Cell Cycle/Checkpoint(细胞周期/检查点)

Cell Cycle

Cells undergo a complex cycle of growth and division that is referred to as the cell cycle. The cell cycle consists of four phases, G1 (GAP 1), S (synthesis), G2 (GAP 2) and M (mitosis). DNA replication occurs during S phase. When cells stop dividing temporarily or indefinitely, they enter a quiescent state called G0. read more

Products for Cell Cycle/Checkpoint

Cat.No. 产品名称 Information
GC39486 DCLK1-IN-1 DCLK1-IN-1是DCLK1和DCLK2的高选择性抑制剂，在KINOMEscan结合试验中对DCLK1和DCLK2的IC₅₀分别为9.5nM和31nM。在ATP激酶实验中的IC₅₀分别为57nM和103nM。
GC39483 BO-264 A TACC3 inhibitor
GC50599 P110 Dynamin-related protein 1 (Drp1) inhibitor; cell-permeable
GC50574 MB 0223 Dynamin-related GTPase DRP1 partial inhibitor
GC50529 Surfen
Aminoquincarbamide dihydrochloride
Surfen 是一种有效的 HS（硫酸乙酰肝素）拮抗剂。
GC50439 Peptide5 Peptide5 是一种连接蛋白 43 模拟肽，可减少脊髓损伤后动物肿胀、星形胶质细胞增生和神经元细胞死亡体外:Peptide5 显着降低啮齿动物离体模型中的脊髓损伤 (SCI) 程度。
GC50424 AZ 5704 Potent and selective ATM kinase inhibitor; orally bioavailable
GC50397 Flutax 2 绿色荧光紫杉醇衍生物；结合微管
GC50370 AZ 13705339 AZ 13705339 是一种高效的选择性 PAK1 抑制剂，对 PAK1 和 pPAK1 的 IC50 分别为 0.33 nM 和 59 nM。 AZ 13705339 与 PAK1 和 PAK2 具有结合亲和力，Kds 分别为 0.28 nM 和 0.32 nM。 AZ 13705339 可用于癌症研究。
GC50314 PF 3758309 dihydrochloride
PF-03758309 dihydrochloride
An inhibitor of PAK4
GC50214 LCB 03-0110 dihydrochloride Potent c-SRC kinase inhibitor; also inhibits DDR2, BTK and Syk
GC50175 CGP 74514 dihydrochloride Potent cdk1 inhibitor
GC50145 CHR 6494 trifluoroacetate A selective Haspin protein kinase inhibitor
GC50116 OXA 06 dihydrochloride Potent ROCK inhibitor
GC50110 Mps1-IN-1 dihydrochloride A selective Mps1 kinase inhibitor
GC50092 RKI 1447 dihydrochloride A ROCK1 and ROCK2 inhibitor
GC50056 UA 62784 Inhibits microtubule polymerization
GC50052 Laulimalide
Microtubule stabilzing agent
GC50050 Hesperadin hydrochloride A multi-kinase inhibitor
GC50045 PD 166285 dihydrochloride
6-(2,6-二氯苯基)-2-[[4-[2-(二乙基氨基)乙氧基]苯基]氨基]-8-甲基吡啶并[2,3-D]嘧啶-7(8H)-酮盐酸盐
A tyrosine kinase inhibitor
GC50043 SR 3677 dihydrochloride A ROCK1 and ROCK2 inhibitor
GC50020 Dynamin inhibitory peptide, myristoylated DynaMin inhibitory peptide, myristoylated 是一种 DynaMin 抑制剂，可干扰两性霉素与 dynamin 的结合。
GC39209 LCH-7749944
GNF-PF-2356
LCH-7749944 (GNF-PF-2356) is a novel and potent p21-activated kinase 4 (PAK4) inhibitor with an IC50 of 14.93 μM and has less potently inhibitory effect against PAK1, PAK5 and PAK6. LCH-7749944 causes successful inhibition of EGFR activity due to its inhibitory effect on PAK4.
GC46224 S-Phenylcysteine
S-苯基-L-半胱氨酸
An adduct
GC46219 Satratoxin H A trichothecene mycotoxin
GC46218 Satratoxin G A macrocyclic trichothecene mycotoxin
GC46210 Quinacrine mustard (hydrochloride)
氮芥喹丫因
A fluorescent DNA-intercalating agent
GC46196 Pal-KTTKS (acetate)
C16-KTTKS, Palmitoyl-KTTKS
A lipidated pentapeptide
GC46190 NSC 15520 An inhibitor of RPA70 dsDNA binding
GC46104 Butyric Acid-d7
氘代丁酸(D7),Butanoic acid-d7
An internal standard for the quantification of sodium butyrate
GC39177 Valecobulin hydrochloride
CKD-516 hydrochloride
Valecobulin hydrochloride (CKD-516 hydrochloride) 是 S516 的缬氨酸前体药和血管阻断剂 (VDA), 是一种强效的、β-微管蛋白聚合抑制剂，对小鼠和人类的实体肿瘤具有显著的抗肿瘤活性。
GC39156 AMG PERK 44 AMG PERK 44 是一种口服有效的，高选择性的 PERK 抑制剂，IC50 为 6 nM。AMG PERK 44 对 PERK 的选择性分别是 GCN2 (IC50=7300 nM) 和 B-Raf (IC50 >1000 nM) 的 1000 倍和 160 倍。
GC38945 S516 S516 (Compound 22) 是 CKD-516 的活性代谢产物，是一种有效的微管蛋白聚合抑制剂，其 IC50 值为 4.29 μM。S516 具有显著的抗肿瘤活性。
GC38898 CCG-222740 CCG-222740 is a Rho/MRTF pathway inhibitor. CCG-222740 decreases the activation of stellate cells in vitro and in vivo, by reducing the levels of alpha smooth muscle actin(α-SMA) expression.
GC46019 Pluviatolide
(-)-Pluviatolide
A lignan
GC45969 6β-hydroxy Eplerenone
依普利酮6-BETA-羟基类似物
A major metabolite of eplerenone
GC45958 Myrothecine A A trichothecene mycotoxin
GC45944 para-amino-Blebbistatin
(-)-4'-amino-Blebbistatin, p-amino-Blebbistatin, (S)-4'-amino-Blebbistatin
A more stable and less phototoxic form of (–)-blebbistatin with enhanced water solubility
GC38845 sAJM589 sAJM589 是一种 Myc 抑制剂，能干扰 Myc- max 异二聚体的形成，其 IC50 值为 1.8 μM。
GC38791 GSK-25 GSK-25 是一种有效的、选择性的，具有口服活性的 ROCK1 抑制剂 (IC50=7 nM)。GSK-25 对 31 种激酶以及 RSK1 和 p70S6K 保持良好的选择性 (RSK1: IC50=398 nM, p70S6K: IC50=1 μM)。GSK-25 可抑制 P450 (CYP2C9、CYP2D6、CYP3A4的IC50 分别为2.5、5.2、2.5 μM)。
GC38783 Ginkgolic acid C17:1
银杏酸 C17
A phenolic acid with antibacterial and anticancer activities
GC45903 Quazinone
快嗪酮
A PDE3 inhibitor
GC45890 (+)-Abscisic Acid-d6
(+)-脱落酸-d6; (S)-(+)-Abscisic acid-d6; ABA-d6
An internal standard for the quantification of (+)-abscisic acid
GC45877 CYM 5478 An S1P₂ agonist
GC45846 PKUMDL-LC-101-D04
GPX4-Activator-1d4
An allosteric activator of GPX4
GC45833 N-Oleoyl-L-phenylalanine
18-1-Phe, C18:1-Phe
An N-acyl amide
GC45829 Troglitazone-d4
CS-045-d4
Troglitazone-d4 是氘标记的曲格列酮。 Troglitazone 是一种 PPARγ 激动剂，对人和鼠 PPARγ 受体的 EC50 分别为 550 nM 和 780 nM。
GC45809 AMG-Tie2-1
4-甲基-3-[[3-[2-(甲基氨基)-4-嘧啶基]-2-吡啶基]氧基]-N-[3-(三氟甲基)苯基]苯甲酰胺
A Tie2 and VEGFR2 inhibitor
GC45800 Cytarabine-13C3
Ara-C-13C3, 1-β-D-Arabinofuranosylcytosine-13C3
A neuropeptide with diverse biological activities
GC45798 Rhein-13C4
1,8-二羟基-3-羧基蒽醌

An internal standard for the quantification of rhein