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Home >> Signaling Pathways >> Cell Cycle/Checkpoint

Cell Cycle/Checkpoint(细胞周期/检查点)

Cell Cycle

Cells undergo a complex cycle of growth and division that is referred to as the cell cycle. The cell cycle consists of four phases, G1 (GAP 1), S (synthesis), G2 (GAP 2) and M (mitosis). DNA replication occurs during S phase. When cells stop dividing temporarily or indefinitely, they enter a quiescent state called G0. read more

Products for  Cell Cycle/Checkpoint

  1. Cat.No. 产品名称 Information
  2. GC35651 Cenisertib

    AS-703569; R-763

     Cenisertib (AS-703569) 是一种多激酶抑制剂，可抑制 Aurora-kinase-A/B，ABL1，AKT，STAT5, FLT3 的活性。 Cenisertib 通过抑制肿瘤肥大细胞 (MC) 中几种不同分子靶标的活性抑制其生长。 Cenisertib 抑制异种移植模型中胰腺癌，乳腺癌，结肠癌，卵巢癌和肺癌以及白血病的肿瘤生长。
  3. GC35442 Azaindole 1

    6-氯-N4-[3,5-二氟-4-[(3-甲基-1H-吡咯并[2,3-B]吡啶-4-基)氧]苯基]-2,4-嘧啶二胺,ROCK-IN-2?，TC-S 7001

     A ROCK1 and ROCK2 inhibitor
  4. GC35430 Auristatin F

    澳瑞他汀 F

    Auristatin F是细胞毒性分子，微管蛋白修饰分子，强效抗肿瘤活性，MMAF的类似物以及在抗体药物偶连体开发中作为毒素分子。
  5. GC35429 Auristatin E

    澳瑞他汀 E；奥利斯他汀 E

     Auristatin E是细胞毒性分子，微管蛋白修饰分子，强效抗肿瘤活性，MMAE的类似物以及在抗体药物偶连体开发中作为毒素分子。
  6. GC35262 Afzelin

    阿福豆苷,Kaempferol-3-O-rhamnoside

     A polyphenolic glycoside flavone with diverse biological activities
  7. GC35216 AAPK-25 AAPK-25 是一种有效选择性的 Aurora/PLK 激酶双重抑制剂，具有抗肿瘤活性。AAPK-25 可引起有丝分裂延迟并阻滞前中期细胞，通过生物标志物组蛋白 H3Ser10 磷酸化反应，随后细胞凋亡激增。AAPK-25 靶向 Aurora-A, -B, -C 的 Kd 值为 23 nM-289 nM，靶向 PLK-1, -2, -3 的 Kd 值为 55-456 nM。
  8. GC35197 7-xylosyltaxol

    7-木糖基紫杉醇,7-Xylosylpaclitaxel; Taxol-7-xyloside

     A taxane with microtubule disruptor and anticancer activities
  9. GC35189 7-Epi-docetaxel

    7-表多西他赛,4-epi-Docetaxel; 7-Epidocetaxel; 7-Epitaxotere

     7-Epi-10-oxo-docetaxel (Docetaxel Impurity C; 7-Epitaxotere)是多西他赛（docetaxel）的杂质。
  10. GC35188 7-Epi-10-oxo-docetaxel

    7-表-10-氧多西他塞,Docetaxel Impurity 2

     7-Epi-10-oxo-docetaxel (Docetaxel Impurity 2) 是多西他赛（docetaxel）的杂质。
  11. GC35045 10-Oxo Docetaxel

    10-羰基多西他赛,Docetaxel Impurity 1

     A docetaxel degradation product
  12. GC35044 10-Deacetyl-7-xylosyl paclitaxel

    7-木糖甙-10-脱乙酰基紫杉醇,10-Deacetyl-7-xylosyltaxol; 10-Deacetylpaclitaxel 7-Xyloside; 10-Deacetyltaxol 7-Xyloside

     A microtubule disruptor
  13. GC34999 (S)-Ceralasertib

    (S)-AZD6738

     (S)-Ceralasertib 从专利 WO2011154737A1 中获取，化合物 II，IC50 为 2.578 nM。(S)-Ceralasertib 是一种有效的选择性亚砜亚胺吗啉代嘧啶 ATR 抑制剂，具有优异的临床前物化和药代动力学 (PK) 特征。(S)-Ceralasertib 水溶性改善，并且消除 CYP3A4 时间依赖性抑制。
  14. GC45226 β-BHC

    β-HCH, β-Hexachlorocyclohexane, β-Lindane

     β-BHC is an isomer of the organochlorine pesticide γ-lindane that is a potential impurity found in commercial preparations of lindane.
  15. GC45193 Z-YVAD-CMK (trifluoroacetate salt)

    Benxyloxycarbonyl-Tyr-Val-Ala-Asp-Chloromethylketone, Caspase-1 Inhibitor IV

     An inhibitor of caspase-1 and caspase-3
  16. GC45191 Z-VDVAD-pNA (trifluoroacetate salt)

    Z-VDVAD-p-nitroanilide, Z-Val-Asp-Val-Ala-Asp-pNA, Z-Val-Asp-Val-Ala-Asp-p-nitroanilide

     A colorimetric caspase-2 substrate
  17. GC45190 Z-VDVAD-AFC (trifluoroacetate salt)

    Z-Val-Asp-Val-Ala-Asp-AFC, Z-Val-Asp-Val-Ala-Asp-7-amino-4-trifluormethylcoumarin

     A fluorogenic substrate for caspase-2
  18. GC45181 Z-IETD-AFC

    Z-异亮氨酰-谷氨酰-苏氨酰-天冬氨酸-AFC

     A fluorogenic substrate for caspase-8 and granzyme B
  19. GC45178 Z-DEVD-CMK (trifluoroacetate salt)

    Z-Asp-Glu-Val-Asp-CMK

    An irreversible protease inhibitor
  20. GC45177 Z-AEVD-FMK

    Z-Ala-Glu-Val-Asp-Fluoromethyl Ketone

     A caspase-10 inhibitor
  21. GC45175 YVAD-CHO (trifluoroacetate salt)

    H-Tyr-Val-Ala-Asp-CHO

     A caspase-1/ICE inhibitor
  22. GC45149 VK3-OCH3

    Vitamin K3-OCH3

     An analog of vitamin K3
  23. GC45089 Trinactin

    三活菌素

     A non-selective monovalent cation ionophore
  24. GC45086 Trigalacturonic Acid

    半乳糖醛酸

     三半乳糖醛酸是一种低聚糖，可抑制番茄植物中的蛋白酶活性（ED50 \u003d 2.6 μg/植物）。
  25. GC45066 Tosyl Phenylalanyl Chloromethyl Ketone

    L-1,4'-甲基磺酰基-2-苯基乙基氯甲基酮,L-1-Tosylamido-2-phenylethyl chloromethyl ketone; L-TPCK

     An inhibitor of chymotrypsin-like serine proteases
  26. GC45039 Thiocolchicine

    硫代秋水仙碱

     An inhibitor of microtubule assembly
  27. GC45022 Tetranactin

    杀螨素

     A monovalent cation ionophore
  28. GC45015 Termitomycamide E

    2'Deoxotermitomycamide A

     A fatty acid amide that protects against ER stress-dependent cell death
  29. GC45014 Termitomycamide B A fatty acid amide that protects against ER stress-dependent cell death
  30. GC45013 Tenuazonic Acid (copper salt)

    AAC-toxin

     A common mycotoxin food contaminant
  31. GC44983 T2AA (hydrochloride)

    T2-amino Alcohol

     An inhibitor of PCNA
  32. GC44976 Swinholide A An actin depolymerizing macrolide
  33. GC44967 Suc-YVAD-AMC (acetate)

    Suc-Tyr-Val-Ala-Asp-AMC, Suc-Tyr-Val-Ala-Asp-7-amino-4-methylcoumarin, Suc-YVAD-NH-Mec

     A fluorogenic substrate for caspase-1
  34. GC44963 Suc-Leu-Tyr-AMC

    N-琥珀酰基-亮氨酰-酪氨酸-7-胺基-4-甲基香豆素

     Suc-Leu-Tyr-AMC是一种测量20S蛋白酶体凝乳胰蛋白酶样肽酶活性的calpain I和II和papain（半胱氨酸蛋白酶）荧光底物，发出明亮的荧光，已广泛用于calpain I和II和pap蛋白酶的评价（激发/发射光：360/460nm）。
  35. GC44947 SRS16-86 A ferroptosis inhibitor
  36. GC44946 Sporidesmolide III A cyclodepsipeptide
  37. GC44847 RKI-1313 A ROCK1 and ROCK2 inhibitor
  38. GC44846 RK-682 (calcium salt)

    CI-010, TAN 1364B

     An inhibitor of PTPs
  39. GC44829 Rhod-5N (potassium salt) A low affinity fluorescent calcium probe
  40. GC44800 Quininib A CysLT1 and CysLT2 receptor antagonist
  41. GC44771 PtdIns-(5)-P1 (1,2-dipalmitoyl) (ammonium salt)

    DPPI5P1

     A membrane phospholipid important for cellular signaling
  42. GC44770 PtdIns-(5)-P1 (1,2-dioctanoyl) (ammonium salt)

    DOPI5P1, Phosphatidylinositol5phosphate C8

     A synthetic phosphatidylinositol for signal transduction research
  43. GC44767 PtdIns-(4,5)-P2-biotin (sodium salt)

    Phosphatidylinositol4,5diphosphate C8biotin

     An affinity probe for PI3-kinases and PIP-binding proteins
  44. GC44766 PtdIns-(4,5)-P2 (1,2-dipamitoyl)-d62 (sodium salt)

    DPPI4,5P2d62, Phosphatidylinositol4,5diphosphate C16d62

     An internal standard for the quantification of PtdIns-(4,5)-P2 (1,2-dipamitoyl) (sodium salt)
  45. GC44765 PtdIns-(4,5)-P2 (1,2-dipalmitoyl) (sodium salt)

    DPPI4,5P2, Phosphatidylinositol4,5diphosphate C16

     A synthetic phosphatidylinositol for signal transduction research
  46. GC44764 PtdIns-(4,5)-P2 (1,2-dipalmitoyl) (ammonium salt)

    DPPI4,5P2, Phosphatidylinositol4,5diphosphate C16

     A membrane phospholipid
  47. GC44763 PtdIns-(4,5)-P2 (1,2-dioctanoyl) (sodium salt)

    DOPI4,5P2, Phosphatidylinositol4,5bisphosphate C8

     A phosphatidylinositol
  48. GC44762 PtdIns-(4,5)-P2 (1,2-dihexanoyl) (sodium salt)

    DHPI4,5P2, Phosphatidylinositol4,5bisphosphate C6

     A synthetic phosphatidylinositol for signal transduction research
  49. GC44761 PtdIns-(4)-P1 (1,2-dipalmitoyl) (ammonium salt)

    DPPI4P1

     A phospholipid with roles in cell signaling
  50. GC44759 PtdIns-(4)-P1 (1,2-dioctanoyl) (ammonium salt)

    DOPI4P1, Phosphatidylinositol4phosphate C8

     A synthetic phosphatidylinositol for signal transduction research
  51. GC44758 PtdIns-(4)-P1 (1,2-dihexanoyl) (sodium salt)

    DHPI4P1, Phosphatidylinositol4phosphate C6

     A synthetic phosphatidylinositol for signal transduction research

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