Cell Cycle/Checkpoint(细胞周期/检查点)

Cell Cycle

Cells undergo a complex cycle of growth and division that is referred to as the cell cycle. The cell cycle consists of four phases, G1 (GAP 1), S (synthesis), G2 (GAP 2) and M (mitosis). DNA replication occurs during S phase. When cells stop dividing temporarily or indefinitely, they enter a quiescent state called G0. read more

Products for Cell Cycle/Checkpoint

Cat.No. 产品名称 Information
GC46224 S-Phenylcysteine
S-苯基-L-半胱氨酸
An adduct
GC46219 Satratoxin H A trichothecene mycotoxin
GC46218 Satratoxin G A macrocyclic trichothecene mycotoxin
GC46210 Quinacrine mustard (hydrochloride)
氮芥喹丫因
A fluorescent DNA-intercalating agent
GC46196 Pal-KTTKS (acetate)
C16-KTTKS, Palmitoyl-KTTKS
A lipidated pentapeptide
GC46190 NSC 15520 An inhibitor of RPA70 dsDNA binding
GC46104 Butyric Acid-d7
氘代丁酸(D7),Butanoic acid-d7
An internal standard for the quantification of sodium butyrate
GC39177 Valecobulin hydrochloride
CKD-516 hydrochloride
Valecobulin hydrochloride (CKD-516 hydrochloride) 是 S516 的缬氨酸前体药和血管阻断剂 (VDA), 是一种强效的、β-微管蛋白聚合抑制剂，对小鼠和人类的实体肿瘤具有显著的抗肿瘤活性。
GC39156 AMG PERK 44 AMG PERK 44 是一种口服有效的，高选择性的 PERK 抑制剂，IC50 为 6 nM。AMG PERK 44 对 PERK 的选择性分别是 GCN2 (IC50=7300 nM) 和 B-Raf (IC50 >1000 nM) 的 1000 倍和 160 倍。
GC38945 S516 S516 (Compound 22) 是 CKD-516 的活性代谢产物，是一种有效的微管蛋白聚合抑制剂，其 IC50 值为 4.29 μM。S516 具有显著的抗肿瘤活性。
GC38898 CCG-222740 CCG-222740 is a Rho/MRTF pathway inhibitor. CCG-222740 decreases the activation of stellate cells in vitro and in vivo, by reducing the levels of alpha smooth muscle actin(α-SMA) expression.
GC46019 Pluviatolide
(-)-Pluviatolide
A lignan
GC45969 6β-hydroxy Eplerenone
依普利酮6-BETA-羟基类似物
A major metabolite of eplerenone
GC45958 Myrothecine A A trichothecene mycotoxin
GC45944 para-amino-Blebbistatin
(–)-4'-amino-Blebbistatin, p-amino-Blebbistatin, (S)-4'-amino-Blebbistatin
A more stable and less phototoxic form of (–)-blebbistatin with enhanced water solubility
GC38845 sAJM589 sAJM589 是一种 Myc 抑制剂，能干扰 Myc- max 异二聚体的形成，其 IC50 值为 1.8 μM。
GC38791 GSK-25 GSK-25 是一种有效的、选择性的，具有口服活性的 ROCK1 抑制剂 (IC50=7 nM)。GSK-25 对 31 种激酶以及 RSK1 和 p70S6K 保持良好的选择性 (RSK1: IC50=398 nM, p70S6K: IC50=1 μM)。GSK-25 可抑制 P450 (CYP2C9、CYP2D6、CYP3A4的IC50 分别为2.5、5.2、2.5 μM)。
GC38783 Ginkgolic acid C17:1
银杏酸 C17
A phenolic acid with antibacterial and anticancer activities
GC45903 Quazinone
快嗪酮
A PDE3 inhibitor
GC45890 (+)-Abscisic Acid-d6
(+)-脱落酸-d6; (S)-(+)-Abscisic acid-d6; ABA-d6
An internal standard for the quantification of (+)-abscisic acid
GC45877 CYM 5478 An S1P₂ agonist
GC45846 PKUMDL-LC-101-D04
GPX4-Activator-1d4
An allosteric activator of GPX4
GC45833 N-Oleoyl-L-phenylalanine
18-1-Phe, C18:1-Phe
An N-acyl amide
GC45829 Troglitazone-d4
CS-045-d4
Troglitazone-d4 是氘标记的曲格列酮。 Troglitazone 是一种 PPARγ 激动剂，对人和鼠 PPARγ 受体的 EC50 分别为 550 nM 和 780 nM。
GC45809 AMG-Tie2-1
4-甲基-3-[[3-[2-(甲基氨基)-4-嘧啶基]-2-吡啶基]氧基]-N-[3-(三氟甲基)苯基]苯甲酰胺
A Tie2 and VEGFR2 inhibitor
GC45800 Cytarabine-13C3
Ara-C-13C3, 1-β-D-Arabinofuranosylcytosine-13C3
A neuropeptide with diverse biological activities
GC45798 Rhein-13C4
1,8-二羟基-3-羧基蒽醌

An internal standard for the quantification of rhein
GC45783 1,2-Dioleoyl-rac-glycerol-13C3 An internal standard for the quantification of 1,2-dioleoyl-rac-glycerol
GC45769 Vandetanib-d6
ZD6474-d6
An internal standard for the quantification of vandetanib
GC45764 Ciclopirox-d11 (sodium salt)
HOE 296b-d11
A neuropeptide with diverse biological activities
GC45758 Paclitaxel octadecanedioate
1,18-Octadecanedioic Acid-Paclitaxel, ODDA-PTX, PTX-FA18
A prodrug form of paclitaxel
GC45750 Thymosin β4 (human, mouse, rat, porcine, bovine) (acetate)
Ac-SDKPDMAEIEKFDKSKLKKTETQEKNPLPSKETIEQEKQAGES-NH2
An actin-sequestering peptide
GC45744 monoMICAAc
3-N-methylamino-6-Isocyanoacridine
A solvatochromic fluorescent pH probe
GC45743 ICAAc
3-amino-6-Isocyanoacridine
A solvatochromic fluorophore and pH probe
GC45688 STX140
2-Methoxyestradiol-bis-sulphamate
An estrogen sulfamate
GC45680 Prodan
N,N-二甲基-6-丙酰-2-萘胺
A solvatochromic fluorescent probe
GC45668 Gly-Arg-AMC (hydrochloride)
Gly-Arg-7-amino-4-methylcoumarin, GR-AMC, GR-7-amino-4-methylcoumarin
A fluorogenic substrate for cathepsin C
GC45667 N-(p-Tosyl)-GPR-pNA (acetate)
N-对甲苯磺酰基-甘氨酰-脯氨酰-精氨酰对硝基苯胺
A colorimetric thrombin substrate
GC45639 Hexapeptide-11 (acetate)
FVAPFP, Phe-Val-Ala-Pro-Phe-Pro
A synthetic hexapeptide
GC45616 C6 Urea Ceramide
C6 Ceramide (d18:1/6:0) Urea, Cer(d18:1/6:0) Urea, D-erythro-Urea-C6-Ceramide
An inhibitor of neutral ceramidase
GC38589 MYCi361
NUCC-0196361
MYCi361 is a MYC inhibitor that engages MYC inside cells, disrupts MYC/MAX dimers, and impairs MYC-driven gene expression. MYCi361 binds to MYC with Kd of 3.2 μM. MYCi361 suppresses in vivo tumor growth, increases tumor immune cell infiltration, upregulates PD-L1 on tumors, and sensitizes tumors to anti-PD1 immunotherapy.
GC38588 MYCi975 MYCi975 (NUCC-0200975) is a potent, selective and orally active inhibitor of MYC that disrupts MYC/MAX interaction, promotes MYC T58 phosphorylation and MYC degradation, and impairs MYC driven gene expression. MYCi975 exhibits potent anti-tumor activities.
GC38564 Deoxypodophyllotoxin
脱氧鬼臼毒素
A flavolignan with diverse biological activities
GC38519 Ilorasertib hydrochloride
ABT-348 hydrochloride
A multi-kinase inhibitor
GC38480 Vat-Cit-PAB-Monomethyl Dolastatin 10 Vat-Cit-PAB-Monomethyl Dolastatin 10 是抗体-药物偶联物的一部分，由 Monomethyl Dolastatin 10 (一种有效的微管蛋白抑制剂) 和 ADC linker Vat-Cit-PAB 连接而成。
GC38468 DM4-SMe DM4-SMe 是抗体-美登素偶联物 (AMC) 的代谢产物，是一种微管蛋白 (tubulin) 抑制剂，还是一种抗体-药物偶联物 (ADCs) 的细胞毒性部分，可通过二硫键或稳定的硫醚键与抗体连接。DM4-SMe 抑制 KB 细胞的增殖，IC50 值为 0.026 nM。
GC38460 DM4-SPDP DM4-SPDP 是由连接桥 SPDP 和毒性分子 DM4 连接而成的，可用来制备抗体偶联药物。DM4 是抑制细胞分裂的抗微管蛋剂。SPDP 是一种短链交联剂，可通过 NHS-酯和吡啶基二硫醇反应性基团与半胱氨酸巯基形成可裂解的 (可还原的) 二硫键，实现胺与巯基的结合。
GC38456 Pironetin
NK 10958, NL 9C, PA 48153c, (–)-Pironetin
An inhibitor of microtubule assembly
GC38410 Vincristine
长春新碱,Leurocristine; NSC-67574; 22-Oxovincaleukoblastine
Vincristine是一种通过与微管蛋白结合来抑制微管聚合的抑制剂，在无细胞试验中，其 IC₅₀ 值为 32μM。Vincristine还可诱导细胞凋亡。
GC38403 LDN-192960 hydrochloride An inhibitor of haspin and DYRK2