Cell Cycle/Checkpoint(细胞周期/检查点)

Cell Cycle

Cells undergo a complex cycle of growth and division that is referred to as the cell cycle. The cell cycle consists of four phases, G1 (GAP 1), S (synthesis), G2 (GAP 2) and M (mitosis). DNA replication occurs during S phase. When cells stop dividing temporarily or indefinitely, they enter a quiescent state called G0. read more

Products for Cell Cycle/Checkpoint

Cat.No. 产品名称 Information
GC45783 1,2-Dioleoyl-rac-glycerol-13C3 An internal standard for the quantification of 1,2-dioleoyl-rac-glycerol
GC45769 Vandetanib-d6
ZD6474-d6
An internal standard for the quantification of vandetanib
GC45764 Ciclopirox-d11 (sodium salt)
HOE 296b-d11
A neuropeptide with diverse biological activities
GC45758 Paclitaxel octadecanedioate
1,18-Octadecanedioic Acid-Paclitaxel, ODDA-PTX, PTX-FA18
A prodrug form of paclitaxel
GC45750 Thymosin β4 (human, mouse, rat, porcine, bovine) (acetate)
Ac-SDKPDMAEIEKFDKSKLKKTETQEKNPLPSKETIEQEKQAGES-NH2
An actin-sequestering peptide
GC45744 monoMICAAc
3-N-methylamino-6-Isocyanoacridine
A solvatochromic fluorescent pH probe
GC45743 ICAAc
3-amino-6-Isocyanoacridine
A solvatochromic fluorophore and pH probe
GC45688 STX140
2-Methoxyestradiol-bis-sulphamate
An estrogen sulfamate
GC45680 Prodan
N,N-二甲基-6-丙酰-2-萘胺
A solvatochromic fluorescent probe
GC45668 Gly-Arg-AMC (hydrochloride)
Gly-Arg-7-amino-4-methylcoumarin, GR-AMC, GR-7-amino-4-methylcoumarin
A fluorogenic substrate for cathepsin C
GC45667 N-(p-Tosyl)-GPR-pNA (acetate)
N-对甲苯磺酰基-甘氨酰-脯氨酰-精氨酰对硝基苯胺
A colorimetric thrombin substrate
GC45639 Hexapeptide-11 (acetate)
FVAPFP, Phe-Val-Ala-Pro-Phe-Pro
A synthetic hexapeptide
GC45616 C6 Urea Ceramide
C6 Ceramide (d18:1/6:0) Urea, Cer(d18:1/6:0) Urea, D-erythro-Urea-C6-Ceramide
An inhibitor of neutral ceramidase
GC38589 MYCi361
NUCC-0196361
MYCi361 is a MYC inhibitor that engages MYC inside cells, disrupts MYC/MAX dimers, and impairs MYC-driven gene expression. MYCi361 binds to MYC with Kd of 3.2 μM. MYCi361 suppresses in vivo tumor growth, increases tumor immune cell infiltration, upregulates PD-L1 on tumors, and sensitizes tumors to anti-PD1 immunotherapy.
GC38588 MYCi975 MYCi975 (NUCC-0200975) is a potent, selective and orally active inhibitor of MYC that disrupts MYC/MAX interaction, promotes MYC T58 phosphorylation and MYC degradation, and impairs MYC driven gene expression. MYCi975 exhibits potent anti-tumor activities.
GC38564 Deoxypodophyllotoxin
脱氧鬼臼毒素
A flavolignan with diverse biological activities
GC38519 Ilorasertib hydrochloride
ABT-348 hydrochloride
A multi-kinase inhibitor
GC38480 Vat-Cit-PAB-Monomethyl Dolastatin 10 Vat-Cit-PAB-Monomethyl Dolastatin 10 是抗体-药物偶联物的一部分，由 Monomethyl Dolastatin 10 (一种有效的微管蛋白抑制剂) 和 ADC linker Vat-Cit-PAB 连接而成。
GC38468 DM4-SMe DM4-SMe 是抗体-美登素偶联物 (AMC) 的代谢产物，是一种微管蛋白 (tubulin) 抑制剂，还是一种抗体-药物偶联物 (ADCs) 的细胞毒性部分，可通过二硫键或稳定的硫醚键与抗体连接。DM4-SMe 抑制 KB 细胞的增殖，IC50 值为 0.026 nM。
GC38460 DM4-SPDP DM4-SPDP 是由连接桥 SPDP 和毒性分子 DM4 连接而成的，可用来制备抗体偶联药物。DM4 是抑制细胞分裂的抗微管蛋剂。SPDP 是一种短链交联剂，可通过 NHS-酯和吡啶基二硫醇反应性基团与半胱氨酸巯基形成可裂解的 (可还原的) 二硫键，实现胺与巯基的结合。
GC38456 Pironetin
NK 10958, NL 9C, PA 48153c, (-)-Pironetin
An inhibitor of microtubule assembly
GC38410 Vincristine
长春新碱,Leurocristine; NSC-67574; 22-Oxovincaleukoblastine
Vincristine是一种通过与微管蛋白结合来抑制微管聚合的抑制剂，在无细胞试验中，其 IC₅₀ 值为 32μM。Vincristine还可诱导细胞凋亡。
GC38397 MMAF sodium
Monomethylauristatin F sodium
An auristatin with anticancer activity
GC38355 DM3-SMe DM3-SMe 是一种美登素衍生物，是一种微管蛋白 (tubulin) 抑制剂，是一种抗体-药物偶联物 (ADCs) 的细胞毒性部分，可通过二硫键或稳定的硫醚键与抗体连接。DM3-SMe 在体外显示出高度的细胞毒性活性，IC50 为 0.0011 nM。
GA23742 Z-D-Arg-Gly-Arg-pNA . 2 HCl
Z-D-ARG-GLY-ARG-PNA二盐酸盐
A colorimetric Factor Xa substrate
GA23633 T-Peptide T-peptide 是一种 Tuftsin 类似物，可用于人类免疫缺陷病毒 (HIV) 感染的研究。
GA23337 Oxythiamine . HCl
羟基硫胺盐酸盐
A thiamine antimetabolite
GA22303 H-D-Pro-Phe-Arg-pNA . 2 HCl
pFR-pNA, Plasma Kallikrein Chromogenic Substrate, D-Pro-Phe-Arg-p-nitroaniline
A colorimetric plasma kallikrein substrate
GA21951 H-4-Nitro-Phe-OEt . HCl
3-(4-硝基苯基)-L-丙氨酸盐酸盐
A building block
GA21397 Dolastatin 15
DLS 15
A peptide with anticancer activity
GA20494 Ac-Asp-Glu-Val-Asp-pNA
Ac-Asp-Glu-Val-Asp-pNA
A colorimetric caspase substrate
GC45599 Z-Phe-Tyr(tBu)-diazomethylketone
Cbz-Phe-Tyr(O-t-Bu)-CHN2, Z-Phe-Tyr(tBu)-CHN2
An inhibitor of cathepsin L
GC45595 Vulpinic Acid
吴耳酸
A lichen metabolite with diverse biological activities
GC45572 Suc-YVAD-pNA
Caspase-1 and Caspase-4 Chromogenic Substrate, Suc-Tyr-Val-Ala-Asp-p-nitroanilide
A colorimetric caspase-1 and -4 substrate
GC45562 scyllo-Inositol hexakisphosphate (sodium salt)
scylloIP6
A stereoisomer of IP₆
GC45552 Pyrenophorol A fungal metabolite with diverse biological activities
GC45541 PAR3 (1-6) amide (human) (trifluoroacetate salt)
Proteinase-Activated Receptor 3, TFRGAP-NH2
A peptide agonist of PAR1 and PAR2
GC45538 Oxychlororaphine
吩嗪-1-甲酰胺,phenazine-1-carboxamide
A microbial metabolite with diverse biological activities
GC45534 OH-Chol A cationic cholesterol derivative
GC45531 N-α-Benzoyl-L-Arginine ethyl ester (hydrochloride)
BAEE, Bz-Arg-OEt, NSC 86159
A nonpeptide substrate of proteases and deiminases
GC45523 Nemorosone A PPAP with antiproliferative properties
GC45515 MX1013
CV1013; Z-VD-FMK
A dipeptide pan-caspase inhibitor
GC45479 Histone H3K36Me3 (31-41) (trifluoroacetate salt)
Histone H3 (31-41) (Lys36me3), Lys(Me3)36-Histone H3 (31-41), STGGV-K(Me3)-KPHRY
A peptide fragment of histone H3
GC45471 H-Gly-Arg-pNA (hydrochloride)
Gly-Arg-4-NA, GR-pNA, GR p-nitroanilide
A colorimetric thrombin substrate
GC45419 D-chiro-Inositol 1,2,3,4,5,6-hexakisphosphate (sodium salt) A stereoisomer of IP₆
GC45414 CRT0066854 A PKCι and PKCζ inhibitor
GC45405 CAY10737 A turn-on fluorescent probe for carbon monoxide
GC45395 Cabazitaxel-d9
XRP6258-d9; RPR-116258A-d9; taxoid XRP6258-d9
An internal standard for the quantification of cabazitaxel
GC45394 Bz-IEGR-pNA (acetate)
Bz-Ile-Glu-Gly-Arg-pNA, Bz-Ile-Glu-Gly-Arg-p-nitroanilide, Factor Xa Chromogenic Substrate
A colorimetric Factor Xa substrate
GC45385 Ara-G
9-Β-D-糖呋喃鸟嘌呤
An anticancer nucleoside analog