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Home >> Signaling Pathways >> Cell Cycle/Checkpoint

Cell Cycle/Checkpoint(细胞周期/检查点)

Cell Cycle

Cells undergo a complex cycle of growth and division that is referred to as the cell cycle. The cell cycle consists of four phases, G1 (GAP 1), S (synthesis), G2 (GAP 2) and M (mitosis). DNA replication occurs during S phase. When cells stop dividing temporarily or indefinitely, they enter a quiescent state called G0. read more

Products for  Cell Cycle/Checkpoint

  1. Cat.No. 产品名称 Information
  2. GC68588 AA-T3A-C12 AA-T3A-C12 是一种茴香酰胺配体-栓系类脂质 (AA-lipidoid)。AA-T3A-C12 介导大量 RNA 递送和活化的成纤维细胞的转染。
  3. GC25940 SNS-314 SNS-314 is a potent and selective inhibitor of Aurora A, Aurora B and Aurora C with IC50 of 9 nM, 31 nM, and 3 nM, respectively. It is less potent to Trk A/B, Flt4, Fms, Axl, c-Raf and DDR2. Phase 1.
  4. GC25482 GSK269962A HCl

    GSK269962B, GSK269962, GSK 269962

     GSK269962A HCl (GSK269962B, GSK269962) is a selective ROCK(Rho-associated protein kinase) inhibitor with IC50 values of 1.6 and 4 nM for ROCK1 and ROCK2, respectively.
  5. GC25372 Elimusertib (BAY-1895344) hydrochloride

    BAY-1895344 HCl

     Elimusertib (BAY-1895344) hydrochloride is a potent, highly selective and orally available ATR inhibitor with an IC50 of 7 nM.
  6. GC25075 Ansamitocin p-3 (Maytansinol isobutyrate, NSC292222)

    Antibiotic C 15003P3

     Ansamitocin p-3 (Maytansinol isobutyrate, NSC292222, Antibiotic C 15003P3) is a potent inhibitor of tubulin polymerization with IC50 of 3.4 μM.
  7. GC25025 Abraxane

    Nab-Paclitaxel

     Abraxane (Nab-Paclitaxel), a novel solvent-free taxane with the binding ratio of Paclitaxel to human serum albumin of 1:9, is an anti-microtubule drug that promotes microtubule aggregation in tubulin dimer and inhibits microtubule depolymerization to stabilize the microtubule system.
  8. GC68416 RAD51-IN-3 RAD51-IN-3 是一种 RAD51 抑制剂，详细信息请参考专利 WO2019051465A1 的化合物 Example 66A。
  9. GC68366 Thiocolchicine-d3 Thiocolchicine-d3 是 Thiocolchicine 氘代物。Thiocolchicine 是秋水仙碱 的衍生物，是一种有效的微管蛋白聚合 (tubulin polymerization) 抑制剂 (IC50=2.5 µM)，竞争性结合微管蛋白 (Ki=0.7 µM)。Thiocolchicine 可以作为 ADC 的毒素分子。
  10. GC68309 tri-GalNAc-COOH tri-GalNAc-COOH 是一种去唾液酸糖蛋白受体 (ASGPR) 配体，可用于溶酶体靶向嵌合体 (LYTAC) 研究。
  11. GC68147 dAURK-4 hydrochloride dAURK-4 hydrochloride 是 Alisertib 的一种衍生物，是一种有效的选择性 AURKA (Aurora A) 降解剂。dAURK-4 hydrochloride 具有抗癌作用。
  12. GC68024 Antiproliferative agent-14 Antiproliferative agent-14 (compound 3b) 是一种有效的微管蛋白聚合 (tubulin polymerization) 抑制剂，IC50 为 3.41 μM。Antiproliferative agent-14 具有优异的抗增殖活性。Antiproliferative agent-14 具有在细胞周期的 G2/M 期阻滞细胞的能力。
  13. GC68021 BMVC BMVC 是一种有效的 G-四联体 (G4) 稳定剂和选择性的端粒酶 (Telomerase) 抑制剂，IC50 约为 0.2 μM。BMVC 抑制 Taq DNA 聚合酶，IC50 约为 2.5 μ M。BMVC 提高了端粒 G4 结构的熔化温度，并加速了端粒长度的缩短。抗癌活性。
  14. GC67900 AMXI-5001 hydrochloride AMXI-5001 hydrochloride 是一种有效的、具有口服活性的 parp1/2 和微管聚合抑制剂。MXI-5001 hydrochloride 对多种人类癌细胞表现出选择性抗肿瘤细胞毒性，其 IC50s 比现有的临床 PARP1/2 抑制剂低得多。AMXI-5001 hydrochloride 诱导已建立的肿瘤完全消退，包括非常大的肿瘤。
  15. GC67899 Aurora kinase inhibitor-8 Aurora kinase inhibitor-8 是一种高选择性 Aurora 激酶的抑制剂。
  16. GC67888 RAD51-IN-5 RAD51-IN-5 是一种有效的 RAD51 抑制剂。RAD51 是一种真核生物基因。RAD51-IN-5 具有研究线粒体缺陷病症的潜力 (摘自专利 WO2021164746A1，化合物 3)。
  17. GC52513 Indolimine-214

    Isoamylindolimine

     A genotoxic gut microbiota metabolite
  18. GC52499 Abz-Ala-Pro-Glu-Glu-Ile-Met-Arg-Arg-Gln-EDDnp (trifluoroacetate salt) A sensitive substrate for neutrophil elastase
  19. GC52489 Ceramide (hydroxy) (bovine spinal cord) A sphingolipid
  20. GC52486 Ceramide Phosphoethanolamine (bovine)

    N-Acyl Ceramide Phosphoethanolamine (d18:1/acyl mixture), CPE, N-acyl-D-erythro-Sphingosylphosphorylethanolamine

     A sphingolipid
  21. GC52485 Ceramide (non-hydroxy) (bovine spinal cord) A sphingolipid
  22. GC52484 Purified Ganglioside Mixture (bovine) (ammonium salt) A mixture of purified bovine gangliosides
  23. GC52474 Arg-Gly-Asp (trifluoroacetate salt)

    RGD

     A synthetic peptide corresponding to an integrin cell adhesion sequence
  24. GC52472 Inostamycin A (sodium salt)

    Inostamycin

     A bacterial metabolite with anticancer activity
  25. GC52447 Suc-Leu-Leu-Val-Tyr-AMC (trifluoroacetate salt)

    Suc-LLVY-AMC

     A fluorogenic substrate for the 20S proteasome and calpains
  26. GC52389 Caveolin-1 (82-101) amide (human, mouse, rat, porcine, bovine, ovine) (trifluoroacetate salt)

    Cav-1, Caveolin-1 Scaffolding Domain Peptide, CSD, CSP, DGIWKASFTTFTVTKYWFYR-NH2

     A synthetic peptide fragment of caveolin-1
  27. GC52372 Ac-VDVAD-AFC (trifluoroacetate salt)

    N-Acetyl-Val-Asp-Val-Ala-Asp-AFC, N-Acetyl-Val-Asp-Val-Ala-Asp-7-amino-4-Trifluoromethylcoumarin, Caspase-2 Substrate (Fluorogenic)

     A fluorogenic substrate for caspase-2
  28. GC52371 Vimentin (G146R) (139-159)-biotin Peptide

    Biotin-GQGKSRLRDLYEEEMRELRRQ, Biotin-GQGKSRLRDLYEEEMRELRRQ (X=Citrulline), VIM (G146R) (139-159)-biotin

     A biotinylated mutant vimentin peptide
  29. GC52370 Citrullinated Vimentin (R144) (139-159)-biotin Peptide

    Biotin-GQGKS(Cit)LGDLYEEEMRELRRQ, Biotin-GQGKSXLGDLYEEEMRELRRQ (X=Citrulline), Citrullinated VIM (R144)-biotin

     A biotinylated and citrullinated vimentin peptide
  30. GC52367 Citrullinated Vimentin (G146R) (R144 + R146) (139-159)-biotin Peptide

    Biotin-GQGKS(Cit)L(Cit)DLYEEEMRELRRQ, Biotin-GQGKSXLXDLYEEEMRELRRQ (X=Citrulline), Citrullinated VIM (G146R) (R144 + R146)-biotin

     A biotinylated and citrullinated mutant vimentin peptide
  31. GC52365 4-tert-Octylphenol monoethoxylate

    NSC 5259, OP1EO

     An alkylphenolethoxylate and a degradation product of non-ionic surfactants
  32. GC52364 Vimentin (139-159)-biotin Peptide

    VIM (139-159)-biotin

     A biotinylated vimentin peptide
  33. GC52360 Chymotrypsin Substrate I, Colorimetric (trifluoroacetate salt)

    Suc-GGF-pNA, Suc-Gly-Gly-Phe-pNA, Suc-Gly-Gly-Phe-p-Nitroanilide

     A colorimetric chymotrypsin substrate
  34. GC52358 Malachite Green (chloride)

    Basic Green 4, C.I. 4200, C.I. 42000

     A triphenylmethane dye
  35. GC52332 Arimoclomol

    BRX-220

     A co-inducer of heat shock proteins
  36. GC52293 STAT3 Inhibitor 4m

    Signal Transducer and Activator of Transcription 3 Inhibitor 4m

     A STAT3 inhibitor
  37. GC52288 Fumonisin B1-13C34

    FB1-13C34

     An internal standard for the quantification of fumonisin B1
  38. GC52245 CAY10792 An anticancer agent
  39. GC52227 5-(3',4'-Dihydroxyphenyl)-γ-Valerolactone

    (±)-δ-(3,4-Dihydroxyphenyl)-γ-Valerolactone, 5-(3',4'-Dihydroxyphenyl)-γ-VL

     An active metabolite of various polyphenols
  40. GC67333 Estramustine Estramustine 是一种抗肿瘤剂。Estramustine 通过与微管蛋白 1 (tubulin 1)结合来解聚微管，具有抗有丝分裂活性，对 DU 145 细胞有丝分裂的 IC50 大约为 16 μM。Estramustine 在前列腺肿瘤异种移植模型中阻断前列腺肿瘤细胞有丝分裂。
  41. GC66457 MY-875 MY-875 是一种竞争性的微管蛋白聚合 (microtubulin polymerization) 抑制剂, IC50 值为 0.92 μM。MY-875 通过靶向秋水仙碱结合位点抑制微管蛋白聚合，同时可以激活 Hippo 通路。MY-875 可以诱导细胞凋亡 (apoptosis)，具有抗癌活性。
  42. GC66437 SB-216 SB-216 是一种有效的微管蛋白聚合 (tubulin polymerization) 抑制剂。SB-216 在包括黑色素瘤、肺癌和乳腺癌在内的一系列人类癌症细胞株中显示出很强的抗增殖能力。SB-216 可用于癌症研究。
  43. GC66338 ROCK1-IN-1 WAY-624704 is a novel Rho kinases (ROCK) inhibitor with an Ki of 17 nM.
  44. GC66242 Flutax-2 (5/6-mixture) Flutax-2 (5/6-mixture) 是紫杉醇的活性荧光衍生物。Flutax-2 (5/6-mixture) 与聚合的 α,β 微管蛋白二聚体结合。Flutax-2 (5/6-mixture) 能够稳定 T. gallinae 和 T. foetus 滋养体的微管。
  45. GC66198 Anti-α-Tubulin Antibody, AF555 conjugate Anti-α-Tubulin Antibody, AF555 conjugate 是小鼠抗 α-tubulin 单抗和红色荧光染料 Alexa Fluor 555 的偶联物，可用于检测微管蛋白 (Ex/Em: 554/567 nm)。
  46. GC66056 Dynole 2-24 Dynole 2-24 是一种基于吲哚的 dynamin GTPase 抑制剂 (对 dynamin I的IC50=0.56 μM)。Dynole 2-24 无毒，在体外和细胞内显示出增强的抗动力蛋白I和II的效力 (IC??(CME)=1.9 μM)。Dynole 2-24 对 dynamin I的选择性为4.4倍。Dynole 2-24在网格蛋白介导的内吞作用的细胞抑制剂中具有活性。CME: Clathrin mediated endocytosis
  47. GC66050 Rho-Kinase-IN-2 Rho-Kinase-IN-2 (Compound 23) 是一种具有口服活性的、选择性的和中枢神经系统 (CNS) 渗透性的 Rho激酶 (ROCK) 抑制剂 (ROCK2 IC50=3 nM)。Rho-Kinase-IN-2 可用于亨廷顿病的研究。
  48. GC66036 AZ13705339 hemihydrate AZ13705339 hemihydrate 是一种高效且具有选择性的 PAK1 抑制剂，对 PAK1 和 pPAK1 的 IC50 分别为 0.33 nM 和 59 nM。AZ13705339 hemihydrate 对 PAK1 和 PAK2 具有结合亲和力，Kd 分别为 0.28 nM 和 0.32 nM。AZ13705339 hemihydrate 可用于癌症研究。
  49. GC65994 WEE1-IN-5 Debio 0123 is an inhibitor of Wee1 kinase which is a key regulator of the G2/M and S phase checkpoints.
  50. GC65935 CAM833 CAM833是一种亚微摩尔化学抑制剂，可抑制肿瘤抑制因子BRCA2的RAD51重组酶和BRC重复基序之间的调节蛋白相互作用。
  51. GC65930 Vitamin K3-d8

    维生素K3-d8

     Vitamin K3-d8 是 Vitamin K3 的氘代物。

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