GABA Receptor(γ-氨基丁酸受体)

Cat.No. 产品名称 Information

GC50375 PZ-II-029 α6β3γ2-selective GABAA positive allosteric modulator

GC50198 Topiramate - d12

托吡酯-D12,McN 4853 D12 ; RWJ 17021 D12

An internal standard for the quantification of topiramate

GC39126 Thiocolchicoside

硫秋水仙苷

A GABA_A receptor antagonist

GC45961 THDOC

3ALPHA,21-二羟基-5ALPHA-孕甾-20-酮,THDOC

A neurosteroid and positive allosteric modulator of GABA_A receptors

GC38758 Clomethiazole

氯美噻唑

Chlormethiazole 是一种有效的口服 GABAA 激动剂。 Chlormethiazole 还可以抑制人肝微粒体中的细胞色素 P450 亚型: CYP2A6 和 CYP2E1。Chlormethiazole 有抗惊厥作用，具有治疗惊厥性癫痫的潜力。

GC38677 (-)-α-Pinene

β-蒎烯; (-)-β-Pinene

(-)-α-Pinene 是一种单萜类化合物，通过在 BZD 结合位点作为部分调节剂与 GABAA-苯二氮卓 (BZD) 受体直接结合，显示出增强睡眠的特性。

GC38387 CP-409092 hydrochloride CP-409092 hydrochloride 是 GABAA 受体的部分激动剂，具有抗焦虑活性。

GC38010 γ-Aminobutyric acid

γ-氨基丁酸

4-Aminobutyric acid (4-Aminobutanoic acid, GABA, Gamma-aminobutyric acid, Piperidic acid) is a naturally occurring neurotransmitter with central nervous system (CNS) inhibitory activity.

GC37905 Vigabatrin

氨己烯酸; γ-Vinyl-GABA

Inhibitor of GABA transaminase

GC37788 Tiagabine hydrochloride hydrate

噻加宾盐酸水合物; NO050328 hydrochloride hydrate; NO328 hydrochloride hydrate; TGB hydrochloride hydrate

A GAT-1 inhibitor

GC37784 THIP

加波沙朵,Gaboxadol

THIP (Gaboxadol) 是一种选择性 δ-GABAAR 激动剂，功能选择性 GABAAR 配体，对 α4β1δ, α4β3δ 表现出激动作用，对 αβγ 和 α4β2δ GABAARs 表现出弱拮抗作用。

GC37547 Ro 41-3290 Ro 41-3290 是一种催眠剂，是 Ro 41-3696 的去甲基化衍生物。Ro 41-3696 是一种苯二氮卓类 (benzodiazepine) 受体的部分激动剂。

GC36058 Flumazenil acid

4H-咪唑并[1,5-A][1,4]苯并二氮杂环庚烷-3-甲酸,8-氟-5,6-二氢-5-甲基-6-氧代-,Ro 15-3890

Flumazenil acid 是 Flumazenil 的一种代谢产物。Flumazenil 是一种 GABAA 受体拮抗剂。

GC36012 Etifoxine

艾替伏辛,HOE 36-801

A positive allosteric modulator of GABA_A receptors

GC35975 Emamectin Benzoate

甲胺基阿维菌素苯甲酸盐; MK-244

Emamectin Benzoate (EMB, MK-244) activates gamma-amino butyric acid (GABA) transporter. Emamectin Benzoate induces of reactive oxygen species (ROS)-mediated DNA damage and apoptosis.

GC35669 CGP 36742

SGS-742

A GABA_B receptor antagonist

GC34986 (R)-Baclofen hydrochloride

(R)-巴氯芬盐酸盐; Arbaclofen hydrochloride; STX 209 hydrochloride

A GABA_B receptor agonist

GC34954 (+)-Borneol

(+)-冰片

A bicyclic monoterpene with diverse biological activities

GC44841 Riluzole (hydrochloride)

PK 26124 hydrochloride

An inhibitor of glutamatergic transmission

GC44040 LAU159 A positive allosteric modulator of α6β3γ2 subunit-containing GABAA receptors

GC43261 Cholesteryl Myristate

胆固醇肉豆蔻酸; Cholesteryl myristate; Cholesteryl tetradecanoate

A cholesterol ester

GC41613 Valnoctamide

戊诺酰胺,Valmethamide

An anxiolytic that suppresses seizures

GC34494 Bifenazate

联苯肼酯

An acaricide

GC34362 SSD114 hydrochloride SSD114hydrochloride是一种新型GABAB受体正变构调节剂。

GC34064 Aminooxyacetic acid hemihydrochloride (Carboxymethoxylamine Hemihydrochloride)

氨氧基乙酸半盐酸盐; Carboxymethoxylamine hemihydrochloride; Aminooxyacetate hemihydrochloride

A GABA-T inhibitor

GC33754 FG8119 (NNC13-8119)

NNC13-8119

FG8119 (NNC13-8119) 是一种从美国专利 4745112 A 中提取的新型苯二氮卓类激动剂。

GC33751 CGP11952 CGP11952是一种三唑基Benzaphenon。CGP11952是一种苯二氮卓类(benzodiazepine)衍生物。

GC33703 3,4,5-Trimethoxycinnamic acid

3,4,5-三甲氧基肉桂酸

3,4,5-Trimethoxycinnamic acid (TMCA) is one of the constituents of Polygalae Radix and may exert anti-seizure activity by acting at the GABAA/BZ receptor complex.

GC33504 4-Acetamidobutanoic acid (N-acetyl GABA)

4-乙酰氨基丁酸,N-acetyl GABA

A GABA derivative

GC31990 Bamaluzole

巴马鲁唑

Bamaluzole是一个GABA受体激动剂，来自专利WO2012064642A1。

GC31282 p-Hydroxybenzaldehyde

对羟基苯甲醛

p-Hydroxybenzaldehyde (4-Hydroxybenzaldehyde, 4-Formylphenol, p-Formylphenol), which can be found in the orchids Gastrodia elata, Galeola faberi and vanilla, is a hydroxybenzaldehyde that reacts with NAD+ and H2O to produce 4-hydroxybenzoate, NADH, and 2 protons. p-Hydroxybenzaldehyde at 101.7 μM can significantly reduce the GABA-induced chloride current of GABAA receptors(α1β2γ2S subtype) expressed.