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Home >> Signaling Pathways >> Neuroscience >> Serotonin Transporter

Serotonin Transporter(血清素转运蛋白)

Serotonin Transporters (SERTs) are integral membrane proteins that transport serotonin from synaptic spaces into presynaptic neurons. SERTs function by reuptaking serotonin in the synaptic cleft, effectively terminating the function of serotonin and halting neuronal transmission. Serotonin reuptake is a critical process to prevent overstimulation of nerves.

Serotonin transporter (SERT) regulates extracellular levels of serotonin (5-hydroxytryptamine, 5HT) in the brain by transporting 5HT into neurons and glial cells. The human SERT (hSERT) is the primary target for drugs used in the treatment of emotional disorders, including depression. hSERT belongs to the solute carrier 6 family that includes a bacterial leucine transporter (LeuT), for which a high resolution crystal structure has become available.

Products for  Serotonin Transporter

  1. Cat.No. 产品名称 Information
  2. GC71620 Venlafaxine-d6 Venlafaxine-d6是氘标记的文拉法辛。
  3. GC71618 rel-Sertraline-d3 hydrochloride rel-Sertraline-d3 hydrochloride是氘标记的盐酸舍曲林。
  4. GC70271 Ampreloxetine hydrochloride Ampreloxetine hydrochloride是去甲肾上腺素转运蛋白（NET）和血清素5-HT摄取转运蛋白（SERT）的口服活性和中枢神经系统渗透抑制剂，但不是多巴胺转运蛋白（DAT）。
  5. GC70178 ZZL-7 ZZL-7 是一种速效抗抑郁剂。ZZL-7 通过破坏中缝背核 (DRN) 中的血清素转运体 (SERT) 和神经元一氧化氮合酶 (nNOS) 之间的相互作用起作用。ZZL-7 可以轻松穿过血脑屏障，并可用于重度抑郁症 (MDD) 的研究。
  6. GC69880 SERT-IN-2 SERT-IN-2 是一种强效 SERT 抑制剂 (IC50=0.58 nM)，具有抗抑郁活性。SERT-IN-2 的生物利用度好，在大鼠中 F(%) 为 83.28%。SERT-IN-2 能够透过血脑屏障。
  7. GC25708 Paroxetine mesylate

    BRL-29060A mesylate,FG-7051 mesylate

     Paroxetine Mesylate(BRL-29060A mesylate,FG-7051 mesylate) is the mesylate salt form of paroxetine, a phenylpiperidine derivative and a selective serotonin reuptake inhibitor (SSRI) with antidepressant and anxiolytic properties.
  8. GC65209 Imipramine-d4 hydrochloride

    盐酸丙咪嗪 d4 (盐酸盐)

     Imipramine-d4 hydrochloride 是 Imipramine hydrochloride 的氘代物。Imipramine hydrochloride 抑制血清素转运蛋白(serotonin)，IC50 值为 32 nM。Imipramine hydrochloride 可阻止胰酶的易位，抑制 MV 和外泌体的分泌。
  9. GC65014 DSP-1053 DSP-1053 是一种苄基哌啶衍生物，一种有效的血清素转运蛋白 (SERT) 抑制剂，Ki 值为 1.02 nM。DSP-1053 显示部分 5-HT1A 受体激动活性，Ki 值为 5.05 nM。DSP-1053 具有抗抑郁活性。
  10. GC48255 Vortioxetine-d8

    Lu AA 21004 D8

     An internal standard for the quantification of vortioxetine
  11. GC47277 Duloxetine-d3 (hydrochloride)

    (Rac)-Duloxetine-d3 hydrochloride

     An internal standard for the quantification of duloxetine
  12. GC47101 Clomipramine-d3 (hydrochloride)

    盐酸氯米帕明-D3,Chlorimipramine-d3 hydrochloride; G-34586-d3 hydrochloride; NSC-169865-d3 hydrochloride

     An Analytical Reference Standard
  13. GC60740 Dapoxetine-D7 hydrochloride

    LY-210448-d7 hydrochloride

     Dapoxetine-D7(LY-210448-D7)hydrochloride是Dapoxetinehydrochloride的氘代物。Dapoxetinehydrochloride是一种短效的选择性5-羟色胺再摄取抑制剂(SSRI)。
  14. GC60424 (S)-Venlafaxine

    文拉法辛S-异构体

     (S)-Venlafaxine是Venlafaxine的S构型化合物。Venlafaxine是口服有效的5-羟色胺(5-HT)/去甲肾上腺素(NE)重摄取的双重抑制剂。Venlafaxine具有抗抑郁作用。
  15. GC60394 (±)-Duloxetine hydrochloride

    (Rac)-Duloxetine hydrochloride

     (±)-Duloxetine((Rac)-Duloxetine)hydrochloride是Duloxetinehydrochloride的外消旋体。Duloxetinehydrochloride是一种5-羟色胺去甲肾上腺素再摄取抑制剂，可用于糖尿病性神经痛和纤维肌痛以及抑郁症的研究。
  16. GC18497 Dapoxetine hydrochloride

    达泊西汀,(S)-(+)-Dapoxetine; LY-210448

     An Analytical Reference Standard
  17. GC37906 Vilazodone D8

    盐酸维拉佐酮 d8

     An internal standard for the quantification of vilazodone
  18. GC35444 Azaphen dihydrochloride monohydrate

    5-甲基-3-(4-甲基-1-哌嗪基)-5H-哒嗪并[3,4-B][1,4]苯并恶嗪二盐酸盐一水合物,Azafen dihydrochloride monohydrate; Pipofezin dihydrochloride monohydrate; Pipofezine dihydrochloride monohydrate; Azaphenonxazine dihydrochloride monohydrate

     Pipofezine(Azafen，Azaphen)是5-羟色胺重吸收抑制剂。
  19. GC35443 Azaphen

    阿扎吩,Azafen; Pipofezin hydrochloride; Pipofezine hydrochloride

     Pipofezine(Azafen,Azaphen)是5-羟色胺重吸收抑制剂。
  20. GC44057 Levomilnacipran (hydrochloride)

    左旋米那普林盐酸盐,Levomilnacipran hydrochloride; F-2695 hydrochloride

     A serotonin and norepinephrine reuptake inhibitor
  21. GC34575 Eplivanserin mixture

    SR-46349 (mixture)

     Eplivanserinmixture是一种选择性的血清素再摄取抑制剂，是5-HT2A受体的拮抗剂。化合物信息来自专利WO2005/002578A1。
  22. GC34559 DOV-216,303 Free Base

    1-(3,4-二氯苯基)-3-氮杂双环[3.1.0]己烷

     DOV-216,303(FreeBase)是有效的5-羟色胺、去甲肾上腺素、多巴胺再摄取的三重抑制剂，其对hSERT、hNET和hDAT的IC50值分别为14nM，20nM和78nM。在嗅球切除大鼠模型中，可增加前额皮质中单胺的释放及具有抗抑郁的作用。
  23. GC33715 Fluoxetine (LY-110140)

    氟西汀; LY-110140 free base

     氟西汀Fluoxetine (LY-110140)是一种具有口服活性的选择性5-羟色胺再摄取抑制剂（SSRI），常用于治疗抑郁症、强迫症、恐慌症等多种精神疾病。
  24. GC31283 Centanafadine (EB-1020)

    (1R,5S)-1-(2-萘基)-3-氮杂双环[3.1.0]己烷,EB-1020

     Centanafadine (EB-1020) 是双重去甲肾上腺素 (NE)/多巴胺 (DA) 转运蛋白抑制剂，也抑制血清素转运蛋白，对人 NE、DA 和血清素转运蛋白的 IC50 分别为 6 nM、38 nM 和 83 nM。
  25. GC31175 Centanafadine hydrochloride (EB-1020 (hydrochloride))

    EB-1020 hydrochloride

     Centanafadine (hydrochloride) 是去甲肾上腺素 (NE)/多巴胺 (DA) 转运蛋白双重抑制剂，也抑制血清素转运蛋白，对人 NE、DA 和血清素转运蛋白的 IC50 分别为 6 nM、38 nM 和 83 nM。
  26. GC31064 Duloxetine ((S)-Duloxetine)

    度洛西汀; (S)-Duloxetine; LY248686

     Duloxetine (LY-248686) is a potent inhibitor of serotonin (5-hydroxytryptamine, 5-HT) and noradrenaline (NE) uptake in vitro and in vivo and is 3- to 5-times more effective at inhibiting 5-HT uptake.
  27. GC31041 Wf-516 Wf-516是一种5-HTreuptake的抑制剂，同时为5-HT1A和5-HT2A受体拮抗剂，对人体5-HT1A和5-HT2A受体的Ki值分别为5nM和40nM，具有抗抑郁作用。
  28. GC31029 Nitroxazepine (CIBA 2330Go)

    CIBA 2330Go

     Nitroxazepine (CIBA 2330Go) 是一种用于抑郁症研究的三环类抗抑郁药 (TCA)。
  29. GC31020 SPD-473 citrate SPD-473citrate是5-HT/多巴胺/去甲肾上腺素再摄取抑制剂。
  30. GC30992 Paroxetine hydrochloride hemihydrate (BRL29060 hydrochloride hemihydrate)

    盐酸帕罗西汀半水合物; BRL29060 hydrochloride hemihydrate; BRL29060A hemihydrate

     Paroxetine HCl (BRL-29060A, FG-7051) is an antidepressant drug of the SSRI type.
  31. GC30981 Amitifadine hydrochloride (DOV-21947 hydrochloride)

    DOV-21947 hydrochloride; EB-1010 hydrochloride

    Amitifadine hydrochloride (DOV-21947 hydrochloride) 是一种 5-羟色胺-去甲肾上腺素-多巴胺再摄取抑制剂 (SNDRI)，在 HEK 293 细胞中对 5-羟色胺、去甲肾上腺素和多巴胺的 IC50 分别为 12、23、96 nM。
  32. GC30772 Dopamine serotonin antagonist-1

    氯氮平杂质,Deschloroclozapine

     Deschloroclozapine, a metabolite of Clozapine, is a highly potent muscarinic DREADDs (muscarinic Designer Receptors Exclusively Activated by Designer Drugs) agonist, and binds to DREADD receptor subtypes hM3Dq and hM4Di with Ki of 6.3 and 4.2 nM, respectively.
  33. GC30375 Clomipramine D3

    Chlorimipramine-d3; G-34586-d3; NSC-169865-d3

     An Analytical Reference Standard
  34. GC19118 Dasotraline hydrochloride

    达索曲林盐酸盐,SEP-225289 hydrochloride

     Dasotraline hydrochloride (SEP-225289 hydrochloride) 是一种三重再摄取抑制剂，可阻断多巴胺、去甲肾上腺素和血清素转运蛋白，IC50 值分别为 4、6 和 11 nM。
  35. GC19117 Dasotraline

    SEP 225289

     Dasotraline 是一种三重再摄取抑制剂，可阻断多巴胺、去甲肾上腺素和血清素转运蛋白，IC50 值分别为 4、6 和 11 nM。
  36. GC12885 Imipramine (hydrochloride)

    盐酸丙咪嗪

     A tricyclic antidepressant
  37. GC14035 Citalopram hydrobromide

    氢溴酸西酞普兰; (±)-Citalopram hydrobromide; Lu 10-171

     A selective serotonin reuptake inhibitor
  38. GC10126 Desipramine hydrochloride

    盐酸去甲咪嗪；盐酸地昔帕明

     Desipramine hydrochloride 是去甲肾上腺素转运蛋白 (NET)、5-HT 转运蛋白 (SERT) 和多巴胺转运蛋白 (DAT) 的抑制剂，Kis 分别为 4、61 和 78,720 nM。
  39. GC11798 Cinchonidine

    辛可尼定; α-Quinidine

     Cinchonidine (α-Quinidine) 是一种金鸡纳生物碱，存在于金鸡纳 (Cinchona officinalis) 和 Gongronema latifolium 中。
  40. GC17061 Dapoxetine HCl

    盐酸达泊西汀; LY-210448 hydrochloride

     An Analytical Reference Standard
  41. GC15107 Clomipramine HCl

    盐酸氯米帕明; Chlorimipramine hydrochloride; G-34586 hydrochloride; NSC-169865 hydrochloride

     A tricyclic antidepressant
  42. GC17229 Paroxetine HCl

    盐酸帕罗西汀; BRL29060 hydrochloride; BRL29060A

     A selective serotonin reuptake inhibitor
  43. GC14262 Desvenlafaxine Succinate

    琥珀酸去甲文拉法辛; O-Desmethylvenlafaxine succinate hydrate

     An active metabolite of venlafaxine
  44. GC11570 Desvenlafaxine

    去甲文拉法辛; O-Desmethylvenlafaxine

     An active metabolite of venlafaxine
  45. GC12720 Sertraline HCl

    盐酸舍曲林

     A selective serotonin reuptake inhibitor
  46. GC12055 Milnacipran HCl

    盐酸米那普仑

     A serotonin and norepinephrine reuptake inhibitor
  47. GC14330 Milnacipran

    米那普仑

     A serotonin and norepinephrine reuptake inhibitor
  48. GC13092 Fluvoxamine

    氟伏沙明; DU-23000

     A selective serotonin reuptake inhibitor
  49. GC16797 Escitalopram Oxalate

    依他普仑草酸盐; (S)-Citalopram oxalate; (S)-(+)-Citalopram oxalate

     A selective serotonin reuptake inhibitor
  50. GC13161 Escitalopram

    艾司西酞普兰; (S)-Citalopram; (S)-(+)-Citalopram

     A selective serotonin reuptake inhibitor
  51. GC13871 Duloxetine HCl

    盐酸度洛西汀; (S)-Duloxetine hydrochloride; LY-248686 hydrochloride

     A serotonin and norepinephrine reuptake inhibitor

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