) is a selective, long-acting cyclooxygenase-2 (COX-2) inhibitor. Mavacoxib is a novel nonsteroidal anti-inflammatory drug (NSAID).

GC45579 Tiaprofenic Acid

噻洛芬酸

A COX inhibitor and NSAID

GC45278 (±)-Ketoprofen-d3

酮洛芬D3,RP-19583-d3

An internal standard for the quantification of (±)-ketoprofen

GC36852 Parecoxib

帕瑞昔布; SC 69124

A prodrug form of valdecoxib

GC36828 Oxaprozin D4

Wy-21743 D4

Oxaprozin D4是Oxaprozin的氘代化合物标准品。

GC36747 Nitroaspirin

2-乙酰氧基苯甲酸-3-硝酸甲基苯酯,NCX 4016

Nitroaspirin (NCX 4016) 是一氧化氮 (NO) 供体和阿司匹林的硝基衍生物，Aspirin 与 Nitroaspirin 联合以抑制环加氧酶。Nitroaspirin (NCX 4016) 具有抗血栓形成和抗血小板特性，并作为 COX-1 的直接和不可逆抑制剂。Nitroaspirin (NCX 4016) 通过下调 EGFR/PI3K/STAT3 信号传导和调节 Bcl-2 家族蛋白，在顺铂耐药人卵巢癌细胞中引起细胞周期停滞和凋亡。

GC36721 Nepafenac D5

奈帕芬胺 D5; AHR-9434-d5; AL-6515-d5

An internal standard for the quantification of nepafenac

GC36482 Loxoprofen

洛索洛芬

An NSAID and a prodrug form of loxoprofen-SRS

GC36314 Indobufen

吲哚布芬; Ibustrin

Indobufen (Ibustrin, K 3920) is a reversible platelet aggregation inhibitor. Indobufen is a reversible inhibitor of platelet cyclooxygenase (Cox) activity and suppresses thromboxane synthesis.

GC36305 Imrecoxib

艾瑞昔布; BAP-909

Imrecoxib（BAP-909）艾瑞昔布是选择性环氧合酶 2 (COX-2) 抑制剂，IC50 值为 18 nM，也可以抑制 COX1 活性，IC50 值为 115 nM。Imrecoxib（BAP-909) 艾瑞昔布具有抗炎作用。

GC36200 GW-406381

GW406381X

A NSAID and COX-2 inhibitor

GC36014 Etoricoxib D4

依托考昔 D4; MK-0663-d4; L-791456-d4

Etoricoxib D4 (MK-0663 D4) 是 Etoricoxib 的氘代标记物。Etoricoxib 是一种非甾体抗炎剂，为可口服的、选择性的 COX-2 抑制剂，对人全血 COX-2 和 COX-1 的 IC50 值分别为 1.1 μM 和 116 μM。

GC35493 Benzoylgomisin O

苯甲酰戈米辛O

Benzoylgomisin O 是从 Schisandra rubriflora 中分离的化合物，对 15-LOX、COX-1、COX-2 酶有抑制作用，且具有抗炎活性。

GC35013 [8]-Shogaol

8-姜烯酚

[8]-Shogaol，生姜中的一种刺激性酚类化合物，具有抗血小板活性 (IC50=5 μM) 和抑制 COX-2 (IC50=17.5 μM)。[8]-Shogaol 诱导人白血病细胞凋亡。

GC35012 [10]-Shogaol

10-姜烯酚

A phenol with diverse biological activities

GC44597 Peonidin (chloride)

氯化芍药素,YGM-6 chloride

A plant pigment with antioxidant properties

GC44439 NO-Indomethacin

NCX 2121

An NSAID-NO donor hybrid with anti-cancer activity

GC44167 Metamizole (sodium salt)

安乃近

A nonopioid prodrug

GC43635 Ethyl p-methoxycinnamate

对甲氧基肉桂酸乙酯

A natural product with diverse actions

GC43447 Diclofenac methyl ester

双氯酚甲酯

A prodrug form of diclofenac

GC43149 CAY10404 A COX-2 inhibitor

GC42859 Aspirin-d4

阿司匹林D4,Acetylsalicylic Acid-d4; ASA-d4

An internal standard for the quantification of aspirin

GC42692 Aceclofenac methyl ester

Aceclofenac Impurity D

A potential impurity in commercial preparations of aceclofenac

GC42691 Aceclofenac ethyl ester A potential impurity found in commercial preparations of aceclofenac

GC42201 3,3'-Diiodo-L-thyronine

3,3'-二碘甲腺原氨酸,3,3'-T2

A metabolite of thyroid hormone

GC41761 1-(6-Methoxy-2-naphthyl)ethanol

DL-6-甲氧基-ALPHA-甲基-2-萘甲醇

A potential impurity found in commercial naproxen preparations

GC41658 (±)-2-hydroxy Ibuprofen

2-羟基布洛芬; (±)-2-Hydroxy Ibuprofen

A metabolite of ibuprofen

GC41645 Jacaric Acid

8(Z),10(E),12(Z)-Octadecatrienoic Acid

A conjugated PUFA

GC41634 Metyrosine

甲酪氨酸

An inhibitor of tyrosine hydroxylase

GC41623 β-Elemonic Acid

β-岚香酮酸

A triterpene with anticancer activity

GC41396 Heneicosapentaenoic Acid

HPA

A 21:5 ω-3 fatty acid

GC41389 (S)-Ketorolac

(1S)-5-苯基-2,3-二氢-1H-吡啶-1-羧酸,(-)-Ketorolac

A non-selective COX inhibitor

GC41218 Guaiacol Guaiacol is a phenolic natural product first isolated from Guaiac resin and the oxidation of lignin.

GC40842 (-)-Catechin

(-)-儿茶素; (-)-Cianidanol; (-)-Catechuic acid

A diastereoisomer of catechin

GC40686 N-trans-Feruloyltyramine

N-反式-阿魏酰酪胺,N-feruloyltyramine; Moupinamide

A phenolic amide with diverse biological activities

GC40651 Oxyphenbutazone

羟布宗

An NSAID

GC40565 Feprazone

非普拉宗,DA2370; Prenazone; Zepelin

A COX-2 inhibitor

GC40352 Cafestol

咖啡醇

A natural diterpene which increases serum cholesterol

GC40262 α-Humulene

ALPHA-律草烯,Humulene; α-Caryophyllene

A sesquiterpene with diverse biological activities

GC40227 Indomethacin-d4

吲哚美辛-D4; Indometacin-d4

An internal standard for the quantification of indomethacin

GC40065 Meloxicam-d3

美洛昔康 d3

An internal standard for the quantification of meloxicam

GC34116 Hexahydrocurcumin

六氢姜黄素

A natural product and an active metabolite of curcumin

GC34028 Nitroflurbiprofen (HCT 1206)

硝基氟比洛芬; HCT 1206; NO-flurbiprofen; Nitroxybutyl flurbiprofen

Nitroflurbiprofen (HCT 1206) 是一种环氧合酶 (COX) 抑制剂，具有提供一氧化氮 (NO) 的特性，可调节门脉高压性肝硬化大鼠肝内血管张力的增加。

GC33893 FR-188582 FR-188582是高选择性的环氧合酶(COX-2)抑制剂，IC50值为17nM。

GC33876 Propyphenazone (4-Isopropylantipyrine)

异丙安替比林; 4-Isopropylantipyrine; Isopropylphenazone

Propyphenazone(4-Isopropylantipyrine, Isopropyrine), an analgesic and antipyretic agent, is a selective cyclooxygenase-2 inhibitor with anti-inflammatory activity.

GC33861 Inulicin (1-O-Acetylbritannilactone)

旋覆花内酯,1-O-Acetylbritannilactone

A sesquiterpene lactone with diverse biological activities

GC33632 Veratric acid (3,4-Dimethoxybenzoic acid)

藜芦酸; 3,4-Dimethoxybenzoic acid

Veratric acid (3,4-Dimethoxybenzoic acid), a simple benzoic acid derived from plants and fruits, has anti-oxidant, anti-inflammation, and blood pressure-lowering effects. Veratric acid reduces upregulated COX-2 expression, and levels of PGE2, IL-6 after UVB irradiation.

GC33484 Ampyrone (4-Aminoantipyrine)

4-氨基安替比林

4-Aminoantipyrine(Ampyrone) is a metabolite of aminopyrine with analgesic, anti-inflammatory, and antipyretic properties. It is used as a reagent for biochemical reactions producing peroxides or phenols.

GC32957 (-)-Catechin gallate ((-)-Catechin 3-gallate)

儿茶素没食子酸酯; (-)-Catechin 3-gallate; (-)-Catechin 3-O-gallate

A polyphenol with diverse biological activities

COX(环氧合酶)

Products for COX